|
T6440 |
CGP 57380
|
MNK1 Inhibitor |
Apoptosis
,
MNK
|
|
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. |
|
T62686 |
MNK1/2-IN-6
|
|
|
|
MNK1/2-IN-6 is a potent and selective inhibitor of MNK1 (IC50: 2.3 nM), MNK2 (IC50: 3.4 nM), and MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner. |
|
T60733 |
MNK1/2-IN-5
|
|
|
|
MNK1/2-IN-5 is a potent and selective inhibitor of MNK1/2. |
|
T9034 |
MK2-IN-3
|
MK2 Inhibitor III |
MAPK
|
|
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis |
|
T4424 |
SLV-2436
|
SEL-201,SLV 2436,SEL201-88 |
MNK
|
|
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM). |
|
T15250 |
ETC-206
|
|
MNK
|
|
ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM). |
|
T60681 |
DS12881479
|
|
MNK
|
|
DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1]. |
|
T3468 |
Tomivosertib
|
eFT508 |
MNK
,
PD-1/PD-L1
|
|
Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM. |
|
T73582 |
EB1
|
|
MNK
|
|
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits t... |
|
T6092 |
Sapitinib
|
AZD-8931 |
EGFR
|
|
Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the E... |
|
T60657 |
(R)-STU104
|
|
TNF
,
MAPK
|
|
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of... |
|
T38960 |
QL-X-138
|
|
Virus Protease
,
MNK
,
BTK
|
|
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, MNK1 and MNK2 kinases are 9.4 nM, 107.4 nM and 26 nM, respe... |
|
T38960L |
QL-X-138 HCl
|
QL-X-138 HCl（1469988-63-3 Free base） |
MNK
,
BTK
|
|
QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-1... |
|
T72752 |
MNK inhibitor 9
|
|
|
|
MNK Inhibitor 9 is a potent, selective inhibitor of MNK1/2, demonstrating IC50 values of 0.003 µM for both MNK1 and MNK2. It exhibits good cell permeability, making it suitable for tumor-related research. |
|
T41165 |
ETP 45835 dihydrochloride
|
|
|
|
ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein Ki nases, including those upstream of Mnk1/2. |
|
T22771 |
ETP 45835 dihydrochloride (794510-70-6 free base)
|
ETP 45835 dihydrochloride |
Others
|
|
Mnk1/2 inhibitor |
|
T70124 |
Tomivosertib HCl
|
|
|
|
Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory pr... |
|
T12058 |
MK2-IN-3 hydrate
|
MK-2 Inhibitor III |
ERK
,
MAPK
,
MNK
|
|
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM) |
