|
TQ0039 |
(±)-Zanubrutinib
|
(±)-BGB-3111 |
BTK
|
|
(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibi. |
|
TQ0242 |
Fenebrutinib
|
GDC-0853 |
BTK
|
|
Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM). |
|
T36287 |
Pirtobrutinib
|
|
BTK
|
|
Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t... |
|
T17220 |
Vecabrutinib
|
SNS-062 |
Tyrosine Kinases
,
BTK
|
|
Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK. |
|
T8636 |
Ibrutinib deacryloylpiperidine
|
IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine |
BTK
|
|
Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM. |
|
T12542 |
Rilzabrutinib
|
PRN1008 |
EGFR
,
Others
,
HER
,
BTK
|
|
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM). |
|
T9408 |
N-piperidine Ibrutinib
|
|
BTK
|
|
N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as S... |
|
T16730 |
Remibrutinib
|
|
BTK
|
|
Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar... |
|
T3626 |
Acalabrutinib
|
ACP-196 |
BTK
|
|
Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre... |
|
TQ0236 |
Tirabrutinib
|
ONO-4059,GS-4059,Velexbru |
BTK
|
|
Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and ... |
|
T5407 |
Branebrutinib
|
BMS986195 |
BTK
|
|
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK). |
|
T33479 |
Monoxerutin
|
Z 12007,MonoHER,7-Monohydroxyethylrutosid |
Antioxidant
|
|
Monoxerutin (MonoHER) is a vasodilator with antioxidant activity that prevents adriamycin-induced cardiotoxicity in mice and is used in the study of acute respiratory syndrome. |
|
T1835 |
Ibrutinib
|
PCI-32765 |
Tyrosine Kinases
,
Src
,
BTK
,
Ligands for Target Protein for PROTAC
|
|
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. |
|
T12311 |
Tirabrutinib hydrochloride
|
ONO-4059 (hydrochloride),GS-4059 (hydrochloride) |
BTK
|
|
Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor. |
|
T13447 |
(R)-Zanubrutinib
|
(R)-BGB-3111 |
BTK
|
|
(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK). |
|
T12152 |
N-piperidine Ibrutinib hydrochloride
|
|
BTK
|
|
N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential ... |
|
T4387 |
Evobrutinib
|
MSC2364447C,M2951 |
BTK
|
|
Evobrutinib(M2951) , also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK), which is important in the development and functioning of various immune cells including B... |
|
T12317 |
Orelabrutinib
|
ICP-022 |
BTK
|
|
Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). |
|
T2603 |
Spebrutinib
|
CC-292,LMK-435,AVL-292 |
Src
,
BTK
|
|
Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. |
|
T63272 |
Edralbrutinib
|
TG-1701 |
BTK
|
|
Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and lymphatic system disorders.Edralbrutinib is used in the study of m... |
|
T67881 |
Acalabrutinib enantiomer
|
R-Acalabrutinib |
BTK
|
|
Acalabrutinib enantiomer (R-Acalabrutinib) is a chemical compound that belongs to the class of Bruton’s tyrosine kinase (BTK) inhibitors. Acarabitinib enantiomers can be used in the study of cancer, autoimmune diseases a... |
|
T9125 |
Tolebrutinib
|
PRN2246,SAR442168 |
BTK
|
|
Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi... |
|
T7584 |
Zanubrutinib
|
BGB-3111 |
BTK
|
|
Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK). |
|
T124659 |
Rhamnocitrin 3-rutinoside
|
|
|
|
Rhamnocitrin 3-rutinoside is a useful organic compound for research related to life sciences. The catalog number is T124659 and the CAS number is 55653-37-7. |
|
T11602 |
Ibrutinib dimer
|
|
Others
|
|
Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM). |
|
T81262 |
Rocbrutinib
|
|
|
|
Rocbrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits antineoplastic properties [1]. |
|
T11601 |
Ibrutinib-d5
|
PCI-32765 D5,Ibrutinib D5 |
Others
|
|
Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor. |
|
T16440 |
Ibrutinib Racemate
|
PCI-32765 (Racemate) |
Others
|
|
Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib. |
|
T39130 |
Elsubrutinib
|
ABBV-105 |
|
|
Elsubrutinib (ABBV-105) is a highly active, potent, and selective orally-administered inhibitor of Bruton's tyrosine kinase (BTK). It irreversibly inhibits the catalytic domain of BTK with an IC50 value of 0.18 μM. Elsub... |
|
T36429 |
Dihydrodiol-Ibrutinib
|
|
|
|
PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.
