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TP2331 |
Leishmania peptide 183
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Peptide 183,p183,Leishmania |
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Leishmania peptide 183 is an antigen. |
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T12909 |
SID 26681509
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Cysteine Protease
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Parasite
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T62330 |
Antileishmanial agent-12
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Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent with antibacterial activity against Leishmania brazilensis (IC50: 14.9 μM), Leishmania infantum (IC50: 21.3 μM) and T. cruzi (IC50. 9.3 μM). 9.3 μ... |
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T63281 |
Antileishmanial agent-11
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Antileishmanial agent-11 is a potent antileishmanial agent that acts on Leishmania brazilensis (IC50: 28.3 μM), Leishmania infantum (IC50: 24.8 μM) and T. cruzi (IC50: 13.0 μM) with outstanding antiprotozoal effect. |
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T61391 |
Antileishmanial agent-3
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Antileishmanial agent-3 (Compound 13) effectively inhibits the growth of Leishmania major [1]. |
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T78963 |
Antileishmanial agent-16
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Parasite
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Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety p... |
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T61710 |
Antileishmanial agent-7
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Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1]. |
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T61416 |
Antileishmanial agent-9
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Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity i... |
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T62574 |
Antileishmanial agent-6
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Antileishmanial agent-6 is a potent anti-leishmanial agent with anti-leishmanial activity (IC50: 0.54 μM) and cytotoxicity (IC50: 10.2 μM) against Leishmania donovani and L-6. |
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T78680 |
Antileishmanial agent-14
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Parasite
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Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by L. donovani amastigotes (IC 50 = 11.1 μM) [1]. |
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T60638 |
Antileishmanial agent-8
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Antileishmanial agent-8 (compound 18) shows potent and selective activity against Leishmania donovani ( L. donovani ) (IC50 = 5.64 μM) with relatively low cytotoxicity in L-6 cells (IC 50 =73.9 μM) [1]. |
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T79471 |
Antileishmanial agent-20
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Parasite
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Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1]. |
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T79390 |
Antileishmanial agent-23
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Parasite
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Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypan... |
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T72260 |
Antileishmanial agent-13
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Antileishmanial agent-13, a quinoline-isatin hybrid, functions as an antileishmanial agent targeting the L. Major Leishmania strain through an anti-folate mechanism. This compound exhibits potent inhibition of both the p... |
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T79632 |
Antileishmanial agent-21
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Parasite
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Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin.... |
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T79449 |
Antileishmanial agent-19
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Parasite
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Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and d... |
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T79633 |
Antileishmanial agent-22
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Parasite
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Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppres... |
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T61199 |
Antileishmanial agent-2
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Antileishmanial agent-2 demonstrates potent submicromolar antileishmanial activity (IC50 = 0.29 μM) and a remarkable selectivity index against mammalian cells. |
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T61560 |
Antileishmanial agent-5
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Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1]. |
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T78964 |
Antileishmanial agent-17
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Parasite
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Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine redu... |
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T61100 |
Antileishmanial agent-4
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Antileishmanial agent-4, a ribonucleoside analogue, functions as an antileishmanial agent [1]. |
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T40117 |
Antileishmanial agent-1
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Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM). |
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T62210 |
Antileishmanial agent-10
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Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent. |
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T83045 |
Antileishmanial agent-25
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Parasite
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Antileishmanial agent-25 (compound 24) exhibits selective activity against intracellular amastigotes, demonstrating an inhibitory concentration (IC50) of 6.63 μM [1]. |
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T78962 |
Antileishmanial agent-15
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Parasite
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Antileishmanial agent-15 (compound 13c) exhibits potent activity against L. major promastigotes and amastigotes, demonstrating IC50 values of 0.78 μM for promastigotes and 0.99 μM for amastigotes, while also showing cyto... |
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T79419 |
Antileishmanial agent-24
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Parasite
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Antileishmanial agent-24 (compound 33) exhibits antileishmanial activity, demonstrating an inhibitory concentration 50 (IC50) value of 5.39 μM against amastigotes [1]. |
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T60531 |
2'-C-Methyladenosine
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HCV Protease
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2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis.2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed ... |
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T23132 |
Pentamidine dihydrochloride
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MP-601205 dihydrochloride |
Phosphatase
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Antibacterial
