|
T1846 |
Y-320
|
Y320 |
IL Receptor
,
Lipase
,
Interleukin
|
|
Y-320 is a new phenylpyrazoleanilide immunomodulator. |
|
T21694 |
(R)-Lisofylline
|
(R)-Lisophylline |
STAT
|
|
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat... |
|
T6561 |
Laquinimod
|
LAQ,ABR-215062 |
Apoptosis
,
Others
,
NF-κB
|
|
Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy. |
|
T16913 |
Sotirimod
|
R850,S-30594 |
Virus Protease
|
|
Sotirimod（R850） is a novel immunomodulator with antitumor and antiviral activity for the study of actinic keratoses. |
|
T4640 |
Parimifasor
|
LYC30937 |
Others
|
|
Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity. |
|
T25705 |
Imupedone
|
LF1695,LF-1695,LF 1695 |
Others
|
|
Imupedone (LF 1695) is a synthetic immunomodulator that modulates T lymphocytes and macrophages, induces T-cell differentiation of bone marrow precursor cells, and increases the proliferative response of lymphocytes to m... |
|
T31648 |
Epetirimod
|
S 30563,S-30563,S30563 |
Antiviral
|
|
Epetirimod (S-30563) is a small molecule immunomodulator with antitumor and anti-infective activity for the study of papillomavirus infections. |
|
T18819 |
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
|
|
Others
,
Ligand for E3 Ligase
|
|
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immunomodulator for the treatment of cancer. |
|
T14846 |
Bz 423
|
BZ48 |
Apoptosis
,
BCL
|
|
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus... |
|
T2384 |
Pomalidomide
|
CC-4047 |
Apoptosis
,
TNF
,
Ligand for E3 Ligase
,
Molecular Glues
|
|
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. |
|
T6761 |
Ossirene
|
AS101 |
IL Receptor
,
Caspase
,
Interleukin
|
|
Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. |
|
T68043 |
Ciamexon
|
Ciamexone,BM 41332,BM41332,BM-41332 |
Others
|
|
Ciamexon (Ciamexone) is a novel immunomodulator that has shown promising results in experimental models of autoimmune disease with little demonstrated cytotoxicity.Ciamexon can be used to study endocrine ophthalmopathies... |
|
T34249 |
Rabeximod
|
ROB-803 |
TLR
|
|
Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by stimulating TLR2 and TLR4 downstream to block the activatio... |
|
T3655 |
BMS-1
|
PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1 |
Apoptosis
,
PD-1/PD-L1
|
|
BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene ... |
|
T13666 |
Dupilumab
|
REGN-668,SAR-231893 |
IL Receptor
|
|
Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and... |
|
T28087 |
Mosedipimod
|
|
|
|
Mosedipimod is an immunomodulator. |
|
T31847 |
Forfenimex
|
BF 121,BF-121,BF121 |
|
|
Forfenimex is a newly discovered low molecular weight immunomodulator. |
|
T31594 |
EA-230
|
EA 230,NMPF-46,NMPF46,NMPF 46 |
|
|
Ea-230 is an immunomodulator that may be used in the treatment of renal failure. |
|
T73284 |
Vonifimod
|
|
|
|
Vonifimod is an immunomodulator . |
|
T39375 |
Thalidomide-O-amido-PEG2-C2-NH2
|
Cereblon Ligand-Linker Conjugates 10,E3LigaseLigand-LinkerConjugates24,Thalidomide-O-amido-PEG2-C2-NH2 |
|
|
Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment. |
|
T70189 |
Navoximod phosphate
|
|
|
|
Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic. |
|
T24092 |
Glufanide disodium
|
IM 862,Oglufanide disodium,IM862,IM-862 |
|
|
Glufanide disodium is an immunomodulator. |
|
T20799 |
Lobenzarit
|
Lobenzaritum |
|
|
Lobenzarit, an immunomodulator, is most frequently used to treat arthritis. Its chemical scaffold has been repurposed to tryptophan biosynthesis in Mycobacterium tuberculosis |
|
T81023 |
Tegomil fumarate
|
|
|
|
Tegolimod fumarate is an immunomodulator [1]. |
|
T25270 |
Conagenin
|
|
|
|
Conagenin is a small molecular immunomodulator isolated by Streptomyces roseosporus. |
|
T12037 |
Mifamurtide
|
L-MTP-PE,MTP-PE,CGP 19835 |
Others
|
|
Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects. |
|
T27350 |
Fosmetpantotenate
|
RE-024,RE024,RE 024 |
|
|
Fosmetpantotenate, a immunomodulator, is used for treatment of Pantothenate Kinase Associated Neurodegeneration (PKAN). |
