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Search Results for " tetracyclic "

ターゲット

5-HT Receptor Adrenergic Receptor AChR Norepinephrine Autophagy Histamine Receptor

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T0172	Maprotiline hydrochloride	Maprotiline HCl,Psymion,Deprilept,Ludiomil	5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Autophagy , Histamine Receptor
	Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
T0137	Mirtazapine	6-Azamianserin,Org3770	Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
	Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h...
T21428	Mianserin	Lantanon,Lumin,Norval,Lerivon,Depnon	Histamine Receptor
	Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistam...		Histamine Receptor
T28666	Savoxepin mesylate	CGP-19486A,CGP 19486A,Savoxepin mesilate
	Savoxepin mesylate, a tetracyclic cyano-dibenzoxepino-azepine derivative, has potent antidopaminergic activity.
T32365	Kaurene
	Kaurene is a tetracyclic diterpene.
T26472	A23887	A-23887,A 23887
	A23887 is a potentially neuroleptic tetracyclic spiro amine that has affinity for dopamine D-2 receptors.
T33215	Masticadienediol
	Masticadienediol is a tetracyclic triterpene.
T11744	KB-5246		Ras
			Ras
T26415	A 31472	A31472,A-31472
	A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors.
T68924	Citatepine
	Citatepine is a tetracyclic dopamine antagonist acting strongly antidopaminergic opposed to antiserotonergic. Some anticholinergic activity.
T37161	8-hydroxy Amoxapine
	8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2 1.Johnson, S.M., Nygard, G., and Khalil, S.K.Isocratic liquid chromatographic method for the determination of amoxapine and its metabol...
T30108	Aptazapine maleate	CGS7525A,CGS-7525A,CGS 7525A
	Aptazapine (CGS 7525A) is a tetracyclic antidepressant (TECA) that is a potent α2-adrenergic receptor antagonist and has also been shown to act as a 5-HT2 receptor antagonist and an H1 receptor reverse agonist, both for ...
T63633	Lp-PLA2-IN-6
	Lp-PLA2-IN-6 is a tetracyclic pyrimidinone compound that is a potent inhibitor of Lp-PLA2 and is able to act on rhLp-PLA2 (pIC50: 10.0). lp-PLA2-IN-6 has shown research potential in neurodegenerative diseases.
T63931	Lp-PLA2-IN-9
	Lp-PLA2-IN-9 (compound 17) is a tetracyclic pyrimidinone compound, a potent inhibitor of Lp-PLA2 that acts on rhLp-PLA2 (pIC50: 10.1). lp-PLA2-IN-9 has shown research potential in neurodegenerative diseases.
T83019	Antiproliferative agent-38
	Antiproliferative Agent-38 (COM 18), a tetracyclic compound, features a reactive ring nitrogen (likely the quinoline moiety) that resists N-alkylation. Despite its classification, it neither exhibits anti-malarial proper...

Compounds

Maprotiline hydrochloride

T0172

Synonym: Maprotiline HCl,Psymion,Deprilept,Ludiomil

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor

Mirtazapine

T0137

Synonym: 6-Azamianserin,Org3770

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Mianserin

T21428

Synonym: Lantanon,Lumin,Norval,Lerivon,Depnon

Target: Histamine Receptor

Savoxepin mesylate

T28666

Synonym: CGP-19486A,CGP 19486A,Savoxepin mesilate

Synonym: A-23887,A 23887

Synonym: A31472,A-31472

Synonym: CGS7525A,CGS-7525A,CGS 7525A

Antiproliferative agent-38

T83019

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
TN1006	Tirucallol		NOS , NO Synthase , Prostaglandin Receptor
	Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.		NOS , NO Synthase , Prostaglandin Receptor
T5S0658	Corynoxine		Autophagy
	Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.		Autophagy
TN2341	Cucurbitacin Q1		Others
	Cucurbitacin Q1, a compound isolated from the fruit of Cucumis prophetarum, has been shown to be the pure trans component of cucurbitacin Q.		Others
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T0783	Mianserin hydrochloride	Mianserin HCl,Org GB 94,ORG GB-94 HCl	Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
	Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematolog...
T4970	LANOSTEROL	3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.		Endogenous Metabolite
T5737	Euphol		Others , Lipase , Endogenous Metabolite
	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.		Others , Lipase , Endogenous Metabolite
T3332	Isosteviol	(-)-Isosteviol	IL Receptor , Potassium Channel , TNF , NF-κB , Reactive Oxygen Species , COX , Topoisomerase
	Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and stevio...
T12517	Polyketomycin		Others
			Others
T31910	Ganoderiol A	(+)-Ganoderiol A
	Ganoderiol A is a tetracyclic triterpene extracted from Ganoderma amboinense.
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer. It facilitates the removal of alpha-synuclein by activating the Akt/mT...
T72533	4-Deoxy-4α-phorbol
	4-Deoxy-4α-phorbol, a tetracyclic diterpene identified in E. desmondi, serves as a precursor in the semisynthesis of compounds inhibiting HIV-1-induced cytopathic effects in MT-4 cells and the creation of 4α-phorbol este...