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Antibiotic
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Parasite
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Antifungal
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Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi... |
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T16546 |
PK 11195
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RP 52028 |
Others
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PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively). |
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T60092 |
CHEMBL1276927
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N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide,N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide |
Antibacterial
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Parasite
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CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) shows antibacterial and antiparasitic activities against Chlamydia pneumoniae and Leishmania donovani. |
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T1654 |
Pentamidine isethionate
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Pentamidine isethionate salt,Pentamidine diisethionate |
Phosphatase
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Antibacterial
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Antibiotic
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Parasite
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Antifungal
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Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent. |
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T39746 |
DNDI-6148
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Parasite
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DNDI-6148 has anti-experimental cutaneous leishmaniasis activity and can be used to study visceral leishmaniasis by inhibiting Leishmania protozoa cleavage and polyadenylation-specific factor (CPSF3) endonuclease. |
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T9858 |
5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
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Parasite
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Antileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM. |
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T2112 |
Fexinidazole
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HOE 239 |
Others
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Parasite
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Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica... |
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T15095 |
Dehydroemetine
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Others
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Parasite
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Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania... |
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T68109 |
Moxipraquine
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Antibiotic
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Moxipraquine is a novel 8-aminoquinolone compound with anti-infective activity against Trypanosoma cruzi. Moxipraquine effectively inhibited parasitemia but did not eradicate infections in mice or guinea pigs. Moxipraqui... |
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T15546 |
ICA
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N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine |
Potassium Channel
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Parasite
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ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM). |
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T23133 |
Pentamidine
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Phosphatase
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Antibacterial
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Antibiotic
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Parasite
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Antifungal
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Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. |
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T15110 |
DHQZ 36
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Others
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DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM). |
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T69891 |
CGP 40215
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CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes |
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T20303 |
Dibenzalacetone
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AI3-00896,AI3 00896,AI300896 |
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Dibenzylideneacetone is a synthetic curcumin analog. It leads to apoptotic cell death in Leishmania donovani. |
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T69511 |
Diospyrin
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Diospyrin is a plant product that has significant inhibitory effect on the growth of Leishmania donovani promastigotes. |
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T61364 |
LmCPB-IN-1
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LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1]. |
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T72925 |
Naloxonazine
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Naloxonazine, a potent, selective opiate mu-1 (μ1) antagonist, also influences leishmania through the modulation of host coding function. |
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T40652 |
Meclizine
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Meclozine |
Histamine Receptor
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Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
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T83025 |
Antiparasitic agent-19
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Antiparasitic Agent-19 (Compound 40) is a broad-spectrum antiparasitic with minimal toxicity to Trypanosoma brucei, Leishmania infantum, and Trypanosoma cruzi [1]. |
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T61245 |
Antiparasitic agent-7
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Antiparasitic agent-7 (compound 5d) displays specific antiparasitic activity against Leishmania infantum (L. infantum), exhibiting an IC50 value of 2.85 μM. Additionally, Antiparasitic agent-7 demonstrates cytotoxicity a... |
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T63831 |
SID 26681509 quarterhydrate
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SID 26681509 quarterhydrate is a reversible, potent, selective, competitive inhibitor of human cathepsin L (IC50: 56 nM). SID 26681509 inhibits in vitro propagation of Plasmodium falciparum (IC50: 15.4 μM) and inhibits L... |
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T61641 |
Antiparasitic agent-5
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Antiparasitic agent-5 (compound 8h) exhibits potent selectivity as an antiparasitic agent against Leishmania infantum (L. infantum), with an IC50 value of 2.50 μM. Additionally, this compound displays cytotoxic effects o... |
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T80648 |
Eugenitin
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Parasite
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Eugenitin, a polyketide from Mycoleptodiscus indicus, exhibits inhibitory activity against Leishmania major with an LD50 of 39.9 μM and demonstrates low cytotoxicity (IC50 >131 μM) in various human cancer cell lines [1]. |
