|
T23587 |
8-CSC
|
8 CSC,CSC |
|
|
8-CSC is a dual agent endowed with good hMAO-B inhibitory activity (Ki: 235 nM in baboon liver mitochondria) and A2A affinity (Ki: 36 nM in rat brain striatal membranes receptor). |
|
T73995 |
EGFR/CSC-IN-1
|
|
EGFR
|
|
EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential applications in triple-negative breast cancer research. |
|
T0365 |
Thioridazine hydrochloride
|
Mellaril,Aldazine |
Apoptosis
,
Potassium Channel
,
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Autophagy
|
|
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. |
|
T33519 |
MTOB
|
α-keto-γ-Methylthiobutyric acid,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid |
Others
|
|
MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, lea... |
|
T10904 |
CWP232228
|
|
Wnt/beta-catenin
|
|
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... |
|
T20974 |
IR-780 Iodide
|
IR 780 iodide |
Others
|
|
IR-780 Iodide (IR 780 iodide), a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity. |
|
T24879 |
Thioxodihydroquinazolinone-19
|
Thioxodihydroquinazolinone19 |
|
|
In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisp... |
|
T61885 |
Sulconazole
|
|
|
|
Sulconazole is an imidazole compound with effective antifungal effect. Sulconazole vs. NF- κ B/IL-8 signal pathway has blocking effect and inhibiting effect on the formation of cancer stem cells (CSC). Sulconazole has in... |
|
T71998 |
673-A
|
|
|
|
673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupli... |
|
T74092 |
Cyanine5 alkyne
|
|
|
|
Cyanine5 alkyne (Alkyne-Cy5), a fluorescent dye, labels azide proteins for analyzing post-translational modifications, such as glycosylation. Additionally, it serves as a mitochondrial OXPHOS inhibitor, curtailing the pr... |
|
T21762 |
LDN-211904
|
|
|
|
LDN-211904 oxalate (compound 32), a potent and selective EphB3 inhibitor, demonstrates an IC50 of 0.079 μM and shows good metabolic stability in mouse liver microsomes. When combined with cetuximab, it may effectively in... |
|
T39792 |
AMPC
|
|
|
|
AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone an... |
|
T4134L |
OTS514
|
OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514 |
Apoptosis
,
TOPK
|
|
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen... |
|
T72658 |
CRIPGBM chloride
|
|
|
|
cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-... |
