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T25140 |
BCH 2763
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BCH2763,BCH-2763 |
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BCH 2763 is an effective, selective bifunctional thrombin inhibitor that blocks both the anion binding exosite and the active catalytic site. |
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T11820 |
LAT1-IN-1
|
BCH |
Apoptosis
,
Others
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LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral... |
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T0682 |
Lamivudine
|
GR109714X,BCH-189 |
HIV Protease
,
Reverse Transcriptase
|
|
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. |
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T33891 |
PBI-1393
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PBI1393,BCH1393,BCH 1393,BCH-1393,PBI 1393 |
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PBI-1393 can be used as an enhancer for Th1 type cytokine production and primary T cell activation. |
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T8647 |
BCH001
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|
DNA/RNA Synthesis
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BCH001 is a specific small-molecule inhibitor of PAPD5. |
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T28833 |
SPD-756
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SPD 756,BCH13520,BCH-13520,BCH 13520 |
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SPD-756, a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection. |
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T29149 |
VX 759
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VCH759,BCH27759,VX-759,VX759,VCH-759,BCH-27759 |
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|
VX 759, a nonstructural protein 5B (NS5B) inhibitor, is used potentially for the treatment of HCV infection. |
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T17175 |
Troxacitabine
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BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC |
Others
|
|
Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious ... |
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T61969 |
AChE/BChE-IN-10
|
|
AChR
,
AChE
|
|
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation... |
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T60891 |
AChE/BChE/MAO-B-IN-1
|
|
MAO
,
AChE
|
|
AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1... |
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T62336 |
BChE-IN-3
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|
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BChE-IN-3 is a selective, selective, time-dependent, pseudo-irreversible inhibitor of BChE butyrylcholinesterase (IC50: 56.9 nM).BChE-IN-3 exhibits borderline reversible (time-independent) inhibition of AChE acetylcholin... |
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T60831 |
AChE/BChE-IN-3 hydrochloride
|
|
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AChE/BChE-IN-3 (BMC-1) hydrochloride is an AChE and BChE dual inhibitor. The IC50 values of AChE/BChE-IN-3 against equine serum BChE (eqBChE) and electric eel AChE (elAChE) is 0.383 μM and 6.08 μM, respectively [1]. |
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T61669 |
BChE-IN-4
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|
|
|
BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic a... |
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T62274 |
AChE/BChE-IN-2
|
|
|
|
AChE/BChE-IN-2 (Compound 13b) is a potent inhibitor of AChE/BChE with IC50 values of 0.96 ± 0.14 μM and 1.23 ± 0.23 μM for AChE and BChE, respectively. |
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T73184 |
BChE-IN-15
|
|
|
|
BChE-IN-15 is a compound characterized as a pseudo-irreversible, covalent inhibitor of butyrylcholinesterase (BChE), demonstrating potent activity with an inhibitory concentration (IC50) of 1.76 nM against human BChE (hB... |
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T62504 |
BChE-IN-8
|
|
|
|
BChE-IN-8 (compound 20) is an orally active BChE (butyrylcholinesterase) inhibitor that crosses the blood-brain barrier and acts on eqBChE (IC50: 0.15 nM), hBChE (IC50: 45.2 nM). BChE-IN-8 can be used in the study of Alz... |
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T13242 |
UbcH5c-IN-1
|
|
Others
|
|
UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85). |
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T72452 |
AChE/BChE/MAO-B-IN-2
|
|
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AChE/BChE/MAO-B-IN-2 is a potent inhibitor of the enzymes AChE, BChE, and MAO-B, with IC50 values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. It exhibits significant antioxidant activity and is applicable in Parkinso... |
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T78695 |
BChE-IN-16
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|
|
|
BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) exhibiting an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity and potential for central nervo... |
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T78799 |
BChE/HDAC6-IN-1
|
|
HDAC
|
|
BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42... |
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T64156 |
AChE/BChE-IN-1
|
|
|
|
AChE/BChE-IN-1 is a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with blood-brain barrier permeability, exhibiting an IC50 value of 1.06 and 7.3 nM for hAChE and hBChE, respectively, and showin... |
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T61408 |
BChE-IN-2
|
|
|
|
BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1] |
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T63091 |
BChE-IN-5
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|
|
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BChE-IN-5 is a potent and selective inhibitor of BChE (IC50: 2.8 nM) and has a higher inhibitory effect on hBChE than hAChE. BChE-IN-5 has potential for use in Alzheimer's disease research. |
