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T63259 |
PP2A Cancerous-IN-1
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PP2A Cancerous-IN-1 is a potent inhibitor of CIP2A (Cancerous inhibitor of PP2A) and p-Akt that exhibits potent anti-proliferative effects. |
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T2747 |
Endothall
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Others
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Endothall is an effective protein phosphatase 2A (PP2A) inhibitor, exerting inhibitory effects on both PP2A and PP1, with IC50 values of 90 nM and 5 µM, respectively. It exhibits anticancer activity, making it suitable f... |
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T9744 |
MP07-66
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Phosphatase
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MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. |
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T35528 |
TD52
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Apoptosis
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Phosphatase
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Akt
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TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. |
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T70131 |
TPP2a bromide
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TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor. |
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T4449 |
LB100
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LB-100,LB 100 |
Phosphatase
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LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor. |
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T60688 |
MKI-1
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MASTL Kinase Inhibitor-1 |
Others
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MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance... |
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T5182 |
AMZ30
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Others
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AMZ30 is a selective inhibitor of PME-1 (IC50: 600 nM). It also reduces the demethylated form of PP2A in living cells. |
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T3635 |
IQ 1
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IQ1,IQ-1 |
Wnt/beta-catenin
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IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. |
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T2068 |
(Rac)-LB-100
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Phosphatase
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LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation |
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T35528L |
TD52 dihydrochloride
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TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl |
Others
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TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali... |
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T12934 |
SMAP-2
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DT-1154 |
Phosphatase
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SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers . |
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T26164 |
Rubratoxin A
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Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor. |
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T14859 |
Calyculin A
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(-)-Calyculin A |
Others
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Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM). |
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T13095 |
Tautomycin
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Others
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Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticill... |
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T35806 |
N-Stearoylsphingosine
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C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide |
Phosphatase
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N-Stearoylsphingosine is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylati... |
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T78681 |
ITH12711
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Phosphatase
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ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1]. |
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T10060 |
(1S,2S,3R)-DT-061
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Others
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(1S,2S,3R)-DT-061 is an enantiomer of DT-061 which is an orally bioavailable activator of PP2A. |
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T10060L |
DT-061
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Phosphatase
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DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. |
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T31882 |
FTY720-Mitoxy
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FTY 720 Mitoxy,FTY-720-Mitoxy |
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FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria. |
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T83530 |
LB-100
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(Rac)-LB-100 is the racemic form of the compound LB-100, which functions as an inhibitor of protein phosphatase 2A (PP2A) [1]. |
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T82938 |
ATUX-1215
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ATUX-1215, a protein phosphatase 2A (PP2A) activator, diminishes the phosphorylation of ERK, p38, JNK, and Akt, as well as decreases the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals, potentially deceler... |
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T39239 |
TRC-766
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TRC-766, a negative control of RTC-5 (TRC-382), is a compound that exhibits protein phosphatase 2A (PP2A) binding properties while lacking phosphatase activation capabilities. |
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TP2054 |
Calcineurin Autoinhibitory Peptide
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Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). |
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TP1698 |
Microcystin-LA
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Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively. |
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T39183 |
Okadaic acid ammonium salt
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Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50... |
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T83938 |
TAT-PDHPS1
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TAT-PDHPS1 is a peptide inhibitor targeting Yes-associated protein (YAP) signaling, composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. It operates by binding to protein phosphatase 2... |
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T35613 |
Cytostatin (sodium salt)
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Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectivel... |
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T68458 |
Fostriecin (free base)
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Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM... |
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T35777 |
Nodularin
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The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatot... |
