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T12937 |
SMS1-IN-1
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Others
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T21508 |
Anhydrotetracycline hydrochloride
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Antibacterial
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Antibiotic
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Anhydrotetracycline (hydrochloride) is a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes. |
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T7092 |
NADPH tetrasodium salt
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Others
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Ferroptosis
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Endogenous Metabolite
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NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an end... |
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T19596 |
UDP-GlcNAc Disodium Salt
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Uridine 5′-diphospho-N-acetylglucosamine,UDP-α-D-N-Acetylglucosamine Disodium Salt |
Others
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UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). |
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T8934 |
(6R)-FR054
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FR054 |
Apoptosis
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Others
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(6R)-FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. |
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T11019 |
DHODH-IN-1
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Dehydrogenase
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DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway. |
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T9468 |
FR054
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Others
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FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su... |
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T37185 |
D-(-)-3-Phosphoglyceric acid disodium
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3-Phospho-D-glyceric acid disodium |
Others
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D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine... |
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T14884 |
CBR-5884
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Others
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Dehydrogenase
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CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h... |
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T24904 |
TSI-01
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TSI 01 |
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TSI-01 is a selective PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 inhibitor. |
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T14882 |
CB30865
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ZM 242421 |
Others
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CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway. |
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T68218 |
S 8660
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S 8660 is an analogue of brequinar sodium that inhibits the pyrimidine biosynthetic pathway. |
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T16712 |
(R)-Pantetheine
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Pantetheine |
Others
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(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine play a key role in metabolism . |
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T40178 |
6,7-Dimethyl-8-ribityllumazine
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6,7-Dimethyl-8-ribityllumazine is a biosynthetic precursor of Riboflavin (RBF). It serves as a noncovalently bound fluorophore of Lumazine protein (LumP), an accessory protein that exhibits fluorescence. |
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T71865 |
DSM43
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DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The p... |
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T38085 |
Neoantimycin
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Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity. It is structurally similar to antimycin despite being produced by an unrelated species of Streptomyces. The biosynthe... |
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T37617 |
Leukotriene B3
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LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemota... |
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T74986 |
MRV03-070
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MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (IC 50) value of 69 nM. |
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T37789 |
Riboflavin 5'-monophosphate (sodium salt hydrate)
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Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA ... |
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T36365 |
KAPA (hydrochloride)
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KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid |
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Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized f... |
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T80982 |
TIS108
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TIS108, a triazole-type strigolactone biosynthetic inhibitor, impedes embryogenesis in Arabidopsis and diminishes the concentration of 2′-epi-5-deoxystrigol (epi-5DS) in rice [1]. |
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T60833 |
Mycobactin-IN-2
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Mycobactin-IN-2 (compound 49) is an inhibitor of mycobactin biosynthesis that binds to salicyl-AMP ligase (MbtA). MbtA is a key enzyme of mycobactin biosynthetic pathway [1]. |
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T40753 |
Cytidine-5'-triphosphate
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Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP |
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Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is s... |
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T69623 |
Tridemorph
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Tridemorph is a sterol biosynthetic inhibitor. It is a fungicide used to control Erysiphe graminis. It was developed by BASF in the 1960s who use the trade name Calixin. The World Health Organization has categorized it a... |
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T77789 |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt
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LPA sodium salt |
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Oleoyl-L-alpha-lysophosphatidic acid sodium salt is an essential cell membrane biosynthetic metabolite that mediates signal transduction by interacting with G protein-coupled receptors (GPCRs) (ie, LPA receptors). It is ... |
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T63779 |
RmlA-IN-2
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RmlA-IN-2 is a potent inhibitor of 1-phosphoglucose thymidyltransferase (RmlA) (IC50: 0.303 μM).RmlA-IN-2 affects the monosaccharide l-rhamnose biosynthetic pathway and affects bacterial cell wall permeability. |
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T36740 |
Guanosine 5’-diphosphate (sodium salt hydrate)
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Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR... |
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T60486 |
Mycobactin-IN-1
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Mycobactin-IN-1 (compound 44) is a pyrazoline analogue. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA) which is a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 is an inhibitor of mycobactin biosy... |
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T35428 |
β-Rubromycin
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β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, ... |
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T35979 |
Benastatin C
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Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Be... |
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T35978 |
Benastatin A
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Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benast... |
