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Search Results for " CYP450 "

ターゲット

41

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3

天然化合物

カタログ番号 製品名 別名 ターゲット
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T22394 Paritaprevir ABT450,ABT-450,Veruprevir HCV Protease
Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.
T6566 Levobupivacaine hydrochloride Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride Sodium Channel
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic...
T22003 2,3-dihydrothieno-Thiadiazole Carboxylate P450
2,3-dihydrothieno-Thiadiazole Carboxylate is a CYP450 (CYP2E1 and CYP2B4) inhibitor.
T20373 1-Phenylpyrrole NSC16581,NSC-16581,NSC 16581 Others
1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver.
T37826 CAY10462 CAY10462,CTK8E8405 P450
CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less potent for 1A, 1C, and 3A CYP450 enzymes.
T4983 Isoetharine mesylate salt Isoetarine mesilate Others , Adrenergic Receptor
Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.
T1540 Doxepin hydrochloride Toruan,Doxepin HCl,Aponal,Novoxapin P450 , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap...
T11556 HET0016 Others
HET0016 is a potent and selective 20-HETE synthase inhibitor (IC50s: 17.7 nM, 12.1 nM, and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis). HET0016 also is a selective CYP450 inhibitor, w...
T4567 Sulfaphenazole Plisulfan,Raziosulfa,Depocid,Depotsulfonamide P450 , Antibacterial
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...
T14021 20-HETE 20-hydroxy Arachidonic Acid Others
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ...
T11847L Liarozole R75251 dihydrochloride P450 , Retinoid Receptor
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...
T14186 17-ODYA Alkynyl Stearic Acid Others , PROTAC Linker
17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
T14841 BVT948 Phosphatase , P450 , Histone Methyltransferase
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
T16704 Quilseconazole VT-1129 Others
Quilseconazole is an effective, orally active fungal Cyp51 inhibitor. it also binds tightly to cryptococcal CYP51 but weakly inhibits humans CYP450 enzymes.
T11088 Doxepin D3 Hydrochloride Histamine Receptor
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, signi...
T78154 CS640
CS640 is a selective calmodulin-dependent kinase inhibitor, targeting multiple isoforms, namely CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4, and MLK3, with respective IC50 values of 0.08, 0.03, 0.001, 0.001, 11....
T37234 (±)14(15)-EpETE
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T37181 Avanafil metabolite M4 Avanafil metabolite M4
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanaf...
T25716L Liarozole HCl R75251,Liarozole hydrochloride,R 75251,R-75251
Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an incr...
T37235 (±)16(17)-EpDPA (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T36145 12(R)-HETE
Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predomina...
T37180 Avanafil metabolite M16
Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites ava...
T35847 16(R)-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation...
T37238 (±)19(20)-EpDPA
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-de...
T35523 (±)17-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereos...
T35467 (±)18-HETE
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasod...
T35850 19(S)-HETE
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o...
T11847 Liarozole dihydrochloride R75251 dihydrochloride Others
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lya...
T35849 17(S)-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-...
T35848 16(S)-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation...
T37708 17(R)-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17...
T36216 19(R)-HETE
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o...
T37788 Resorufin benzyl ether
Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compoun...
T73898 Paritaprevir dihydrate
Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ...
T37241 (±)4(5)-EpDPA methyl ester
(±)4(5)-EpDPA methyl ester is a derivative of (±)4(5)-EpDPA which is stable enough to ship and handle routinely. The active free acid can be regenerated from the methyl ester by careful base hydrolysis. (±)4(5)EpDPA is a...
T37228 (±)8(9)-EpETE
Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle b...
T35465 (±)16-HETE
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon ...
T35715 N-desmethyl Eletriptan
N-desmethyl Eletriptan is a metabolite of eletriptan .1It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. 1.Evans, D.C., O’Connor, D., Lake, B.G., et al.Eletript...
T35494 (±)11(12)-EET
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C...
T79568 NPD-2975 Parasite
NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibrobl...

Compounds

Levobupivacaine
T1787
Synonym:
Target: Sodium Channel
Paritaprevir
T22394
Synonym: ABT450,ABT-450,Veruprevir
Target: HCV Protease
Levobupivacaine hydrochloride
T6566
Synonym: Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride
Target: Sodium Channel
2,3-dihydrothieno-Thiadiazole Carboxylate
T22003
Synonym:
Target: P450
1-Phenylpyrrole
T20373
Synonym: NSC16581,NSC-16581,NSC 16581
Target: Others
CAY10462
T37826
Synonym: CAY10462,CTK8E8405
Target: P450
Isoetharine mesylate salt
T4983
Synonym: Isoetarine mesilate
Target: Others, Adrenergic Receptor
Doxepin hydrochloride
T1540
Synonym: Toruan,Doxepin HCl,Aponal,Novoxapin
Target: P450, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor
HET0016
T11556
Synonym:
Target: Others
Sulfaphenazole
T4567
Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide
Target: P450, Antibacterial
20-HETE
T14021
Synonym: 20-hydroxy Arachidonic Acid
Target: Others
Liarozole
T11847L
Synonym: R75251 dihydrochloride
Target: P450, Retinoid Receptor
17-ODYA
T14186
Synonym: Alkynyl Stearic Acid
Target: Others, PROTAC Linker
BVT948
T14841
Synonym:
Target: Phosphatase, P450, Histone Methyltransferase
Quilseconazole
T16704
Synonym: VT-1129
Target: Others
Doxepin D3 Hydrochloride
T11088
Synonym:
Target: Histamine Receptor
CS640
T78154
Synonym:
Target:
(±)14(15)-EpETE
T37234
Synonym:
Target:
Avanafil metabolite M4
T37181
Synonym: Avanafil metabolite M4
Target:
Liarozole HCl
T25716L
Synonym: R75251,Liarozole hydrochloride,R 75251,R-75251
Target:
(±)16(17)-EpDPA
T37235
Synonym: (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
Target:
12(R)-HETE
T36145
Synonym:
Target:
Avanafil metabolite M16
T37180
Synonym:
Target:
16(R)-HETE
T35847
Synonym:
Target:
(±)19(20)-EpDPA
T37238
Synonym:
Target:
(±)17-HETE
T35523
Synonym:
Target:
(±)18-HETE
T35467
Synonym:
Target:
19(S)-HETE
T35850
Synonym:
Target:
Liarozole dihydrochloride
T11847
Synonym: R75251 dihydrochloride
Target: Others
17(S)-HETE
T35849
Synonym:
Target:
16(S)-HETE
T35848
Synonym:
Target:
17(R)-HETE
T37708
Synonym:
Target:
19(R)-HETE
T36216
Synonym:
Target:
Resorufin benzyl ether
T37788
Synonym:
Target:
Paritaprevir dihydrate
T73898
Synonym:
Target:
(±)4(5)-EpDPA methyl ester
T37241
Synonym:
Target:
(±)8(9)-EpETE
T37228
Synonym:
Target:
(±)16-HETE
T35465
Synonym:
Target:
N-desmethyl Eletriptan
T35715
Synonym:
Target:
(±)11(12)-EET
T35494
Synonym:
Target:
NPD-2975
T79568
Synonym:
Target: Parasite
カタログ番号 製品名 別名 ターゲット
T2S0663 Humantenmine P450
1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
T3696 Polygalaxanthone III Others , P450
Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
T5786 TETRAHYDROPIPERINE Cosmoperine P450 , TRP/TRPV Channel
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.