|
T39764 |
ALK2-IN-4
|
ALK2-IN-4 |
|
|
ALK2-IN-4, a highly effective ALK2 inhibitor. |
|
T10287 |
ALK2-IN-2
|
|
ALK
,
TGF-beta/Smad
|
|
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3. |
|
T40065 |
ALK2-IN-4 succinate
|
ALK2-IN-4 succinate |
|
|
ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2. |
|
T8108 |
Blu-782
|
ALK2-IN-1 |
ALK
|
|
Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM) |
|
T79020 |
ALK2-IN-5
|
|
|
|
ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1]. |
|
T1943 |
ML347
|
LDN 193719 |
ALK
,
TGF-beta/Smad
|
|
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. |
|
T1944 |
LDN-214117
|
|
ALK
,
TGF-beta/Smad
|
|
LDN-214117 is a potent and selective ALK2 inhibitor. |
|
T35694 |
OD36
|
OD 36,OD 36 hydrochloride,OD-36 |
ALK
,
RIP kinase
|
|
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. |
|
T1900 |
LDN-212854
|
LDN212854,BMP Inhibitor III |
ALK
,
TGF-beta/Smad
|
|
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. |
|
T1935 |
LDN193189
|
LDN-193189,DM-3189,LDN 193189 |
ALK
,
TGF-beta/Smad
|
|
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). |
|
T1942 |
DMH-1
|
DMH1 |
ALK
,
Autophagy
,
TGF-beta/Smad
|
|
DMH-1 is a potent and selective BMP inhibitor. |
|
T35348 |
LDN-193189 2HCl
|
LDN-193189 2HCl,DM-3189 2HCl |
ALK
,
TGF-beta/Smad
|
|
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ... |
|
T1977 |
Dorsomorphin
|
Compound C,BML-275 |
AMPK
,
Autophagy
,
TGF-beta/Smad
|
|
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ... |
|
T1914 |
K02288
|
K 02288 |
ALK
,
TGF-beta/Smad
|
|
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6. |
|
T6146 |
Dorsomorphin dihydrochloride
|
BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride |
AMPK
,
Autophagy
,
TGF-beta/Smad
|
|
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases. |
|
T6496 |
Vactosertib
|
TEW-7197,EW-7197 |
ALK
,
TGF-beta/Smad
|
|
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... |
|
T61424 |
OD36 hydrochloride
|
OD 36 hydrochloride,OD-36 hydrochloride |
ALK
,
RIP kinase
|
|
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antago... |
|
T39104 |
Itacnosertib
|
Itacnosertib,TP-0184 |
|
|
Itacnosertib (TP-0184) is a chemical compound that acts as an inhibitor of JAK2, ACVR1 (ALK2), and ALK5, as indicated in WO2014151871. |
|
T74660 |
M4K2234
|
|
|
|
M4K2234 (compound 26b), an ALK2 inhibitor, demonstrates selective inhibition of ALK2 and ALK5 with IC50 values of 5 nM and 2144 nM, respectively. Serving as a chemical probe for ALK1 and ALK2 protein kinases, M4K2234 hol... |
|
T81410 |
Prafnosbart
|
DS-6016A |
|
|
Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized in research on bone metabolism disorders [1]. |
|
T62783 |
RIPK2-IN-1
|
|
|
|
RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM). |
|
T6158 |
LDN-193189 HCl
|
LDN193189 Hydrochloride |
ALK
|
|
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor. |
|
T63897 |
LDN193189 Tetrahydrochloride
|
|
|
|
LDN193189 Tetrahydrochloride is a selective inhibitor of BMPI-type receptors and inhibits ALK2 (IC50: 5 nM) and ALK3 (IC50: 30 nM), with weak effects on ALK4, ALK5 and ALK7 (IC50 ≥ 500 nM). |
|
T15262 |
Vactosertib Hydrochloride
|
TEW-7197 Hydrochloride,EW-7197 Hydrochloride |
ALK
|
|
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50... |
|
T73490 |
MU1700
|
|
|
|
MU1700, an orally active and potent inhibitor targeting ALK1/2, exhibits IC50 values of 13 nM for ALK1 and 6 nM for ALK2. It demonstrates both cell membrane and high brain permeability. |
|
T81740 |
Multi-kinase-IN-6
|
|
Trk receptor
|
|
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX ca... |
