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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T1418	Bucladesine sodium	dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt	PKA , PDE
	Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-in...		PKA , PDE
T5315	TCA1	TCA-1,TCA 1	Antibacterial , Antibiotic
	TCA1 (TCA 1) is a small molecule with activity against drug-resistant and persistent tuberculosis.		Antibacterial , Antibiotic
T10601	BRCA1-IN-2		Others
	BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.		Others
T22967	MEDICA16	MEDICA 16	GPR , Others , ATP Citrate Lyase
	Free fatty acid 1 (FFA1/GPR40) receptor agonist		GPR , Others , ATP Citrate Lyase
T10600	BRCA1-IN-1		Others
	BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).		Others
T72195	KCa1.1 channel activator-2		Others
	KCa1.1 channel activator-2, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels. This compound demonstrates significant myorelaxant activity.		Others
T40296	MCA17-1	MCA17-1	Others
	MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.		Others
T72194	KCa1.1 channel activator-1		Others
	KCa1.1 Channel Activator-1, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels while also blocking CaV1.2 channels. Additionally, it demonstrates weak myorelaxant activity.		Others
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
TP1895L1	KYL acetate(676657-00-4 free base)		Ephrin Receptor
	KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...		Ephrin Receptor
TP1945L1	Pep2m, myristoylated acetate	Pep2m, myristoylated acetate(1423381-07-0 free base)	PKC
	Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei...		PKC
T0782	Benzthiazide	Aquatag,Lemazide,Dihydrex	Carbonic Anhydrase
	Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ...		Carbonic Anhydrase
TP1895	KYL peptide	KYL
	KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...
T76590	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
	(D(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, serving as an oxytocin receptor antagonist, effectively nullifies the augmentation of inhibitory postsynaptic currents in CA1 pyramidal neurons by oxytocin [1].
T73099	Etbicyphat	Trimethylopropane phosphate	Others
	Etbicyphat (Trimethylopropane phosphate), a potent competitive antagonist of GABA(A) receptors, binds to GABA(A)-benzodiazepine receptors and induces epileptiform activities in hippocampal CA1 neurons.		Others
T37208	NAP-1		Others
	NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in ...		Others
T24919	UBP714	UBP 714,UBP-714	Others
	UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent...		Others
T28653	S-8510 free base	SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510	Others
	S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ame...		Others
TP1945	Pep2m, myristoylated
	Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates ...
T70063	GYKI 52466 HCl		Others
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i...		Others
T37388	Afizagabar		Others
	Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy...		Others

Compounds

Bucladesine sodium

T1418

Synonym: dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt

Target: Antibacterial, Antibiotic

Target: GPR, Others, ATP Citrate Lyase

KCa1.1 channel activator-2

KCa1.1 channel activator-1

KYL acetate(676657-00-4 free base)

TP1895L1

Synonym:

Target: Ephrin Receptor

Pep2m, myristoylated acetate

TP1945L1

Synonym: Pep2m, myristoylated acetate(1423381-07-0 free base)

Target: PKC

Benzthiazide

T0782

Synonym: Aquatag,Lemazide,Dihydrex

Target: Carbonic Anhydrase

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin

Synonym: Trimethylopropane phosphate

Synonym: UBP 714,UBP-714

Target: Others

S-8510 free base

T28653

Synonym: SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510

カタログ番号	製品名	別名	ターゲット
T9143	D-Isoleucine	(2R,3R)-2-Amino-3-methylpentanoic acid,(R)-Isoleucine	Others
	D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine.		Others
T6S2115	Ginkgolide J	BN 52024,7-beta-Hydroxyginkgolide A	PDE
	Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.		PDE
TN1601	Effusol		Caspase
	Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampa...		Caspase
T14011	2-Arachidonoylglycerol		Cannabinoid Receptor , Endogenous Metabolite
			Cannabinoid Receptor , Endogenous Metabolite
T36448	(E)-Ajoene		Others
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fu...		Others

天然物製品

D-Isoleucine

T9143

Synonym: (2R,3R)-2-Amino-3-methylpentanoic acid,(R)-Isoleucine

Target: Others

Ginkgolide J

T6S2115

Synonym: BN 52024,7-beta-Hydroxyginkgolide A

2-Arachidonoylglycerol

T14011

Synonym:

Target: Cannabinoid Receptor, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03258	Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the acce...
TMPJ-00731	Carbonic Anhydrase 1 Protein, Human, Recombinant (His)	Human	E. coli
	Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 p...
TMPK-01365	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.98 kDa and the accession number is Q8WXI7.
TMPH-01564	ICA1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in neurotransmitter secretion.
TMPK-01366	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPK-01359	CA125/MUC16 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPJ-01432	CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293 Cells
	MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by t...
TMPH-02936	FUCA1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. FUCA1 Protein, Mouse, Recombinant (His & SUMO) i...
TMPY-03282	FUCA1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in FUCA1 gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal stor...
TMPY-06614	CA125/MUC16 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1.
TMPY-01734	CA13 Protein, Human, Recombinant (His)	Human	E. coli
	The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bi...
TMPK-01394	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His)	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 76.17 kDa and the accession number is Q8WXI7.