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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2030 | Tiplaxtinin | PAI-039,Tiplasinin | PAI-1 , Apoptosis |
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM. | |||
T25915 | Diaplasinin | PAI-749,PAI749,PAI 749 | |
PAI-749 is a selective and effective antagonist agent of plasminogen activator inhibitor 1 (PAI-1). | |||
T13252 | (S)-Rasagiline | TVP1022,S-PAI | Others |
(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson. | |||
T28788 | SK-216 | SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor | |
SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the... | |||
T13252L | (S)-Rasagiline mesylate | TVP1022 (mesylate),S-PAI mesylate | Others |
(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson. | |||
T4254 | TM5441 | PAI-1 , Apoptosis | |
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1). | |||
T3442 | UK-371804 | UK371804 | PAI-1 , Serine Protease |
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers. | |||
T8962 | TM5007 | PAI-1 | |
TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM). | |||
T13257 | Upamostat | PAI-1 , Serine/threonin kinase , Serine Protease | |
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor. | |||
T4255 | TM5275 sodium | TM5275 sodium salt | PAI-1 |
TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1). | |||
T29856 | Aleplasinin | PAZ 417,PAZ417,PAZ-417 | PAI-1 |
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies... | |||
T13408 | ZK824190 | Others , Serine Protease | |
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively). | |||
T21521L | Papain Inhibitor acetate | GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate (70195-20-9 free base) | Others |
Papain Inhibitor acetate (Gly-Gly-Tyr-Arg) is an affinity Ligand for Papain. | |||
T26637 | Antipain dihydrochloride | Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804 | Protease |
Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes. | |||
T76145 | Clostripain | ||
Clostripain (Clostridiopeptidase B), a proteolytic enzyme derived from Clostridium histolyticum, exhibits esterase, amidase, and protease activities. It is notably specific for cleaving carboxy-terminal arginine residues... | |||
T76374 | SPAI-1 | ||
SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [... | |||
T21949 | Calpain Inhibitor XII | ||
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)... | |||
T38931 | Calpain Inhibitor-1 | ||
Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM. | |||
T64183 | PAIR2 | ||
PAIR2 is a potent, selective partial antagonist of IRE1α RNase, effectively occupying the ATP-binding site of IRE1α in cells. This action prevents a potent KIRA from inhibiting XBP1 splicing [1]. | |||
T10685L | Carpaine hydrochloride | Others | |
Carpaine hydrochloride, an alkaloid isolated from Carica papaya Linn, has anti-thrombocytopenic activity. It has the anti-plasmodial activity to prevent malaria. | |||
T14295 | Antipain | Others | |
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations[1][2]. | |||
T63708 | Calpain-2-IN-1 | ||
Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory. | |||
T33578 | Naepaine hydrochloride | ||
Naepaine hydrochloride is a biochemical. | |||
T61634 | Falcipain-2/3-IN-2 | ||
Falcipain-2/3-IN-2 (Compound 12) is a dual falcipain-2 and falcipain-3 inhibitor [1]. | |||
T80551 | Calpain inhibitor V | Mu-Val-HPh-FMK | Antibiotic |
Calpain Inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable, irreversible calpain inhibitor with demonstrated anti-chlamydial activity [1]. | |||
T72439 | Calpain Inhibitor XI | ||
Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders. | |||
T63391 | Calpain Inhibitor-2 | ||
Calpain Inhibitor-2 is a lipophilic calpain inhibitor, and they showed moderate to good anti-proliferative effects in vitro compared to melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells. was able to i... | |||
T23764 | AZ3976 | AZ 3976,AZ-3976 | PAI-1 |
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities. | |||
T68572 | IMD-1622 | ||
IMD-1622 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. | |||
T25217 | CDE-096 | ||
CDE-096 is a plasminogenactivator inhibitor-1 (PAI-1) inactivator. | |||
T70810 | THR-18 | ||
THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncoup... | |||
T22343 | HKB99 | Others | |
HKB99 is a mutational inhibitor of phosphoglycerate mutase 1 (PGAM1).HKB99 increases oxidative stress, activates JNK/c-Jun, and inhibits AKT and ERK[1].HKB99 inhibits the formation of invasive pseudopods and raises the l... | |||
T35520 | Aflatoxin G1-13C17 | Aflatoxin G1-13C17 | |
Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to duckli... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4S0592 | Toddalolactone | (+)-Toddalolactone | PAI-1 |
Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic. | |||
T3876 | Loureirin B | PAI-1 , ERK , Potassium Channel , JNK | |
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw... | |||
T19503 | Papain | Others , Cysteine Protease | |
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries. | |||
T10685 | Carpaine | Others | |
Carpaine, an alkaloid isolated from Carica papaya Linn, has anti-thrombocytopenic activity. It has the anti-plasmodial activity to prevent malaria. |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-01474 | PAI-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
PAI-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A0A024QYT5. | |||
TMPH-02833 | PAI-1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
PAI-1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 44.9 kDa and the accession number is P22777. | |||
