|
T22089 |
HPI 1
|
|
Hedgehog/Smoothened
|
|
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... |
|
T24159 |
IHR-1
|
IHR 1 |
Smo
|
|
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. |
|
T15370 |
GANT 58
|
NSC 75503 |
Hedgehog/Smoothened
|
|
GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM). |
|
T3070 |
GANT 61
|
NSC 136476,GANT61 |
Hedgehog/Smoothened
,
Autophagy
|
|
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2. |
|
T17044 |
Tesaglitazar
|
|
PPAR
|
|
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0... |
|
T27841 |
Lobeglitazone Sulfate
|
CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD
|
|
Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... |
|
T68053 |
Denagliptin
|
GW823093 |
DPP-4
|
|
Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of type 2 diabetes. |
|
T0127 |
Glimepiride
|
Glimperide,HOE-490 |
Potassium Channel
|
|
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
|
T1782 |
Canagliflozin
|
JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 |
SGLT
|
|
Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes. |
|
T4999 |
Ertugliflozin
|
MK-8835,PF-04971729 |
SGLT
|
|
PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). |
|
T28757 |
Sergliflozin etabonate
|
GW-869682,GW-869682X,KGT-1251,GW869682X,GW869682,KGT1251 |
SGLT
|
|
Sergliflozin etabonate (KGT-1251) is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity. |
|
T3547 |
Sotagliflozin
|
LX-4211,LP-802034 |
SGLT
|
|
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. |
|
T1782L |
Canagliflozin hemihydrate
|
JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 |
SGLT
|
|
Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab... |
|
T16083 |
Mizagliflozin
|
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT
|
|
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... |
|
T38843 |
Enavogliflozin
|
DWP-16001 |
SGLT
|
|
Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor. |
|
T3170 |
Troglitazone
|
CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay |
Apoptosis
,
Ferroptosis
,
PPAR
,
Autophagy
|
|
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity. |
|
T1603 |
Glipizide
|
CP 28720,K 4024 |
Potassium Channel
,
PPAR
,
ABC
|
|
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
|
T1634 |
Glibenclamide
|
Glyburide |
Potassium Channel
,
Mitochondrial Metabolism
,
CFTR
,
P-gp
,
Autophagy
|
|
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
|
T28501 |
Ragaglitazar
|
NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 |
PPAR
|
|
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglitazar can be used to study type 2 diabetes. |
|
T5903 |
Sitagliptin Intermediate 2
|
|
|
|
Sitagliptin Intermediate 2 is a useful organic compound that has been used in life science related research. |
|
T64332 |
Glimepiride sulfonamide
|
|
Immunology/Inflammation related
|
|
Glimepiride sulfonamide is an antiinflammatory agent. |
|
T0371 |
Gliquidone
|
AR-DF 26,Glurenorm |
Potassium Channel
|
|
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared... |
|
T1527 |
Gliclazide
|
S1702,SE1702 |
Potassium Channel
|
|
Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin. |
|
T2296 |
Trelagliptin succinate
|
SYR-472 succinate,SYR472 |
Proteasome
,
DPP-4
|
|
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D). |
|
T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
|
BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate |
SGLT
|
|
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre... |
|
T2389 |
Dapagliflozin
|
BMS-512148 |
SGLT
,
HIF
|
|
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. |
|
T0191 |
Linagliptin
|
BI 1356 |
Ferroptosis
,
Proteasome
,
DPP-4
,
Autophagy
|
|
Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. |
|
T2351 |
Fasiglifam
|
TAK875 |
GPR
|
|
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist. |
|
T15385 |
Glibornuride
|
|
Potassium Channel
|
|
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent. |
|
T8493 |
Ingliforib
|
GPi 296,CP 368296 |
Phosphorylase
|
|
Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties. |
|
T12710 |
Retagliptin Phosphate
|
SP 2086 |
Proteasome
,
DPP-4
|
|
Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes. |
|
T4639 |
Azemiglitazone
|
MSDC 0602 |
Mitochondrial Metabolism
,
mTOR
|
|
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes. |
|
T21587 |
Muraglitazar
|
Pargluva,BMS-298585 |
PPAR
|
|
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r... |
|
T3104 |
Globalagliatin
|
LY2608204 |
Glucokinase
|
|
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2. |
|
T26986 |
Cevoglitazar
|
LBM-642,LBM 642,LBM642 |
PPAR
|
|
Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys. |
|
T27303 |
Farglitazar
|
GI-262570,GI-2570,GW 262570X,GI 262570,GI262570 |
PPAR
|
|
Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer that inhibits stellate cell activation by activating receptor γ via oxidative enzymes proliferators and is used in the study of diabetes. |
|
T8239 |
Cromoglicic acid
|
|
Others
|
|
Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. |
|
T0334 |
Rosiglitazone
|
BRL49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. |
|
T0214L |
Pioglitazone hydrochloride
|
U-72107E,AD 4833,U 72107A,Pioglitazone HCl |
Ferroptosis
,
PPAR
|
|
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
|
T0178 |
Saxagliptin hydrate
|
Onglyza hydrate,BMS-477118 hydrate |
Proteasome
,
DPP-4
|
|
Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM). |
|
T1088 |
Repaglinide
|
AG-EE 388 ZW,AG-EE 623ZW |
Potassium Channel
,
PPAR
|
|
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare... |
|
T5016 |
Tofogliflozin (hydrate)
|
Tofogliflozin hydrate,CSG-452 hydrate |
SGLT
,
Reactive Oxygen Species
,
ROS
|
|
Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2). |
|
T2401 |
Alogliptin Benzoate
|
SYR 322,Alogliptin(SYR-322)benzoate |
Ferroptosis
,
Proteasome
,
DPP-4
|
|
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the... |
|
T1674 |
Nateglinide
|
A4166,Senaglinide |
Potassium Channel
,
Proteasome
,
PPAR
|
|
Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins... |
|
T67849 |
O-Desethyl Dapagliflozin
|
Empagliflozin-4 |
SGLT
|
|
O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM. |
|
T0214 |
Pioglitazone
|
U 72107 |
Ferroptosis
,
PPAR
|
|
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury. |
|
T77781 |
Lotiglipron
|
PF-07081532 |
Glucagon Receptor
|
|
Lotiglipron (PF-07081532) is an orally active and potent GLP-1R agonist that reduces blood glucose and body weight and may be useful in the study of type 2 diabetes mellitus (T2DM) and obesity. |
|
T28743 |
Seglitide acetate
|
MK 678,MK678,MK-678 |
Somatostatin
|
|
Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor. |
|
T1622 |
Rosiglitazone maleate
|
BRL 49653C,BRL 49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
|
T7217 |
Bexagliflozin
|
THR-1442,EGT1442,EGT0001442 |
SGLT
|
|
Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively |
