Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
説明 | R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. |
ターゲット&IC50 | CDK4-CyclinD1:1 nM(Ki), CDK2-CyclinE:3 nM(Ki), CDK1-CyclinB:2 nM(Ki) |
別名 | Ro 4584820 |
分子量 | 441.45 |
分子式 | C18H21F2N5O4S |
CAS No. | 741713-40-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 56 mg/mL (126.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
R547 741713-40-6 Apoptosis Cell Cycle/Checkpoint PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors GSK-3 PKA CDK Glycogen synthase kinase 3 kinase multiple tumor cyclin-dependent R 547 Cyclin dependent kinase human Inhibitor Ro 4584820 Glycogen synthase kinase-3 R-547 inhibit inhibitor