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T11279 |
FGFR1/DDR2 inhibitor 1
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Discoidin Domain Receptor (DDR)
,
FGFR
,
Others
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FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. |
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T11847L |
Liarozole
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R75251 dihydrochloride |
P450
,
Retinoid Receptor
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|
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... |
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T7417 |
Avatrombopag
|
YM477,AKR-501,E5501 |
Thrombin
,
Thrombopoietin Receptor
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|
Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production. |
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T80378 |
Tilapia piscidin 3
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|
|
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Tilapia piscidin 3, an antimicrobial peptide, exhibits antibacterial properties effective against both gram-positive and gram-negative bacteria. It has demonstrated minimum inhibitory concentrations (MICs) of 2.44 µg/mL ... |
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T30152 |
Ascididemin
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Leptoclinidinone,CRL 8274,NSC-675670,NSC 675670,NSC675670 |
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Ascididemin can be regarded as a fused phenanthroline with quinoline. |
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T124820 |
Piscidic acid
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Piscidic acid is a useful organic compound for research related to life sciences and the catalog number is T124820. |
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T11151 |
Ecteinascidin-Analog-1
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Others
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Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities. Ecteinascidin-Analog-1 is a useful intermediate for chemical sythesis of Ecteinascidin analogues. |
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T80286 |
TP4 (Nile tilapia piscidin)
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|
Necroptosis
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TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial strains with a minimum inhibitory concentration (MIC) ranging f... |
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TP1475 |
Piscidin-1 (22-42)
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|
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Piscidin-1 (22-42) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides). |
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TP1521 |
Piscidin-1 (22-42) (TFA)
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|
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Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides). |
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T60248 |
4-Aminobenzamidine dihydrochloride
|
p-Aminobenzamidine dihydrochloride |
Serine Protease
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|
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inh... |
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T78805 |
AD4
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|
Others
,
PROTACs
|
|
AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting i... |
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T36674 |
DMU-212
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|
Apoptosis
,
ERK
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DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2... |
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T78305 |
Briquilimab
|
JSP-191 |
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Briquilimab (JSP-191), a non-toxic humanized monoclonal antibody, targets CD117 (c-Kit) to deplete hematopoietic stem cells (HSCs), providing a safe approach for clearing host marrow niche to facilitate adequate donor HS... |
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T71252 |
PC-046
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|
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PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... |
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T69822 |
Ritlecitinib tosylate
|
|
|
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Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this... |
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T68346 |
KRN383
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|
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KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prol... |
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T69821 |
AMP423
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|
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AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma ... |
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T35675 |
SW203668 (trifluoroacetate salt)
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|
|
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SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other... |
