| TN1644 |
Flavanomarein
|
|
Others
|
|
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea... |
| TN1911 |
Marein
|
|
transporter
,
Akt
,
HDAC
,
AMPK
|
|
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... |
| T5669 |
Citric acid monohydrate
|
|
Others
|
|
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a... |
| T5S0636 |
Citric acid
|
Citro,Citretten |
Apoptosis
,
Others
,
Endogenous Metabolite
,
Antibacterial
,
Antibiotic
|
|
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... |
| TN2062 |
Phyllanthin
|
|
NF-κB
|
|
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. |
| T2763 |
Panaxadiol
|
20(R)-Panaxadiol |
Others
,
HIF/HIF Prolyl-Hydroxylase
|
|
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng. |
| T5S2059 |
Glaucine
|
|
Calcium Channel
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
PDE
|
|
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... |
| T6S1525 |
3,4-Dicaffeoylquinic acid
|
Isochlorogenic acid B |
Apoptosis
,
Antioxidant
,
Influenza Virus
,
Endogenous Metabolite
|
|
3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity. |
| T2S0961 |
Chalcone
|
benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone |
EGFR
,
Antibacterial
|
|
Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. |
| T3388 |
Calycosin-7-O-β-D-glucoside
|
calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside |
MMP
,
Reactive Oxygen Species
|
|
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos... |
| Fr16745 |
4-Hydroxybenzyl cyanide
|
4-Hydroxyphenylacetonitrile |
Endogenous Metabolite
|
|
4-Hydroxybenzyl cyanide (4-Hydroxyphenylacetonitrile) shows strong antioxidative activity. |
| T4957 |
Carnosic acid
|
|
Apoptosis
,
ROS
,
Antibacterial
|
|
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties. |
| T16747 |
Riboflavin Tetrabutyrate
|
|
Reactive Oxygen Species
|
|
|
| T5648 |
Purpurin
|
1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin |
MAO
,
Antibacterial
,
Antibiotic
,
Antifungal
|
|
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. |
| T5545 |
Maltol
|
Veltol,Larixinic acid,Palatone |
Antioxidant
,
Endogenous Metabolite
|
|
Maltol (Palatone) is a naturally occurring organic compound that is flavour enhancer and flavouring agent. Maltol (Palatone) also is a potent antioxidative agent. |
| T3825 |
Lobetyolin
|
Praeruptorin D |
Others
|
|
Lobetyolin (Praeruptorin D) is compound derived from Codonopsis pilosula with antioxidative effect. |
| T4S1718 |
Punicalin
|
|
HBV
,
HIV Protease
|
|
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM). |
| T6S1930 |
Schisanhenol
|
Schizanhenol,Gomisin-K3 |
Antioxidant
|
|
1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanheno... |
| T8087 |
Tropolone
|
|
Tyrosinase
|
|
Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion |
| TN1160 |
1,2,3,6-Tetragalloylglucose
|
1,2,3,6-Tetra-O-galloyl-β-D-glucose,TeGG |
LDL
,
UGT
|
|
1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransfera... |
| T3903 |
Angoroside C
|
|
Prostaglandin Receptor
|
|
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and ... |
| T2770 |
Gentiopicroside
|
Gentiopicrin |
P450
,
HCV Protease
|
|
Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatorya... |
| T4S0792 |
Pinoresinol 4-O-β-D-glucopyranoside
|
(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside |
Others
|
|
(+)-Pinoresinol-β-D-glucoside, also known as (+)-pinor, is a major active lignan furanoid found in Forsythia. It exhibits antioxidative, antihypertensive activities, and acts as an inhibitor of cyclic adenosine monophosp... |
| T5834 |
Myrcene
|
|
Others
|
|
Myrcene is a terpene that has been found in Cannabis and has antioxidative properties. |
| TN4583 |
Moringin
|
|
gp120/CD4
,
IL Receptor
,
BCL
,
GSK-3
,
TNF
,
Wnt/beta-catenin
,
Caspase
,
COX
,
Nrf2
,
PPAR
,
p53
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moringin has anti-inflammatory and antioxidative properties. |
| T5796 |
Plantainoside D
|
Isoplantamajoside |
RAAS
,
PKC
|
|
Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ... |
| T16527 |
