Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 8,500 | |||
50 mg | 在庫あり | ¥ 12,500 | |||
100 mg | 在庫あり | ¥ 17,000 | |||
200 mg | 在庫あり | ¥ 27,500 | |||
500 mg | 在庫あり | ¥ 60,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. |
In vitro | In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio. |
In vivo | In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg. |
植物由来 |
別名 | Vegard, Matridin-15-one, Matrinium, α-Matrine, (+)-Matrine |
分子量 | 248.36 |
分子式 | C15H24N2O |
CAS No. | 519-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 49 mg/mL (197.29 mM)
H2O: 11 mg/mL (44.29 mM), Heating is recommended.
DMSO: 45 mg/mL (181.18 mM)
You can also refer to dose conversion for different animals. 詳細
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Matrine 519-02-8 Apoptosis Autophagy Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Mitophagy Ferroptosis Vegard Inhibitor Matridin-15-one anti-oxidative stress Mitochondrial Autophagy Matrinium α-Matrine alpha-Matrine A549 cells acute kidney injury (AKI) model Non-small cell lung cancer hepatoma (+)-Matrine inhibit a-Matrine inhibitor