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カタログ番号 | 製品名 | 別名 | ターゲット |
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T4031 | S1p receptor agonist 1 | S1p-receptor-agonist-1 | S1P Receptor , LPL Receptor |
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. | |||
T62517 | S1p receptor agonist 2 | ||
S1p receptor agonist 2 (compound 1) is an agonist of the S1P5 receptor with a higher selectivity than S1P1 and/or S1P3 receptors.S1p receptor agonist 2 can be used in the endogenous SIP signaling system and in the mitiga... | |||
T6923 | Ozanimod | RPC-1063 | S1P Receptor , LPL Receptor |
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... | |||
T8461 | SKI V | Apoptosis , PI3K , S1P Receptor | |
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity | |||
T83910 | S1PL-IN-31 | Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 | |
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem... | |||
T6403 | Siponimod | BAF-312 | S1P Receptor , LPL Receptor |
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... | |||
TQ0138 | K145 hydrochloride | Apoptosis , S1P Receptor | |
T6085 | PF-543 | Sphingosine Kinase 1 Inhibitor II,PF 543 | Apoptosis , S1P Receptor , Autophagy , LPL Receptor |
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. | |||
T8840 | PF-543 hydrochloride | PF-543 | Apoptosis , S1P Receptor , Autophagy , LPL Receptor |
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. | |||
T28643 | S1P1-IN-Ex26 | ||
S1P1-IN-Ex26 is a potent, selective antagonist of S1P1 receptor. | |||
T12821 | S1PR1 modulator 1 | LPL Receptor | |
T63378 | S1PR1 agonist 1 | ||
S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases. | |||
T62886 | S1PR1 agonist 2 | ||
S1PR1 agonist 2 is a potent agonist of S1PR1. S1PR1 agonist 2 has potential for studies of autoimmune diseases. | |||
T62732 | S1P1 agonist 5 | ||
S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M... | |||
T79817 | S1P1 agonist 6 hemicalcium | LPL Receptor | |
Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ... | |||
T39798 | S1P2 antagonist 1 | ||
S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases. | |||
T72294 | S1P5 receptor agonist-1 | ||
S1P5 Receptor Agonist-1 (example 6) is a highly potent and selective agonist for the S1P5 receptor, exhibiting an EC50 value of 20 nM. | |||
T79816 | S1P1 agonist 6 | LPL Receptor | |
Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1]. | |||
T61639 | S1P1 agonist 4 | ||
S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating a favorable pharmacological profile. | |||
T16833 | S1P1 Agonist III | Others | |
S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM). | |||
T10912 | S1PR1-MO-1 | Others | |
S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases. | |||
T12437 | PF429242 dihydrochloride | S1P Receptor | |
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM). | |||
T2539 | Fingolimod hydrochloride | Fingolimod (FTY720) HCl,FTY720 | TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor |
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells). | |||
T63047 | SLP9101555 | S1P Receptor , LPL Receptor | |
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace... | |||
T61112 | SLF1081851 | LPL Receptor | |
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM. | |||
T38294 | 4-Deoxypyridoxine hydrochloride | S1P Receptor | |
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib... | |||
T38826 | Vibozilimod | Vibozilimod,SCD-044 | S1P Receptor |
Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist . | |||
T26866 | BMS-960 | BMS 960,BMS960 | S1P Receptor |
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research. | |||
T27864 | LX-2931 | LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305 | S1P Receptor |
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis. | |||
T62552 | Ozanimod hydrochloride | ||
Ozanimod (RPC-1063) hydrochloride is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds S1P receptor subtype 1 (S1P1) and S1P5 (S1P5) with high affinity. Ozanimod hydrochloride can be used to study... | |||
T15629 | JTE-013 | Apoptosis , S1P Receptor , LPL Receptor | |
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively). | |||
T10762 | Ceranib1 | Others | |
Ceranib1 is an inhibitor of ceramidase. It inhibits the proliferation of ovarian cancer cells. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide spec... | |||
T22102 | ML-178 | CYM50179 | Others |
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM. | |||
T22101 | ML-031 | S1P Receptor | |
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay. | |||
T14924 | Cenerimod | ACT-334441 | S1P Receptor |
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm... | |||
T76828 | Sonepcizumab | LT 1009 | LPL Receptor |
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi... | |||
T28169 | NIBR-0213 | NIBR 0213 | LPL Receptor |
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. | |||
T2026 | CYM5442 | S1P Receptor , LPL Receptor | |
CYM5442 is an S1P agonist, targeting to Sphingosine. | |||
T10761 | Ceranib-2 | 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one | Apoptosis , S1P Receptor |
T6673 | SKI II | SphK-I2 | Apoptosis , Wnt/beta-catenin , S1P Receptor |
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2. | |||
T22703 | CYM-5520 | CYM 5520 | S1P Receptor , LPL Receptor |
CYM-5520 is a noncompetitive allosteric agonist of S1P2 | |||
T0640 | Benzyl butyl phthalate | BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate | Others , Aryl Hydrocarbon Receptor |
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC. | |||
T24822 | SPM-242 racemate | SPM 242 racemate,SPM242 racemate | |
SPM-242 racemate is an antagonist of S1P(3)-selective. | |||
T37955 | Sphingosine-1-phosphate (d16:1) | Sphingosine-1-phosphate (d16:1) | |
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO... | |||
T70613 | SLP120701 HCl | ||
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Interv... | |||
T28838 | SPM-242 | SPM 242 | |
SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and... | |||
T70614 | SLR080811 HCl | ||
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h... | |||
T36833 | A6770 | ||
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P l... | |||
T26685 | AUY954 HCl | NVP-AUY954,AUY 954,AUY954 hydrochloride,AUY-954,AUY954 | |
AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis in rats. | |||
T34402 | RP-101075 | RP101075 | |
RP-101075 is a etabolite of Ozanimod. It exhibits a similar specificity profile as Ozanimod at the S1P receptor family in vitro, and pharmacodynamic profile in vivo. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T21500 | Sphingosine-1-phosphate | S1P | Endogenous Metabolite , S1P Receptor , LPL Receptor |
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei... | |||
T19778 | 2-ATHBI | THI | Others |
2-ATHBI is a S1P lyase inhibitor. | |||
T7939 | Fingolimod | FTY-720A,FTY-720 | S1P Receptor , PAK , LPL Receptor |
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). |