Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 35,500 | |||
10 mg | 在庫あり | ¥ 57,000 | |||
25 mg | 在庫あり | ¥ 96,000 | |||
50 mg | 在庫あり | ¥ 137,000 | |||
100 mg | 在庫あり | ¥ 198,000 |
説明 | Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
In vitro | Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus. |
植物由来 |
分子量 | 359.8 |
分子式 | C19H18ClNO4 |
CAS No. | 96087-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (13.89 mM)
You can also refer to dose conversion for different animals. 詳細
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Stylopine hydrochloride 96087-21-7 Immunology/Inflammation Neuroscience COX NOS alkaloid (±)-Stylopine Corydalis Inhibitor Tetrahydrocoptisine anti-parasitic inhibit Stylopine Hydrochloride inhibitor