Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 29,500 | |||
5 mg | 在庫あり | ¥ 80,000 | |||
10 mg | 在庫あり | ¥ 121,500 | |||
25 mg | 在庫あり | ¥ 197,500 | |||
50 mg | 在庫あり | ¥ 273,500 | |||
100 mg | 在庫あり | ¥ 363,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 88,000 |
説明 | Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers. |
ターゲット&IC50 | PKC:10 μM(Ki) |
In vitro | Sangivamycin (0.3 μM; 0-72 hours) exhibits a predominantly cytocidal effect in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, and a cytostatic effect in drug-sensitive MCF7/wild type (WT) cells. In MCF7/ADR cells, Sangivamycin triggers caspase activation, leading to significant cleavage of lamin A into a 28-kDa fragment within 48 hours. These findings highlight Sangivamycin's differential antitumor activities, inducing apoptosis-driven cell death in MCF7/ADR cells and growth arrest in MCF7/WT cells. |
別名 | BA-90912, NSC 65346 |
分子量 | 309.28 |
分子式 | C12H15N5O5 |
CAS No. | 18417-89-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (307.17 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Sangivamycin 18417-89-5 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog PKC cells antitumor BA-90912 NSC-65346 MCF7 Inhibitor BA 90912 Protein kinase C BA90912 nucleoside inhibit analog NSC65346 NSC 65346 antiproliferative inhibitor