TMPY-00629 | PAI-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
PAI-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.6 kDa and the accession number is A6J047. | |||
TMPH-00833 | PAI-1 Protein, Horse, Recombinant | Horse | P. pastoris (Yeast) |
PAI-1 Protein, Horse, Recombinant is expressed in yeast. The predicted molecular weight is 36.2 kDa and the accession number is Q8MI31. | |||
TMPH-00356 | PAI-1 Protein, Feline, Recombinant | Feline | E. coli |
PAI-1 Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29.7 kDa and the accession number is A9NJ78. | |||
TMPY-02559 | PAI-1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
PAI-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A6J047. | |||
TMPH-01869 | PAI-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. PAI-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis ... | |||
TMPH-00832 | PAI-1 Protein, Horse, Recombinant (E. coli) | Horse | E. coli |
PAI-1 Protein, Horse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 32.1 kDa and the accession number is Q8MI31. | |||
TMPH-02834 | PAI-1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-reg... | |||
TMPY-01711 | Serpin B2 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl... | |||
TMPJ-00490 | Serpin A5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent i... | |||
TMPH-03154 | Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) | Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the fun... | |||
TMPH-00347 | Papain Protein, Carica papaya, Recombinant (His) | Carica papaya | E. coli |
Papain Protein, Carica papaya, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.4 kDa and the accession number is P00784. | |||
TMPH-03153 | Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His) | Porphyromonas gingivalis | E. coli |
Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen... | |||
TMPJ-01431 | SARS-CoV-2 Papain-Like Protease Protein | SARS-CoV-2 | E. coli |
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a pap... | |||
TMPH-03598 | Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO) | Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelia... | |||
TMPK-01384 | SARS PLpro/papain-like protease Protein (His) | SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ... | |||
TMPH-03152 | Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His) | Porphyromonas gingivalis | E. coli |
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen... | |||
TMPY-05945 | Influenza A H1N2 (A/Swine/Spain/SF12091/2007) Neuraminidase/NA Protein (His) | H1N2 | HEK293 Cells |
Influenza A H1N2 (A/Swine/Spain/SF12091/2007) Neuraminidase/NA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.6 kDa and the accession number is R4ZD61. | |||
TMPH-03155 | Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) | Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the fun... | |||
TMPY-04894 | SARS-CoV (strain WH20) Plpro/papain-like protease (His) | SARS | E. coli |
SARS-CoV (strain WH20) Plpro/papain-like protease (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.65 kDa and the accession number is AAX16193.1. | |||
TMPH-03648 | Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc) | Trypanosoma cruzi | E. coli |
Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.; The cysteine protease may... | |||
TMPH-03576 | Staphopain A Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Staphopain A Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.4 kDa and the accession number is P81297. | |||
TMPY-05892 | Influenza A H3N2 (A/swine/Spain/33601/2001) Hemagglutinin/HA Protein (His) | H3N2 | HEK293 Cells |
Influenza A H3N2 (A/swine/Spain/33601/2001) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.8 kDa and the accession number is Q288R9. | |||
TMPH-03577 | Staphopain B Protein, S. aureus, Recombinant (GST) | Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and m... | |||
TMPH-03156 | Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) | Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the fun... | |||
TMPY-05682 | SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) | SARS-CoV-2 | E. coli |
SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) is expressed in E. coli expression system. The predicted molecular weight is 36.79 kDa and the accession number is QVD65746.1. | |||
TMPH-03151 | Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His) | Porphyromonas gingivalis | P. pastoris (Yeast) |
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen... | |||
TMPH-00528 | Recombination and repair protein Protein, Enterobacteria phage T4, Recombinant (His) | Enterobacteria phage T4 | E. coli |
Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins. | |||
TMPK-01352 | SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) | SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ... | |||
TMPH-03599 | Streptopain Protein, S. pyogenes, Recombinant (His & SUMO) | Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelia... | |||
TMPH-02414 | Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His) | Porphyromonas gingivalis | E. coli |
Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with C-10xHis tag. The predicted molecular weight is 51.6 kDa and the accession number is Q51817. |
カタログ番号 | 製品名 | ||
---|---|---|---|
L3900 | DNA Damage & Repair Compound Library | 910 compounds | |
A unique collection of 910 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L4020 | NO PAINS Compound Library | 9384 compounds | |
L3980 | DNA Damage and Repair Compound Library Plus | 667 compounds | |
Well-chosen 667 compounds with unique structures targeting DNA damage & repair; |