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カタログ番号 | 製品名 | 別名 | ターゲット |
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T37173 | MPro Inhibitor 11a | ||
MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-i... | |||
T38175 | MPro N3 | ||
Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibit... | |||
T38174 | Mpro inhibitor N3 hemihydrate | ||
Mpro inhibitor N3 hemihydrate is a potent antagonist of the SARS-CoV-2 main protease (Mpro), demonstrating an EC50 of 16.77 μM against SARS-CoV-2. It exhibits specific inhibition of Mpro in a range of coronaviruses, incl... | |||
T63098 | SARS-CoV-2 Mpro-IN-2 | ||
SARS-CoV-2 MPro-IN-2 is a selective, low cytotoxic, non-covalent Mpro inhibitor with an IC50 value of 0.40 μM. SARS-CoV-2 Mpro-IN-2 showed good anti-SARS-CoV-2 effect with EC50 value of 1.1 μM. SARS-CoV-2 Mpro-IN-2 can b... | |||
T37174 | SARS-CoV MPro-IN-1 | ||
MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-in... | |||
T69545 | Mpro 61 | ||
Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease. | |||
T62991 | Mpro/PLpro-IN-1 | ||
Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease.Mpro/PLpro-IN-1 is also a potent inhibitor of Mpro/PLpro, with micromolar inhibition of M pro (IC50:1.72 μM) and submicromolar inhibition of... | |||
T60686 | SARS-CoV-2 Mpro-IN-1 | ||
SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible SARS-CoV-2 main protease (Mpro) inhibitor (IC 50 = 116 nM) [1]. | |||
T72451 | SARS-CoV-2 Mpro-IN-6 | ||
SARS-CoV-2 Mpro-IN-6 is a selective, covalent, and irreversible inhibitor of SARS-CoV-2 main protease (Mpro), exhibiting an inhibition concentration (IC50) of 0.18 μM. It does not inhibit human cathepsins B, F, K, and L ... | |||
T72447 | SARS-CoV-2 Mpro-IN-5 | ||
SARS-CoV-2 Mpro-IN-5 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL) with IC50 values of 1800 nM and 145 nM, respectively. This compound demonstrates antiviral activity by inhibiting SARS-CoV-2... | |||
T79515 | SARS-CoV-2 Mpro-IN-10 | SARS-CoV | |
SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in research focused on the SARS-CoV-2 virus [1]. | |||
T79455 | SARS-CoV-2 Mpro-IN-9 | SARS-CoV | |
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma... | |||
T81210 | SARS-CoV-2 Mpro-IN-12 | SARS-CoV | |
SARS-CoV-2 Mpro-IN-12 (compound D026) serves as an inhibitor of the main protease (Mpro) of SARS-CoV-2, exhibiting antiviral properties [1]. | |||
T79278 | SARS-CoV-2 Mpro-IN-7 | SARS-CoV | |
SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50) of 10 μM [1]. | |||
T79279 | SARS-CoV-2 Mpro-IN-8 | SARS-CoV | |
SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1]. | |||
T72446 | SARS-CoV-2 Mpro-IN-4 | ||
SARS-CoV-2 Mpro-IN-4 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL), exhibiting inhibition concentrations (IC50) of 900 nM and 60 nM, respectively. It demonstrates antiviral activity by effect... | |||
T72231 | SARS-CoV-2/MERS Mpro-IN-2 | ||
SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 µM, respectively. | |||
T72230 | SARS-CoV-2/MERS Mpro-IN-1 | ||
SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 µM, respectively. | |||
T1307 | Carmofur | HCFU | Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis |
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T1673 | Acamprosate calcium | calcium acetylhomotaurinate,N-Acetylhomotaurine Calcium,Alcomed,Sobriol,Campral EC,Calcium N-acetylhomotaurinate | GABA Receptor |
Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence. | |||
T68921 | Impromidine hydrochloride | Histamine Receptor | |
Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies. | |||
T0872L | Amprolium Hydrochloride | Amprovine,Amprolio,Amprolium HCl | Parasite |
Amprolium Hydrochloride (Amprolium HCl) is a coccidiostat that interferes with thiamine metabolism. | |||
T66151 | Dimethylethylammoniumpropane sulfonate | ||
Dimethylethylammoniumpropane sulfonate is a useful organic compound for research related to life sciences and the catalog number is T66151. | |||
T32725 | L-Flamprop-isopropyl | Effix,(+)-Flamprop-isopropyl | |
L-Flamprop-isopropyl is a bioactive chemical. | |||
T73059 | Acamprosate | ||
Acamprosate, an orally active prototypic neuromodulator, is utilized in the study and treatment of alcohol dependence and alcoholism. | |||
T24162 | Impromidine | Impromidina,Impromidinum | |
Impromidine is a highly potent and specific agonist of the histamine H2 receptor. | |||
T20594 | Flamprop-methyl | WL-29761,Suffix plus,WL 29761,WL29761,Super-Suffix,Lancer | |
Flamprop-methyl is a post-emergence herbicide, it is usually used on wild oats. | |||
T0872 | Amprolium | Others , Parasite | |
Amprolium is a veterinary coccidiostat that interferes with THIAMINE metabolism. | |||
T8419 | XP-59 | SARS-CoV | |
XP-59 is a potent the SARS-CoV Mpro inhibitor(Ki : 0.1 μM). | |||
T8688 | (Rac)-X77 | CPD77,MUN91789 | SARS-CoV |
(Rac)-X77 (MUN91789) is a potent SARS- CoV- 2 main protease inhibitor. | |||
T9574 | PF-07304814 | Lufotrelvir | |
Lufotrelvir (PF-07304814) is a phosphate prodrug of PF-00835231 which acts as a potent 3CL pro protease ( M pro ) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CL pro activity w... | |||
T12836 | SARS-CoV-2-IN-1 | Others | |
T79344 | CDD-1819 | SARS-CoV | |
