Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
説明 | Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53. |
In vitro | Pifithrin-α, p-Nitro, Cyclic (PFN-α) effectively inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons when exposed to etoposide, requiring concentrations an order of magnitude lower compared to PFT-α[1]. |
In vivo | Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1]. |
別名 | PFN-α |
分子量 | 299.35 |
分子式 | C15H13N3O2S |
CAS No. | 60477-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (16.70 mM), Sonication is recommended.
DMF: 12.5 mg/mL (41.76 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Pifithrin-α, p-Nitro, Cyclic 60477-38-5 Apoptosis p53 MDM-2/p53 PFN-α Inhibitor expression p21 neurons cortical Pifithrin-a, p-Nitro, Cyclic WAF1 Pifithrinα, pNitro, Cyclic inhibit death p53-triggered PFN-alpha posttranscriptional cell Pifithrin-alpha, p-Nitro, Cyclic Pifithrin α, p Nitro, Cyclic PFN-a inhibitor