Phytic acid dodecasodium salt hydrate
|
myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate |
Others
,
Xanthine Oxidase
,
Endogenous Metabolite
|
|
Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits th... |
| T6102 |
2'-acetylacteoside
|
|
Antioxidant
,
Reductase
|
|
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo... |
| T8072 |
S-Methyl-L-cysteine
|
S-Methylcysteine |
Antioxidant
,
Reactive Oxygen Species
|
|
S-Methyl-L-cysteine (S-Methylcysteine) is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with neuroprotective, antioxidative, and anti-... |
| T3857 |
Magnolin
|
(+)-Magnolin |
ERK
|
|
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects. |
| T3907 |
Tenuigenin
|
Senegenin,Senegin |
NF-κB
,
Caspase
,
Antibacterial
|
|
Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity. |
| T2771 |
Orcinol glucoside
|
Sakakin |
Antioxidant
|
|
Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects. |
| T2212 |
Geniposide
|
|
Beta Amyloid
,
Influenza Virus
|
|
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation... |
| T3743 |
4-hydroxyphenylacetic acid
|
p-Hydroxyphenylacetic acid,parahydroxy phenylacetate |
Antioxidant
,
Nrf2
,
Endogenous Metabolite
|
|
4-hydroxyphenylacetic acid (parahydroxy phenylacetate) is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid(p-Hydroxyphenylacetic acid) is involved in the antioxidative action. 4-hydroxyphe... |
| T1716 |
Echinacoside
|
|
Reactive Oxygen Species
,
Wnt/beta-catenin
|
|
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat... |
| T39887 |
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid
|
(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid |
Others
|
|
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) (compound 1) is a metabolite found in the culture medium of Leuconostoc mesenteroides . (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid... |
| TN1873 |
Lirinidine
|
|
Others
|
|
(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesis. Lirinidine exhibits significant inhibition of collagen, a... |
| TN1928 |
Methyl rosmarinate
|
|
MMP
,
Anti-infection
,
Tyrosinase
|
|
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has... |
| T4S0094 |
Hydroxygenkwanin
|
Luteolin 7-methylether,7-O-Methylluteolin |
Antioxidant
|
|
1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin a... |
| T1082 |
Benzyl isothiocyanate
|
Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester |
Apoptosis
,
Antibacterial
,
Antibiotic
|
|
Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog... |
| T3S0645 |
N-trans-Feruloyltyramine
|
Feruloyltyramine,N-Feruloyltyramine,Moupinamide |
Others
,
COX
|
|
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... |
| T2909 |
Fraxetin
|
7,8-dihydroxy-6-methoxy coumarin |
Apoptosis
,
Others
|
|
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m... |
| T6S0525 |
Farrerol
|
|
ERK
,
p38 MAPK
,
Akt
|
|
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3.... |
| T6S0221 |
Eriocitrin
|
eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside |
Apoptosis
,
Carbonic Anhydrase
|
|
1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet.... |
| T2924 |
Phloretin
|
Dihydronaringenin,NSC 407292,RJC 02792 |
SGLT
,
transporter
,
Endogenous Metabolite
|
|
Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav... |
| T3S0209 |
Vincristine
|
|
ERK
,
p38 MAPK
,
NF-κB
,
Akt
,
JNK
,
mTOR
|
|
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristine can treat MM, ERK1/2, Akt, and NF-κB inhibitors are pote... |
| TN2387 |
7,8,9,9-Tetradehydroisolariciresinol
|
|
Antioxidant
|
|
7,8,9,9-Tetradehydroisolariciresinol has antioxidative activity |
| TN6488 |
Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside
|
|
|
|
Orcinol 1-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside has antioxidative activity. |
| T81009 |
Tetrahydroauroglaucin
|
|
|
|
Tetrahydroauroglaucin, a hydroquinone derivative, exhibits antioxidative effects [1]. |
| TN1376 |
α-Solanine
|
alpha-Solanine |
MMP
,
Akt
,
PI3K
|
|
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut. |
