|
T39710 |
ARV-471
|
Vepdegestrant |
Estrogen Receptor/ERR
|
|
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. |
|
T6798 |
Tretazicar
|
5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 |
DNA Alkylator/Crosslinker
,
DNA Alkylation
|
|
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cy... |
|
T17159 |
Treosulfan
|
NSC 39069,Treosulphan |
DNA Alkylator/Crosslinker
,
DNA Alkylation
|
|
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types. |
|
T7750 |
N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea
|
|
Others
|
|
N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(9R)-6'-Methoxycinchonan-9-yl]- Thiourea is a cinchona alkaloid-derived bifunctional catalyst. |
|
T15178 |
DTRIM24
|
|
Others
|
|
dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24. |
|
T18728 |
Sulfo-SMCC sodium
|
|
Others
|
|
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable i... |
|
T4382 |
Proguanil hydrochloride
|
Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil |
Others
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
,
Parasite
|
|
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ... |
|
T19168 |
9-Azido-Neu5DAz
|
|
Others
|
|
9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent. |
|
T26803 |
Bibw 22
|
Bibw22,Bibw-22 |
|
|
Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport. |
|
T28846 |
SR16835
|
AT-202,AT202,SR 16835,SR-16835 |
|
|
SR16835 is a NOP receptor agonist, with low-affinity bifunctional activity at the μ opioid receptor. |
|
T25140 |
BCH 2763
|
BCH2763,BCH-2763 |
|
|
BCH 2763 is an effective, selective bifunctional thrombin inhibitor that blocks both the anion binding exosite and the active catalytic site. |
|
T17469 |
Azide-PEG3-Sulfone-PEG3-azide
|
|
Others
|
|
Azide-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based bifunctional molecule, specifically designed as a PROTAC linker for the synthesis of PROTACs[1]. |
|
T14163 |
Ald-Ph-amido-C2-PEG3-NH-Boc
|
|
Others
|
|
Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. |
|
T19207 |
BFCAs-1
|
|
Others
|
|
BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging. |
|
T16181 |
N-(Azido-PEG2)-N-Boc-PEG4-Boc
|
|
Others
|
|
N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based bifunctional linker employed for the synthesis of PROTACs. |
|
T68272 |
Batefenterol Succinate
|
|
|
|
Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. |
|
T14267 |
Aminooxy-PEG3-C2-NH-Boc
|
|
Others
|
|
Aminooxy-PEG3-C2-NH-Boc is a PEGylated PROTAC linker utilized in the synthesis of PROTACs, an emerging class of bifunctional molecules for targeted protein degradation[1]. |
|
T40648 |
NOTA
|
|
|
|
NOTA, a bifunctional chelate, serves as a foundation for PET imaging tool construction, probe design, and signal amplification through the multivalent effect. |
|
T81433 |
P-NH2-CHX-A"-DTPA
|
|
|
|
p-NH2-CHX-A"-DTPA is a bifunctional chelating agent [1]. |
|
T16234 |
N-Mal-N-bis(PEG4-NHS ester)
|
|
Others
|
|
N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker utilized for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1]. |
|
T18834 |
Thiol-PEG-CH2COOH (MW 5000)
|
|
Others
|
|
Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1]. |
|
T18744 |
T-Boc-Aminooxy-PEG7-bromide
|
|
Others
|
|
t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-based bifunctional linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1]. |
|
T70925 |
GS-5759
|
|
|
|
GS-5759 is a bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action. |
|
T14449 |
Azido-PEG4-hydrazide-Boc
|
|
Others
|
|
Azido-PEG4-hydrazide-Boc is a polyethylene glycol (PEG)-based bifunctional linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. |
|
T41024 |
FmocNH-PEG4-t-butyl acetate
|
FmocNH-PEG4-t-butyl acetate |
|
|
FmocNH-PEG4-t-butyl acetate is a polyethylene glycol (PEG)-derived PROTAC linker employed for the synthesis of PROTACs, bifunctional molecules designed to degrade target proteins. |
|
T18080 |
M-PEG-acrylate (MW 30000)
|
|
Others
|
|
m-PEG-acrylate (MW 30000) is a polyethylene glycol (PEG)-based bifunctional linker commonly employed in the chemical synthesis of proteolysis targeting chimeras (PROTACs)[1]. |
|
T77936 |
PROTAC BRD9 Degrader-4
|
|
PROTACs
|
|
PROTAC BRD9 Degrader-4 is a bifunctional degrader targeting BRD9, designed for cancer research applications. |
|
T34173 |
P-SCN-Bn-HOPO
|
|
|
|
p-SCN-Bn-HOPO is an excellent bifunctional chelating agent for (89)Zr ImmunoPET, with low background, good tumor-organ contrast, and importantly, very low bone uptake for BT474 breast cancer imaging. |
|
T81384 |
PROTAC BRD9 Degrader-3
|
|
PROTACs
|
|
PROTAC BRD9 Degrader-3 is a bifunctional degrader targeting BRD9, utilized in cancer research. |