CDD-1819, a non-covalent and non-peptide compound, serves as a potent SARS-CoV-2 Mpro inhibitor, exhibiting a K i value of 5 nM. It also effectively inhibits the Mpro variants ΔP168, A173V, and ΔP168/A173V [1]. | |||
T68384 | SCHEMBL12616233 | ||
SCHEMBL12616233 is a novel inhibitor of SARS-CoV-2 main protease (MPro). | |||
T79345 | CDD-1733 | SARS-CoV | |
CDD-1733 is a potent, non-covalent, and non-peptide inhibitor of the SARS-CoV-2 main protease (Mpro) with an inhibition constant (K i) of 12 nM. It effectively inhibits Mpro variants including ΔP168, A173V, and the combi... | |||
T73555 | SPR41 | ||
SPR41, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibits Ki values of 0.184 µM for SARS-CoV-2 Mpro, 0.252 µM for hCatL, and 14.4 µM for hCatB, demonstrating significant antiviral activity and cytotoxici... | |||
T80636 | SARS-CoV-2-IN-59 | SARS-CoV | |
SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule that inhibits SARS-CoV-2 by targeting its main protease (Mpro). It exhibits robust binding with Mpro residues (Met 165, Gln 166,... | |||
T73553 | SPR39 | ||
SPR39, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrates inhibitory Ki values of 0.252 µM for SARS-CoV-2 Mpro, and 3.38 and 7.88 µM for human Cathepsin L (hCatL) and human Cathepsin B (hCatB) respec... | |||
T78895 | TKB245 | SARS-CoV | |
TKB245 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), effectively inhibiting viral replication in VeroE6 cells [1]. | |||
T79884 | D-4-77 | SARS-CoV | |
D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting an IC 50 of 0.95 μM, and possesses antiviral activity with an EC 50 of 0.49 μM. Furthermore, it suppresses SARS-CoV-2 Mpro-induced antagonism of the host NF-κB ... | |||
T69508 | GRL-1720 | ||
GRL-1720 is a SARS-CoV-2 Protease inhibitor (IC50 = 320 nM). GRL-1720 contains an indoline which targets the SARS-CoV-2 main protease (Mpro) | |||
T69572 | UAWJ248 | ||
UAWJ248 is a SARS-CoV-2 Protease inhibitor. UAWJ248 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals. | |||
T70690 | UAWJ246 | ||
UAWJ246 is a SARS-CoV-2 Protease inhibitor (IC50 = 45 nM). UAWJ246 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals. | |||
T82257 | GRL-1720 TFA | SARS-CoV | |
GRL-1720 TFA is a potent SARS-CoV-2 Mpro inhibitor, demonstrating anti-SARS-CoV-2 activity with an EC50 of 15 μM [1]. | |||
T83719 | Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA | ||
Mca-AVLQSGFR-K(Dnp)-K-NH2 serves as a fluorogenic substrate specifically designed for the main protease (Mpro) of the severe acute respiratory syndrome coronavirus (SARS-CoV), also referred to as 3C-like protease (3CLpro... | |||
T78770 | Garcinone B | Angiotensin-converting Enzyme (ACE) | |
Garcinone B, a xanthone derivative naturally isolated from the pericarp of Mangosteen, serves as a potent inhibitor of ACE2 and Mpro, and is utilized in COVID-19 research [1]. | |||
T81203 | SARS-CoV-2-IN-68 | SARS-CoV | |
SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1]. | |||
T63461 | INSCoV-600K(1) | ||
INSCoV-600K(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600K(1) has shown research potential against SARS-CoV-2 infection. | |||
T63483 | INSCoV-614(1B) | ||
INSCoV-614(1B) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-614(1B) has shown research potential for SARS-CoV-2 infection. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T72581 | SARS-CoV MPro-IN-2 | ||
SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus's replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing ... | |||
T32551 | Lamprolobine | ||
Lamprolobine is a bioactive chemical. | |||
T73900 | (±)-Alliin | ||
(±)-Alliin, the principal active component in garlic, functions as a potential inhibitor of SARS-CoV-2's main protease (Mpro) [1]. | |||
T79947 | 10-Hydroxyaloin A | SARS-CoV | |
Hydroxyaloin A (10-10-Hydroxyaloin A) is a potent inhibitor of SARS-CoV-2, demonstrating significant efficacy in binding to the active site of the SARS-CoV-2 main protease (M^pro) [1]. | |||
TN3528 | Bonducellpin D | Antifection | |
Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPK-01341 | 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01339 | 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01343 | 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01342 | 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01338 | 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01340 | 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01337 | 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01345 | 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01347 | 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01344 | 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01346 | 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01335 | 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01336 | 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... | |||
TMPK-01348 | 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) | SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al... |
カタログ番号 | 製品名 | ||
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L1710 | Anti-COVID-19 Compound Library | 1133 compounds | |
A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents; |