Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 53,500 |
5 mg | 在庫あり | ¥ 114,000 |
10 mg | 在庫あり | ¥ 166,000 |
25 mg | 在庫あり | ¥ 259,500 |
50 mg | 在庫あり | ¥ 349,000 |
100 mg | 在庫あり | ¥ 454,500 |
説明 | CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and liver cancer stem cells (CSC) without toxicity. |
In vitro | CWP232228 (0.01-100 μM; 48 hours) inhibited cell proliferation, and IC50 values in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines were 2 and 0.8 μM, respectively. CWP232228 (0.01-10 μM; 48 hours) inhibited cell proliferation in Hep3B, Huh7 and HepG2 cells with IC50 of 2.566, 2.630 and 2.596 μM, respectively. |
In vivo | CWP232228 (100 mg/kg, administered i.p.; daily; mice with 4T1 cell tumors for 21 days; mice with MDA-MB-435 cell tumors for 60 days) resulted in a significant reduction in tumor volume. |
分子量 | 673.66 |
分子式 | C33H36N7O7P |
CAS No. | 1144044-02-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 60 mg/mL (83.61 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CWP232228 1144044-02-9 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin CWP 232228 Beta catenin Wnt CWP-232228 Breast β-catenin Inhibitor cells signaling stem Cancer inhibit liver inhibitor