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T82915 |
BChE-IN-21
|
|
|
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BChE-IN-21, a potent inhibitor of butyrylcholinesterase (BChE), exhibits an inhibition constant (IC50) of 0.14 ± 0.02 μM, indicating promise for research in Alzheimer's disease [1]. |
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T74812 |
HBChE-IN-1
|
|
|
|
hBChE-IN-1 (compound 4), a quinolizidinyl derivative, effectively inhibits human Butyrylcholinesterase (hBChE) with an IC50 value of 7 nM, demonstrating high selectivity against human Acetylcholinesterase (hAChE). It als... |
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T60691 |
AChE/BChE/BACE-1-IN-2
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AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val... |
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T60529 |
AChE/BChE-IN-3
|
|
|
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AChE/BChE-IN-3 (BMC-1) is an AChE and BChE dual inhibitor with IC 50 values of 6.08 μM for electric eel AChE (elAChE) and 0.383 μM for equine serum BChE (eqBChE), respectively [1]. |
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T60721 |
AChE/BChE-IN-5
|
|
|
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AChE/BChE-IN-5 (BMC-16) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-5 for human AChE (hAChE) and human BChE (hBChE) are 266 nM and 10.6 nM , respectively [1]. |
|
T61785 |
BChE-IN-6
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|
|
|
BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serve... |
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T61342 |
BChE-IN-13
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|
|
|
BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates ... |
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T79966 |
AChE/BChE-IN-14
|
|
|
|
AChE/BChE-IN-14 (compound 13), a benzylisoquinoline alkaloid extracted from Fissistigma polyanthum roots, demonstrates inhibitory effects on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), coupled with... |
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T79548 |
AChE/BChE-IN-13
|
|
|
|
AChE/BChE-IN-13 (compound 5j) serves as a potent dual inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting half-maximal inhibitory concentrations (IC50) of 20.89 μM for AChE and 17.3... |
|
T79342 |
BChE-IN-17
|
|
|
|
BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 10.5 nM for equine BChE (eqBChE) and 32.5 nM for human... |
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T61206 |
AChE/BChE/BACE-1-IN-1
|
|
|
|
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ... |
|
T77509 |
HBChE-IN-2
|
|
|
|
|
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T61994 |
AChE/BChE-IN-8
|
|
|
|
AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor. AChE/BChE-IN-8 shows Ki of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE... |
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T72454 |
AChE/BChE/MAO-B-IN-4
|
|
|
|
AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, serves as a potent inhibitor for both monoamine oxidase B (MAO-B) and acetylcholinesterase/butyrylcholinesterase (AChE/BChE) enzymes. It exhibits a strong inhibitory effec... |
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T72453 |
AChE/BChE/MAO-B-IN-3
|
|
|
|
AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, serves as a potent inhibitor of human monoamine oxidase B (MAO-B) with an IC50 of 0.0359 μM, demonstrating significant inhibitory effects on acetylcholinesterase (AChE) an... |
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T60720 |
AChE/BChE-IN-4
|
|
|
|
AChE/BChE-IN-4 (BMC-3) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-4 for human AChE (hAChE) and human BChE (hBChE) are 792 nM and 2.2 nM, respectively[1]. |
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T82916 |
BChE-IN-20
|
|
|
|
BChE-IN-20 (compound 7c) is a potent, selective inhibitor of BChE, demonstrating IC50 values of 105 nM for eqBChE and 2.3 nM for hBChE. It also inhibits P glycoprotein with an IC50 of 0.27 μM. As a promising template, BC... |
|
T61050 |
BChE-IN-7
|
|
|
|
BChE-IN-7 (compound 13) is a potent, selective, and reversible inhibitor of AChE and BChE. The IC50 value of BChE-IN-7 for BChE is 0.06 μM. BChE-IN-7 is able to cross the blood-brain barrier and protect neuronal-like cel... |
|
T61397 |
AChE/BChE-IN-9
|
|
|
|
AChE/BChE-IN-9 (Compound 7a) is a potent orally active inhibitor of AChE and BChE, with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. It also demonstrates effective antioxidant activity, wit... |
|
T60983 |
BChE-IN-14
|
|
|
|
BChE-IN-14 (compound 19c) can restore cognitive impairment in vivo that can be used in the Alzheimer’s disease research. BChE-IN-14 has primary cell safety and good blood brain barrier permeability. BChE-IN-14 is a selec... |
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T78828 |
AChE/BChE-IN-15
|
|
|
|
AChE/BChE-IN-15 (Compound 6d) serves as an inhibitor for both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), presenting inhibition constants (IC50) of 20 nM for AChE and 220 nM for BChE. It interacts with ... |
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T79692 |
BChE-IN-19
|
|
|
|
BChE-IN-19 (Compound 7b), a para-substituted indone derivative, exhibits potent inhibitory activity against butyryl cholinesterase (BChE) with an IC50 value of 0.04 μM. It enhances cholinergic neurotransmission and has p... |
|
T62565 |
BChE-IN-9
|
|
|
|
BChE-IN-9 (Azepano-11-deoxo-glycyrrhetol) is a hybrid BChE inhibitor (Ki: 0.21 μM). |
|
T77658 |
BChE/HDAC6-IN-2
|
|
|
|
|
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T11814 |
Lamivudine 13C,15N2
|
|
Others
|
|
Lamivudine 13C,15N2, an impurity of Lamivudine (BCH-189), functions as an inhibitor of both HIV-1/2 reverse transcriptase and hepatitis B virus reverse transcriptase, classifying it as a nucleoside reverse transcriptase ... |
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T61427 |
Lamivudine salicylate
|
|
|
|
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demon... |
