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T35537 |
Hedgehog Antagonist VIII
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Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript... |
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T3156 |
Ciliobrevin A
|
Hedgehog Pathway Inhibitor 4,HPI-4 |
Hedgehog/Smoothened
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Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM. |
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T75148 |
Hedgehog IN-3
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Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1]. |
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T79055 |
Hedgehog IN-2
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Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1]. |
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T15183 |
Dynarrestin
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Hedgehog/Smoothened
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Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. It inhibits dynein 1-driven microtubule gliding in vitro pl... |
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T3588 |
JK184
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Hedgehog/Smoothened
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JK184 is a potent Hedgehog (Hh) pathway inhibitor. |
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T14965 |
Ciliobrevin D
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ATPase
,
Hedgehog/Smoothened
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Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ... |
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T6891 |
MK-4101
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Apoptosis
,
Hedgehog/Smoothened
,
Smo
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MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. |
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T9531 |
MRT-14
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Smo
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MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies. |
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T2450 |
SANT-1
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SANT 1 |
Hedgehog/Smoothened
,
Smo
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SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). |
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T22814 |
GSA-10
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Hedgehog/Smoothened
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Smoothened (Smo) receptor agonist |
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T2590 |
Vismodegib
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Erivedge,GDC-0449,RG 3616 |
Hedgehog/Smoothened
,
ABC
,
Autophagy
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Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM). |
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T20723 |
LGE-899
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Sonidegib metabolite M48,LGE 899 |
Drug Metabolite
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LGE-899 (Sonidegib metabolite M48) is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib. |
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T26296 |
Triparanol
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MER-29,NSC 65345,NSC-65345,NSC65345 |
Apoptosis
,
Hedgehog/Smoothened
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Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan... |
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T24754 |
Hh-Ag1.5
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SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
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Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
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T77603 |
WAY-313170
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PDE
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WAY-313170 Inhibits hedgehog signaling and phosphodiesterase. |
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T22089 |
HPI 1
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Hedgehog/Smoothened
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HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... |
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T15019 |
CUR61414
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Hedgehog/Smoothened
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CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). |
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T35559 |
SAG 21k
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Hedgehog/Smoothened
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SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration. |
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T2666 |
Taladegib
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LY2940680 |
Hedgehog/Smoothened
,
Smo
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Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
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T64351 |
GI-560192
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RL-0070933 |
Smo
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GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. |
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T21325 |
TAK-441
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TAK441 |
Hedgehog/Smoothened
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TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth. |
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T1779 |
SAG
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Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened
,
Smo
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SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. |
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T9532 |
MRT-81
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Others
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MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance... |
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T1926 |
Sonidegib
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Erismodegib,NVP-LDE225,LDE225 |
Hedgehog/Smoothened
,
Smo
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Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
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T35548 |
Dynapyrazole A
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Dynamin
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Dynapyrazole A is a specific inhibitor of microtubule dynamin with IC50s of 2.3 and 2.6 μM for dynein 1 and dynein 2-dependent microtubule gliding. Dynapyrazole A inhibits Hedgehog signaling with an IC50 of 1.9 μM. |
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T24159 |
IHR-1
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IHR 1 |
Smo
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IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. |
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T3460 |
HhAntag
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Hedgehog/Smoothened
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Smo
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HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity. |
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T63429 |
SMO-IN-2
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Hedgehog/Smoothened
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SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c... |
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T15019L |
CUR61414 hydrochloride
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CUR61414 hydrochloride (334998-36-6 Free base) |
Hedgehog/Smoothened
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CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively... |
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T40465 |
SAG dihydrochloride
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Hedgehog/Smoothened
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SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. |
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T12109 |
MRT-83
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Smo
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MRT-83 is a potent Smo antagonist. |
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T3070 |
GANT 61
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NSC 136476,GANT61 |
Hedgehog/Smoothened
,
Autophagy
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GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2. |
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T23027 |
MRT-10
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Hedgehog/Smoothened
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MRT-10 is a Smoothened (Smo) receptor antagonist. |
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T12797 |
RU-SKI 43
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RUSKI 43 |
Hedgehog/Smoothened
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Acyltransferase
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T5465 |
PF-5274857
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PF-5274857 freebase |
Smo
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PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... |
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T26899 |
BRD50837
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BRD-50837,BRD 50837 |
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BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh). |
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T26901 |
BRD-9526
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BRD 9526 |
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BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh). |
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T34451 |
RUSKI-201
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RU-SKI-201 |
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RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells. |
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T71299 |
M-25
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M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. |
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T23307 |
SANT 2
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SANT-2 |
Others
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SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM). |
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T25918 |
Palmitoyl-L-aspartic acid
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L-N-Palmitoylaspartic acid |
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Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec... |
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T12797L |
RU-SKI 43 hydrochloride
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Others
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RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity. |
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T71455 |
Glasdegib hydrochloride
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Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. |
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T16843 |
Saridegib
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IPI-926,Patidegib |
Others
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Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway. |
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T40755 |
Glabrescione B
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Glabrescione B is a novel compound that specifically binds to Gli1, an important modulator of the Hedgehog (Hh) signaling pathway. By disrupting the Gli1-DNA interaction, Glabrescione B effectively impairs the activity o... |
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T71338 |
Patidegib HCl
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Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specific... |
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T3363L |
Jervine HCl
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Jervine hydrochloride |
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Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervin... |
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T79907 |
HPP-9
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HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET bromodomains and exhibits antitumor activity [1]. |
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T38767 |
MRT-83 hydrochloride
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MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t... |
