Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Y-320 is a new phenylpyrazoleanilide immunomodulator.
説明 | Y-320 is a new phenylpyrazoleanilide immunomodulator. |
ターゲット&IC50 | IL-17 production:20-60 nM |
In vitro | Y-320 can inhibit the production of IFN-γ and TNF-α in mouse CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 monoclonal antibody. |
In vivo | Y-320 (administered orally at doses of 0.3-3 mg/kg) enhances the improvement of collagen-induced arthritis (CIA) in mice, concurrently reducing the expression levels of IL-17 mRNA within arthritic joints. Additionally, it has demonstrated therapeutic efficacy for CIA in crab-eating macaques. |
別名 | Y320 |
分子量 | 505.01 |
分子式 | C27H29ClN6O2 |
CAS No. | 288250-47-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 9 mg/mL (17.8 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Y-320 288250-47-5 Immunology/Inflammation Metabolism Interleukin Lipase IL Receptor Interleukin Related anticancer Y320 phenylpyrazoleanilide Y 320 G418 inhibit Apoptosis immunomodulator rheumatoid arthritis protein synthesis Inhibitor inhibitor