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T1787 |
Levobupivacaine
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Sodium Channel
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Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... |
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T22394 |
Paritaprevir
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ABT450,ABT-450,Veruprevir |
HCV Protease
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Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively. |
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T6566 |
Levobupivacaine hydrochloride
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Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel
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Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic... |
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T22003 |
2,3-dihydrothieno-Thiadiazole Carboxylate
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P450
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2,3-dihydrothieno-Thiadiazole Carboxylate is a CYP450 (CYP2E1 and CYP2B4) inhibitor. |
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T20373 |
1-Phenylpyrrole
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NSC16581,NSC-16581,NSC 16581 |
Others
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1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver. |
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T4983 |
Isoetharine mesylate salt
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Isoetarine mesilate |
Others
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Adrenergic Receptor
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Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression. |
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T37826 |
CAY10462
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CAY10462,CTK8E8405 |
P450
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CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less potent for 1A, 1C, and 3A CYP450 enzymes. |
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T1540 |
Doxepin hydrochloride
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Toruan,Doxepin HCl,Aponal,Novoxapin |
P450
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Dopamine Receptor
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5-HT Receptor
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Adrenergic Receptor
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AChR
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Norepinephrine
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Histamine Receptor
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Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap... |
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T4567 |
Sulfaphenazole
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Plisulfan,Raziosulfa,Depocid,Depotsulfonamide |
P450
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Antibacterial
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Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1... |
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T11556 |
HET0016
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Others
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HET0016 is a potent and selective 20-HETE synthase inhibitor (IC50s: 17.7 nM, 12.1 nM, and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis). HET0016 also is a selective CYP450 inhibitor, w... |
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T14021 |
20-HETE
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20-hydroxy Arachidonic Acid |
Others
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20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... |
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T11847L |
Liarozole
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R75251 dihydrochloride |
P450
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Retinoid Receptor
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Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... |
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T14186 |
17-ODYA
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Alkynyl Stearic Acid |
Others
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PROTAC Linker
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17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
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T36696 |
DMBA
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7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... |
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T14841 |
BVT948
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Phosphatase
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P450
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Histone Methyltransferase
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BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A). |
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T16704 |
Quilseconazole
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VT-1129 |
Others
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Quilseconazole is an effective, orally active fungal Cyp51 inhibitor. it also binds tightly to cryptococcal CYP51 but weakly inhibits humans CYP450 enzymes. |
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T11088 |
Doxepin D3 Hydrochloride
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Histamine Receptor
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Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, signi... |
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T78154 |
CS640
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CS640 is a selective calmodulin-dependent kinase inhibitor, targeting multiple isoforms, namely CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4, and MLK3, with respective IC50 values of 0.08, 0.03, 0.001, 0.001, 11.... |
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T37181 |
Avanafil metabolite M4
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Avanafil metabolite M4 |
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Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanaf... |
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T37234 |
(±)14(15)-EpETE
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de... |
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T25716L |
Liarozole HCl
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R75251,Liarozole hydrochloride,R 75251,R-75251 |
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Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an incr... |
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T37235 |
(±)16(17)-EpDPA
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(±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA |
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de... |
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T37180 |
Avanafil metabolite M16
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Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites ava... |
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T36145 |
12(R)-HETE
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Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predomina... |
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T35847 |
16(R)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation... |
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T37238 |
(±)19(20)-EpDPA
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de... |
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T11847 |
Liarozole dihydrochloride
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R75251 dihydrochloride |
Others
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Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lya... |
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T35850 |
19(S)-HETE
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19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o... |
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T35848 |
16(S)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation... |
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T35523 |
(±)17-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereos... |
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T35467 |
(±)18-HETE
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(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasod... |
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T37708 |
17(R)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17... |
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T37788 |
Resorufin benzyl ether
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Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compoun... |
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T35849 |
17(S)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-... |
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T73898 |
Paritaprevir dihydrate
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Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ... |
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T37241 |
(±)4(5)-EpDPA methyl ester
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(±)4(5)-EpDPA methyl ester is a derivative of (±)4(5)-EpDPA which is stable enough to ship and handle routinely. The active free acid can be regenerated from the methyl ester by careful base hydrolysis. (±)4(5)EpDPA is a... |
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T36216 |
19(R)-HETE
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19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o... |
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T37228 |
(±)8(9)-EpETE
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Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle b... |
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T35465 |
(±)16-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon ... |
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T35715 |
N-desmethyl Eletriptan
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N-desmethyl Eletriptan is a metabolite of eletriptan .1It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes.
1.Evans, D.C., O’Connor, D., Lake, B.G., et al.Eletript... |
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T35494 |
(±)11(12)-EET
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(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C... |
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T79568 |
NPD-2975
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Parasite
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NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibrobl... |
