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T28643 |
Ex26
|
S1P1-IN-Ex26 |
S1P Receptor
|
|
Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling.Ex26 can be used in experimental autoimmune encep... |
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T16833 |
S1P1 Agonist III
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Others
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S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM). |
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T62732 |
S1P1 agonist 5
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S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M... |
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T79816 |
S1P1 agonist 6
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LPL Receptor
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Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1]. |
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T61639 |
S1P1 agonist 4
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S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating a favorable pharmacological profile. |
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T79817 |
S1P1 agonist 6 hemicalcium
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LPL Receptor
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Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ... |
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T38716 |
SAR247799
|
SAR247799,S1P1 agonist 3 |
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SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells a... |
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T28169 |
NIBR-0213
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NIBR 0213 |
LPL Receptor
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NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. |
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T3258 |
Ponesimod
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ACT-128800 |
S1P Receptor
,
LPL Receptor
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Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. |
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T2026 |
CYM5442
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S1P Receptor
,
LPL Receptor
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CYM5442 is an S1P agonist, targeting to Sphingosine. |
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T6403 |
Siponimod
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BAF-312 |
S1P Receptor
,
LPL Receptor
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BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... |
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T6923 |
Ozanimod
|
RPC-1063 |
S1P Receptor
,
LPL Receptor
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Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... |
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T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
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SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... |
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TQ0227 |
Etrasimod
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APD334 |
S1P Receptor
,
LPL Receptor
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Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). |
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T22697 |
CS 2100
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1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
S1P Receptor
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CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist. |
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T60204 |
W140 HBr
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S1P Receptor
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[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM. |
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T10305 |
Amiselimod hydrochloride
|
MT-1303 hydrochloride |
S1P Receptor
,
LPL Receptor
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Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator. |
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T15031 |
CYM50260
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Others
,
LPL Receptor
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CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
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T7360 |
GSK2018682
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S1P Receptor
,
LPL Receptor
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GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). |
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T14924 |
Cenerimod
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ACT-334441 |
S1P Receptor
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Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm... |
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T10385 |
ASP-4058
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S1P Receptor
,
LPL Receptor
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ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice. |
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T4031 |
S1p receptor agonist 1
|
S1p-receptor-agonist-1 |
S1P Receptor
,
LPL Receptor
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S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. |
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T62552 |
Ozanimod hydrochloride
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Ozanimod (RPC-1063) hydrochloride is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds S1P receptor subtype 1 (S1P1) and S1P5 (S1P5) with high affinity. Ozanimod hydrochloride can be used to study... |
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T15032 |
CYM50308
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S1P Receptor
,
LPL Receptor
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CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
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T2539 |
Fingolimod hydrochloride
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Fingolimod (FTY720) HCl,FTY720 |
TRP/TRPV Channel
,
S1P Receptor
,
PAK
,
LPL Receptor
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Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells). |
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T11372 |
GC7 Sulfate
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Autophagy
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GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS act... |
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T27106 |
CYM50374
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CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM. |
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T41144 |
CYM5442 hydrochloride
|
CYM 5442 hydrochloride |
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CYM 5442 hydrochloride is a potent and selective S1P1agonistin vitro(EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain p... |
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T17237 |
VPC 23019
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S1P Receptor
,
LPL Receptor
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VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). |
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T28385 |
PF-462991
|
PF-991,PF991,PF 991,PF 462991 |
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PF-462991 is a S1P1 agonist. |
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T27459 |
GSK2263167
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GSK-2263167,GSK 2263167 |
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GSK2263167 is an agonist of S1P1 receptor. |
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T26557 |
ACT-209905
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ACT 209905,ACT209905 |
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ACT-209905 is an agonist of S1P1 receptor. |
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T26867 |
BMS-986104 HCl
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BMS986104,BMS-986104,BMS 986104 |
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BMS-986104 is a potent and selective S1P1 receptor modulator. |
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T32005 |
GSK1842799
|
GSK 1842799 |
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GSK1842799 is a selective S1P1 receptor agonist with good oral bioavailability. |
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T71564 |
GSK2018682 HCl
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GSK2018682 is a novel sphingosine-1-phosphate receptor 1 (s1p1) and 5 (s1p5) agonist. |
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T68678 |
VPC 24191
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VPC 24191 is a sphingosine 1-phosphate (S1P1/3) receptor agonist. |
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T31107 |
CS-0777
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CS0777,CS 0777 |
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CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator). |
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T29971 |
AMG-369
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KB74649,KB 74649,AMG369,KB-74649 |
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AMG-369 (KB74649) is an effective S1P1/S1P5 dual agonist, with limited activity in S1P3, but no activity in S1P2/S1P4. |
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T71392 |
(R)-FTY-720 Vinylphosphonate
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(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity. |
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T26962 |
CBP-307
|
CBP307 |
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CBP-307 is a selective second generation S1P1 (a G-protein coupled receptor -GPCR) modulator. |
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T32006 |
GSK-2262167 sodium
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GSK-2262167,GSK2262167,GSK 2262167 |
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GSK-2262167 is a potent S1P1 agonist, as effective as fingolimod in collagen-induced arthritis models, and shows good preclinical pharmacokinetic properties. |
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T71069 |
GSK1842799 HCl
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GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3. GSK1842799 demonstrated good oral bioa... |
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T12780 |
RP-001
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Others
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RP-001 is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. |
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T38336 |
W140 (trifluoroacetate salt)
|
W140 (trifluoroacetate salt) |
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Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its ac... |
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T12780L |
RP-001 hydrochloride
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Others
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RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. |
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T30529 |
BMS-520
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BMS-520 is a potent, selective S1P1 agonist that has shown impressive efficacy when administered orally in a rat model of arthritis and in a mouse model of experimental autoimmune encephalomyelitis (EAE) with multiple sc... |
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T21916 |
TC-SP 14
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TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its ... |
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T8840 |
PF-543 hydrochloride
|
PF-543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
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PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
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T37955 |
Sphingosine-1-phosphate (d16:1)
|
Sphingosine-1-phosphate (d16:1) |
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C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO... |
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T37548 |
Azido-FTY720
|
azido-FTY720 |
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FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survi... |
