Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
2 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 24,000 | |||
10 mg | 在庫あり | ¥ 43,500 | |||
25 mg | 在庫あり | ¥ 87,000 | |||
50 mg | 在庫あり | ¥ 133,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. |
ターゲット&IC50 | Autophagy:, VPS34:1.2 nM, VPS34:1.5 nM (kd) |
In vitro | SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases. Inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. SAR405 prevents autophagosome formation (IC50: 42 nM). Treatment of starved cells with SAR405 fully inhibits the conversion to LC3-II in a dose-dependent manner. The GFP-LC3 model is used for the HTS and confirmed its activity on starved cells (IC50=419 nM) [1][2]. |
分子量 | 443.85 |
分子式 | C19H21ClF3N5O2 |
CAS No. | 1523406-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27 mg/mL (60.83 mM)
You can also refer to dose conversion for different animals. 詳細
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SAR405 1523406-39-4 Autophagy PI3K/Akt/mTOR signaling PI3K inhibit Inhibitor Phosphoinositide 3-kinase SAR 405 SAR-405 inhibitor