Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 33,000 | |||
10 mg | 在庫あり | ¥ 49,000 | |||
25 mg | 在庫あり | ¥ 82,500 | |||
50 mg | 在庫あり | ¥ 121,500 | |||
100 mg | 在庫あり | ¥ 173,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 38,500 |
説明 | Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. |
In vitro | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1] |
植物由来 |
分子量 | 418.52 |
分子式 | C24H34O6 |
CAS No. | 10351-88-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (131.42 mM)
You can also refer to dose conversion for different animals. 詳細
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Phyllanthin 10351-88-9 NF-Κb NF-κB hepatoprotective inhibit bioactive antioxidative Phyllanthus Inhibitor amarus lignan inhibitor