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T21419 |
Diphenhydramine
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Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255 |
Histamine Receptor
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Diphenhydramine (Syntedril), a first-generation antihistamine possessing antiemetic, antitussive, anticholinergic, and sedative properties, is mainly used in the treatment of allergies. Diphenhydramine is also used in th... |
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T26253 |
Tecastemizole
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Norastemizole,R-43512,R43512,R 43512,T 1348 |
Histamine Receptor
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Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects. |
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T15259 |
Evatanepag
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CP-533536 free acid |
Prostaglandin Receptor
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Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... |
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T3520 |
Setipiprant
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KYTH-105,ACT-129968 |
GPR
,
Prostaglandin Receptor
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Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... |
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T21390 |
Fexofenadine
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Carboxyterfenadine,Telfast,MDL 16.455,Allegra |
Histamine Receptor
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Fexofenadine (Carboxyterfenadine), an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is... |
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T7084 |
2-Bromo-4'-hydroxyacetophenone
|
SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide |
Phosphatase
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2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH... |
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T24771 |
SCH-336
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SCH336,SCH 336 |
Cannabinoid Receptor
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SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 red... |
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T29545 |
Acamelin
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Acamelin is a quinone isolated from the Australian black wood acacia melanoxylon. It is responsible for the allergy-inducing properties of the species. |
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T71053 |
AHR-5333 mandelate
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AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to in... |
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T28372 |
PF-06462894
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PF 6462894,PF-6462894,PF6462894 |
|
|
PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM) with favorable properties. PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model. |
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TQ0032L |
Rosiptor acetate
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AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate |
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Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast ... |
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T26447 |
A 78773
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A78773,A-78773 |
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A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tis... |
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T81590 |
OVA peptide
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Ovalbumin (OVA) peptide, primarily found in egg white, is a class I (Kb)-restricted peptide epitope presented by H-2Kb, the mouse MHC (major histocompatibility complex) class I gene product. It has garnered significant a... |
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T78641 |
ER-27319
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Syk
|
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ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory conce... |
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T37604 |
ITK inhibitor
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|
|
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Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept... |