1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et... |
|
T82714 |
Civorebrutinib
|
WS-413 |
|
|
Civorebrutinib (WS-413) is an inhibitor of Bruton's tyrosine kinase that exhibits antineoplastic activity [1]. |
|
T124715 |
5,7-Dihydroxychromone 7-rutinoside
|
|
|
|
5,7-Dihydroxychromone 7-rutinoside is a useful organic compound for research related to life sciences and the catalog number is T124715. |
|
T124190 |
Amorfrutin A
|
|
|
|
Amorfrutin A is a useful organic compound for research related to life sciences. The catalog number is T124190 and the CAS number is 80489-90-3. |
|
T124309 |
Amorfrutin 4
|
|
|
|
Amorfrutin 4 is a useful organic compound for research related to life sciences. The catalog number is T124309 and the CAS number is 73436-04-1. |
|
T130918 |
Phenethyl rutinoside
|
|
|
|
Phenethyl rutinoside is a useful organic compound for research related to life sciences and the catalog number is T130918. |
|
T72865 |
Sofnobrutinib
|
AS-0871 |
|
|
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) demonstrating IC50 values of 4.2 nM (activated BTK) and 0.39 nM (unactivated BTK). Additionally, it displays an IC50 of 2... |
|
T39056 |
Atuzabrutinib
|
SAR 444727,PRN473 |
|
|
Atuzabrutinib is a potent BTK (Bruton's tyrosine kinase) inhibitor. |
|
T14357 |
Spebrutinib besylate
|
CC-292 (besylate),AVL-292 (benzenesulfonate) |
BTK
|
|
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s). |
|
T126012 |
O-Rutinosylumbelliferone
|
|
|
|
O-Rutinosylumbelliferone is a useful organic compound for research related to life sciences. The catalog number is T126012 and the CAS number is 135064-04-9. |
|
T35844 |
(R)-Pirtobrutinib
|
|
|
|
(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib, and Pirtobrutinib is a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib (LOXO-305) effectively inhibits diverse... |
|
T21357 |
Ibrutinib Interm 0441
|
(S)-1-Boc-3-hydroxypiperidine,(S)-1-Boc-3-piperidinol |
|
|
Ibrutinib Interm 0441 is a piperidine derivative with an amine protecting group and may be used in the preparation of biologically active compounds. |
|
T125008 |
7-O-Methylrutin
|
|
|
|
7-O-Methylrutin is a useful organic compound for research related to life sciences. The catalog number is T125008 and the CAS number is 34202-83-0. |
|
TQ0242L |
Fenebrutinib HCl
|
GDC 0853,RG 7845,GDC-0853,GDC0853,RG7845,RG-7845 |
|
|
Fenebrutinib is orally available inhibitor of Bruton's tyrosine kinase (BTK) with antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen rece... |
|
T11603 |
Ibrutinib-MPEA
|
|
Others
|
|
Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies. |
|
T125918 |
Luteolin 5-rutinoside
|
|
|
|
Luteolin 5-rutinoside is a useful organic compound for research related to life sciences. The catalog number is T125918 and the CAS number is 140380-87-6. |
|
T72653 |
(R)-Elsubrutinib
|
(R)-ABBV-105 |
|
|
(R)-Elsubrutinib ((R)-ABBV-105), a Btk inhibitor, is employed in research related to immune disorders (including rheumatoid arthritis, psoriasis, ankylosing spondylitis, asthma, systemic lupus erythematosus) and cancer. |
|
T79841 |
Cinsebrutinib
|
|
BTK
|
|
Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment. |
|
T124211 |
Amorfrutin B
|
|
|
|
Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4. |
|
T125090 |
Quercetin 3-rutinoside 7-glucoside (Morkotin A)
|
|
|
|
Quercetin 3-rutinoside 7-glucoside (Morkotin A) is a useful organic compound for research related to life sciences and the catalog number is T125090. |
|
T18049 |
Ibrutinib-biotin
|
|
Others
|
|
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK. |