|
T82593 |
Debotansine
|
|
|
|
"Debotansine, an immunomodulator and antineoplastic [1], is a chemical compound with therapeutic applications in modulating the immune system and combating cancer." |
|
T12386 |
PD-1-IN-18
|
|
Others
|
|
PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator. |
|
T77004 |
Faralimomab
|
|
|
|
Faralimomab (64G12) is an immunomodulator, and a murine anti- IFNA1 IgG1 mAb [1] . |
|
T72869 |
IMD-biphenylA
|
|
NF-κB
|
|
IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune potentiators. |
|
T27968 |
M-5011
|
T-3788,S-MTPPA,M 5011,M-5011C |
|
|
M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially i... |
|
T82375 |
Fosimdesonide
|
|
|
|
Fosimdesonide, a small molecule analog of adalimumab, serves as a potent immunomodulator with demonstrated anti-inflammatory activity [1]. |
|
T25319 |
Diacetylsplenopentin HCl
|
Diacetylsplenopentin hydrochloride |
|
|
Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the imm... |
|
T38614 |
TLR7 agonist 3
|
|
|
|
TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development. |
|
T78292 |
Ifinatamab
|
Anti-Human B7-H3 |
|
|
Ifinatamab is a monoclonal immunoglobulin G1-kappa antibody that targets the human B7-H3 protein (B7 homolog 3). It functions as a glycoform α immunomodulator [1]. |
|
T74747 |
Tamuzimod
|
|
|
|
Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2]. |
|
T73696 |
Peginterferon alfa-2b
|
|
|
|
Peginterferon alfa-2b (Sch 54031), a recombinant alfa-2b interferon covalently bonded to polyethylene glycol (PEG), acts as an immunomodulator. This compound is effective in reducing viral DNA in HIV and has potential ap... |
|
T74905 |
ODN 2007
|
|
|
|
ODN 2007, a class B CpG ODN (oligodeoxynucleotide) and Toll-like receptor (TLR) ligand, serves as an immunomodulator and vaccine adjuvant, promoting enhanced immune responses across mammals, fish, and humans. Its sequenc... |
|
T76811 |
Imgatuzumab
|
|
|
|
Imgatuzumab (RG 7160), a humanized monoclonal antibody targeting the epidermal growth factor receptor (EGFR), serves as an immunomodulator. It is utilized in cancer research [1]. |
|
T77000 |
Cirevetmab
|
|
|
|
Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa. It functions as an immunomodulator [1]. |
|
T72870 |
IMD-biphenylB
|
|
NF-κB
|
|
IMD-biphenylB, an imidazoquinolinone-based dimer, acts as a potent NF-κB immunomodulator, inhibiting tumor proliferation with minimal systemic inflammation and decreased adjuvant toxicity. |
|
T72871 |
IMD-biphenylC
|
|
NF-κB
|
|
IMD-biphenylC is a novel imidazoquinolinone dimer functioning as an NF-κB immunomodulator. It effectively inhibits tumor proliferation and simultaneously induces minimal systemic inflammation with reduced adjuvant toxici... |
|
T81738 |
Murabutide
|
|
|
|
Murabutide, a safe synthetic immunomodulator, diminishes the expression of CD4 and CCR5 receptors and promotes the secretion of high levels of beta-chemokines, thereby enhancing nonspecific resistance to viral infections... |
|
T78053 |
PD-L1-IN-2
|
|
PD-1/PD-L1
|
|
PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell... |
|
T74089 |
Mifamurtide TFA
|
|
|
|
Mifamurtide TFA (MTP-PE TFA), a muramyl dipeptide (MDP) analog, acts as a nonspecific immunomodulator by activating macrophages and monocytes to stimulate the immune response. As an orphan agent and a specific NOD2 ligan... |
|
T61607 |
Laquinimod sodium
|
|
|
|
Laquinimod (ABR-215062) sodium is a carboxamide derivative administered orally that serves as a powerful immunomodulator, designed to prevent inflammation and neurodegeneration within the central nervous system. This com... |
|
T81942 |
Lenalidomide sodium
|
CC-5013 sodium |
|
|
Lenalidomide (sodium), a Thalidomide derivative, serves as a molecular glue and an orally active immunomodulator. It acts as a cereblon (CRBN) ligand and triggers selective ubiquitination and subsequent degradation of th... |
|
T21763 |
Lenalidomide hydrochloride
|
|
|
|
Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facili... |
