Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS0728 is a HER2 inhibitor, with antitumor activity
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 43,500 | |||
10 mg | 在庫あり | ¥ 68,500 | |||
25 mg | 在庫あり | ¥ 129,500 | |||
50 mg | 在庫あり | ¥ 206,000 | |||
100 mg | 在庫あり | ¥ 280,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | TAS0728 is a HER2 inhibitor, with antitumor activity |
ターゲット&IC50 | EGFR:65 nM , BLK:31 nM , HER2 (human):36 nM , JAK3:33 nM, BMX:4.9 nM , HER2:13 nM , HER4:8.5 nM |
In vitro | TAS0728 exhibited robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors, thereby inducing apoptosis of HER2-amplified breast cancer cells and in tumor tissues of a xenograft model.?TAS0728 induced tumor regression in mouse xenograft models bearing HER2 signal-dependent tumors and exhibited a survival benefit without any evident toxicity in a peritoneal dissemination mouse model bearing HER2-driven cancer cells[1]. |
分子量 | 504.58 |
分子式 | C26H32N8O3 |
CAS No. | 2088323-16-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (247.73 mM)
You can also refer to dose conversion for different animals. 詳細
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TAS0728 2088323-16-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER Inhibitor TAS 0728 ErbB-1 inhibit HER1 TAS-0728 Epidermal growth factor receptor inhibitor