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T9080 |
Plecanatide
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Guanylate cyclase
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Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. |
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T0786 |
Clidinium bromide
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Ro 2-3773 |
AChR
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Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
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T2542 |
Prucalopride
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R-93877 |
5-HT Receptor
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Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. |
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T16083 |
Mizagliflozin
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GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT
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Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... |
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T11852 |
リナクロチド
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Guanylate cyclase
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Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. |
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T3355 |
Naloxegol oxalate
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NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate |
P450
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Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. |
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T6307 |
Lubiprostone
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SPI-0211,RU-0211 |
Chloride channel
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Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation. |
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T83981 |
YKP 10811
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Relenopride |
5-HT Receptor
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YKP 10811 (Relenopride) is a novel 5-HT4 receptor partial agonist, which accelerates gastric and colonic transport, and can be used to study irritable bowel syndrome with constipation. |
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T1551 |
Tegaserod maleate
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HTF-919,SDZ-HTF-919 |
5-HT Receptor
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Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
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T11827 |
Pradigastat
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ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase
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Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. |
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T38507 |
Renzapride
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BRL 24924 |
5-HT Receptor
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Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
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T0299 |
Lactitol monohydrate
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D-Lactitol monohydrate |
Others
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Lactitol monohydrate (D-Lactitol monohydrate) is a disaccharide analog of lactulose. It has been widely used to treat constipation and hepatic encephalopathy. |
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T15209 |
Elobixibat
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AZD 7806,A 3309 |
Others
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Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation. |
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T28043L |
Minesapride
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5-HT Receptor
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Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation. |
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T6414 |
Bisacodyl
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Fenilaxan,Dulcolax,Brocalax |
Others
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Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. |
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T0929 |
Docusate sodium
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Aerosol OT,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate |
Opioid Receptor
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HSV
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Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinic... |
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T21422 |
Methylnaltrexone bromide
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Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 |
Opioid Receptor
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Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... |
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T0056 |
Oxeladin citrate
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Others
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Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add... |
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T68123 |
Oxodipine
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Calcium Channel
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Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri... |
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T28512 |
Relenopride hydrochloride
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YKP-10811,YKP10811,YKP 10811,Relenopride HCl |
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Relenopride, a 5-HT agonist, is used potentially for the treatment of chronic constipation. |
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T11852L |
Linaclotide acetate
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MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775 |
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Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. |
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T1242L |
Alvimopan monohydrate
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Alvimopan monohydrate is a mu-opioid receptor antagonist that intended for the treatment of constipation in patients who take opiates for pain. |
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T71738 |
DRAinh-A250
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DRAinh-A250 is a SLC26A3 inhibitor which blocks colonic fluid absorption and reduces constipation. |
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T30236 |
Axelopran
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TD 1211,TD-1211,TD1211 |
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Axelopran(TD-1211) is potentially useful for the treatment of opioid-induced constipation, it is a potent, selective, and peripherally-restricted μ-, κ-, and δ-opioid receptor antagonist. |
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T35046 |
Velusetrag
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TD 5108,TD5108,TD-5108 |
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Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome. |
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T33583 |
Naldemedine
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S-297995,S297995,Naldemedine,S 297995,S297,995,S 297,995,S297,995;Naldemedine,S-297,995 |
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Naldemedine (S 297995) is a peripheral selective μ-opioid receptor antagonist being developed by Shionogi for the treatment of opioid-induced adverse reactions, including constipation, nausea, and vomiting. They are usua... |
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T38482 |
MM 419447
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MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. |
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T62973 |
DS-3801b
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DS-3801b is a potent, non-macrolide GPR38 agonist and has the potential to be a novel gastrointestinal agonist for the study of functional gastrointestinal disorders (e.g. gastroparesis, chronic constipation). |
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T78604 |
SLC26A3-IN-3
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SLC26A3-IN-3 (compound 4az), a potent SLC26A3 inhibitor with an IC50 of 40 nM, is utilized for constipation and cystic fibrosis research [1]. |
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T72809 |
(S)-Renzapride
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(S)-BRL 24924 |
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(S)-Renzapride ((S)-BRL 24924), an isomer of Renzapride, acts as a 5-HT4 receptor agonist with a K_i value of 115 nM and also antagonizes 5HT2b and 5HT3 receptors. It is utilized in studies focused on constipation-predom... |
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T36374 |
Naloxegol (NKTR-118)
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|
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Naloxegol (NKTR-118; AZ-13337019) is an opioid-receptor antagonist[1].
[1]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Ju... |
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T72515 |
Elobixibat hydrate
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A 3309 hydrate ; AZD 7806 hydrate,AZD 7806 hydrate,A 3309 hydrate |
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Elobixibat hydrate, a potent inhibitor of the ileal bile acid transporter (IBAT), exhibits IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human, mouse, and canine IBAT, respectively. It is utilized i... |
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TMIH-0209 |
Elobixibat-d5
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Elobixibat-d5 is a deuterated compound of Elobixibat. Elobixibat has a CAS number of 439087-18-0. Elobixibat is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and c... |
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T70929 |
Naldemedine tosylate
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S-297995 tosylate |
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Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards h... |
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T70070 |
Cisapride tartrate
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Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisa... |
