Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 7,000 | |||
50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 13,500 | |||
200 mg | 在庫あり | ¥ 18,000 | |||
500 mg | 在庫あり | ¥ 27,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
In vivo | In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2] |
細胞研究 | Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter. |
動物実験 | Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection |
別名 | Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, TUDC, Sodium Tauroursodeoxycholate (TUDC) |
分子量 | 521.69 |
分子式 | C26H44NNaO6S |
CAS No. | 35807-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL(19.2 mM)
DMSO: 55 mg/mL (105.43 mM)
H2O: 92 mg/mL (176.3 mM)
You can also refer to dose conversion for different animals. 詳細
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