|
T18413 |
N-Desthiobiotin-N-bis(PEG4-t-butyl ester)
|
|
Others
|
|
N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound employed for the synthesis of PROTACs, which are bifunctional molecules designed for targeted protein degradation[1]. |
|
T31584 |
DST Crosslinker
|
DST Cross linker,DST Cross-linker |
|
|
DST crosslinker(disuccinimide tartarate) is an isotype bifunctional, cleavable crosslinker (cleavable by an oxidizer) for applications that require crosslinking cleavability and that do not interfere with protein disulfi... |
|
T81385 |
PROTAC BRD9 Degrader-2
|
|
PROTACs
|
|
PROTAC BRD9 Degrader-2 is a bifunctional compound designed for the targeted degradation of BRD9 in cancer research applications. |
|
T17962 |
Fmoc-N-PEG36-acid
|
|
Others
|
|
Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis. It has been designed specifically for constructing PROTACs, which are bifunctional molecules capable of recruiting target ... |
|
T82537 |
D-MoDE-A (1)
|
|
LYTACs
|
|
D-MoDE-A (1) is a bifunctional small molecule that facilitates extracellular protein degradation via the asialoglycoprotein receptor (ASGPR). |
|
T77155 |
Dalutrafusp alfa
|
|
|
|
Dalutrafusp alfa (AGEN-1423; GS-1423) is a bifunctional antibody targeting CD73 and TGF-β, components of the immunosuppressive pathway [1]. |
|
T26049 |
RB 6145
|
RB6145,RB-6145 |
|
|
RB 6145 is a bifunctional nitroimidazole, a prodrug of the hypoxic cell radiosensitizer RSU 1069, which has reduced toxicity compared to RSU 1069. It has hypoxic cell preferential cytotoxicity and antitumor therapeutic a... |
|
T11938L |
Macropa-NH2
|
|
Others
|
|
Macropa-NH2 is a bifunctional analog of macropa, a carrier molecule that is often coupled to antibodies and is often used as a chelator in cancer research. |
|
T81779 |
M-MoDE-A (2)
|
|
LYTACs
|
|
M-MoDE-A (2) is a bifunctional small molecule that facilitates the degradation of extracellular proteins via the asialoglycoprotein receptor (ASGPR). |
|
T31588 |
Dynasylan 1161
|
Y 9138 |
|
|
Dynasylan 1161 is a bifunctional organosilane that reacts with suitable polymers. Dynasylan 1161 can be combined with a variety of inorganic substrates in the presence of water. |
|
T32026 |
GYKI-13324
|
GYKI 13324,GYKI13324 |
|
|
GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or... |
|
T69149 |
L2-b
|
|
|
|
L2-b is a bifunctional Aβ-interacting, metal-chelating molecule that modulates ROS production in, and improves survival of neuroblastoma cells incubated in the presence of Aβ along with Copper or Zinc. In cell-free aggre... |
|
T28464 |
P-SCN-Bn-TCMC HCl
|
p-SCN-Bn-TCMC |
|
|
p-SCN-Bn-TCMC is a bifunctional chelator, it contains a powerful chelator TCMC and reactive tioisocyante linker. TCMC is a powerful chelator with capability to strongly bind radio-isotopic heavy metal ion, which are wide... |
|
T82560 |
Di-Ellipticine-RIBOTAC
|
|
PROTACs
|
|
Di-Ellipticine-RIBOTAC is a bifunctional small molecule that effectively diminishes the r(G4C2) repeat expansion associated with c9ALS/FTD both in vitro and in vivo, showcasing therapeutic potential in amyotrophic latera... |
|
T80588 |
Bintrafusp alfa
|
M7824,MSB0011359C |
|
|
Bintrafusp alfa (M 7824), a pioneering bifunctional fusion protein, integrates the extracellular domain of TGF-βRII with a human IgG1 monoclonal antibody that inhibits the programmed cell death ligand. This compound is u... |
|
T79618 |
M3/PDE4 modulator-1
|
|
|
|
M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor. When administered intravenously at concentrations ranging from 10 to 1000 nM/kg, this co... |
|
T82866 |
Biotin-PEG-Biotin (MW 20000)
|
|
|
|
Biotin-PEG-Biotin (MW 20000) is a bifunctional PEG derivative featuring biotin labels at each terminal end. As an enzyme co-factor, biotin facilitates protein labeling, while PEG, known for its hydrophilic nature and low... |
|
T68942 |
Caricotamide
|
|
|
|
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro... |
|
T81035 |
TAT-NSF222 Fusion Peptide
|
|
|
|
TAT-NSF222 Fusion Peptide is a bifunctional polypeptide comprising a TAT domain, facilitating cellular uptake via macropinocytosis, and an NSF domain, which acts as an inhibitor of N-ethylmaleimide-sensitive factor (NSF)... |
|
T78352 |
N-acetylglucosamine-1-P uridyltransferase (AGX1)
|
GlcNAc1pUT |
|
|
N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) is a bifunctional enzyme that couples with GlcNAc-1-P and UTP to catalyze the synthesis of UDP-GlcNAc through an uridyltransfer reaction. It exhibits acetyltr... |
|
T78879 |
CXCR4-IN-2
|
|
CXCR
|
|
CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colore... |
