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T22285 |
Carboprost
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15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α |
Prostaglandin Receptor
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Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone. |
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T1433 |
Ritodrine hydrochloride
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DU21220,Ritodrine HCl,NSC 291565 |
Adrenergic Receptor
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Ritodrine hydrochloride (NSC 291565) binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Ritodrine hydrochloride (NS... |
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T28855 |
SSR126768A
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SSR-126768A,SSR 126768A |
Oxytocin Receptor
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SSR126768A is a novel and selective, orally active and potent oxytocin (OT) receptor antagonist with inhibitory effects on uterine contractions for the prevention of preterm labor. |
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T14326 |
AS-35
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Others
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T12255 |
NS19504
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Potassium Channel
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NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1]. |
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T5148 |
Atosiban acetate
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RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 |
Oxytocin Receptor
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Vasopressin Receptor
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Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... |
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T1475 |
Fesoterodine fumarate
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Toviaz,SPM 907 |
AChR
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Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
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T1435 |
Praziquantel
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Pyquiton,Droncit,Biltricide |
Calcium Channel
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Antibiotic
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Parasite
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Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur... |
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T72038 |
YM-58790
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YM-58790 free base |
AChR
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YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder c... |
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TP2106L |
Urantide acetate(669089-53-6 free base)
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Neurotensin Receptor
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Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ... |
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T68123 |
Oxodipine
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Calcium Channel
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Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri... |
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TP1198 |
Sincalide ammonium
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SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium |
cholecystokinin
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Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secr... |
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T33449 |
ML 1035
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ML103,ML-1035 |
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ML 1035 is a benzamide that elicits contractions from guinea-pig non-stimulated ileum. |
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TP2480 |
Locustamyotropin
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Lom-MT,Locustamyotropin I,Lom MT,LomMT,Gly-ala-val-pro-ala-ala-gln-phe-ser-pro-arg-leu-NH2 |
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Locustamyotropin is a novel peptide isolated from Leucophae maderae; stimulates the spontaneous contractions of the hindgut of Leucophaea maderae. |
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T69053 |
ANAPP3
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ANAPP3 is a P2x-purinoceptor antagonist. It affects contractions in various muscle groups and tissues. |
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T20522 |
Acetylcholine perchlorate
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AI351678,AI3-51678,AI3 51678 |
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Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle... |
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T15105 |
Dexloxiglumide
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Others
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Dexloxiglumide, an active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). It is a selective antagonist of cholecystokinin type A (CCKA) receptors. |
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T28738 |
SDZ-216525
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SDZ 216525,SDZ216525 |
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SDZ-216525, a 5-HT1A receptor antagonist, inhibits the tracheal contractions induced both by NKA (10 nM-3 microM) and 5-HT (10 nM-10 microM) (n=4-10). |
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T71029 |
RCC-36 HCl
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Rcc 36 is an active metabolite of temiverine that has inhibitory actions toward the atropine-resistant part of contractions, which may be related to the calcium antagonistic actions of these compounds. |
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T68241 |
Wy 27127
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Wy 27127 is an alpha 2-adrenoceptors antagonist that has estimated potency based on ability to block clonidine-induced inhibition of electrically-evoked contractions of the rat isolated vas deferens. |
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T80914 |
Tyr0-Neurokinin B
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Tyr-NKB |
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Tyr0-Neurokinin B (Tyr-NKB), an analogue of Neurokinin B, induces contractions in the bladder [1]. |
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T28131 |
Napamezole
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WIN51181,WIN-51181,WIN 51181 |
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Napamezole is an α2 adrenergic receptor antagonist. Napamezole antagonizes methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. Napamezole reverses clonidine-induced decreased in twitch... |
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T8437 |
3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox
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Others
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3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox Antagonism to 2-methyl-5-HT induced contractions in guinea pig ileum |
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T61309 |
(R)-Oxybutynin
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(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitive... |
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T71935 |
WIN 66306
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WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated g... |
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T76189 |
Phyllomedusin
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Phyllomedusin, a tachykinin decapeptide, acts as an NK1 receptor agonist. It exhibits vasodilatory effects and induces pyloric contractions [1] [2] [3]. |
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T29183 |
YM-430
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YM-15430,YM-15430-1,YM-154301,YM-15430-2,YM430,YM-15430-3 |
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YM-430 is a β1 adrenergic receptor antagonist and a calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contra... |
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T75861 |
ANQ-11125 TFA
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ANQ-11125 TFA is a potent, selective motilin antagonist, exhibiting a pKd of 8.24. It effectively inhibits motilide-induced contractions in rabbit models, as demonstrated in vitro [1] [2]. |
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T36771 |
11-deoxy Prostaglandin F1α
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11-deoxy Prostaglandin F1α |
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11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that ... |
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T81626 |
Obestatin(11-23)mouse, rat
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Obestatin(11-23)mouse, rat is a polypeptide that regulates energy balance and suppresses appetite by reducing food consumption, body weight, and jejunal contractions in rodents [1]. |
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TP2104 |
UFP-803
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UFP 803 |
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Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-... |
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T69215 |
Ambrein
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Ambrein is a triterpene alcohol that is the chief constituent of ambergris, a secretion from the digestive system of the sperm whale, and has been suggested as the possible active component producing the supposed aphrodi... |
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TP2106 |
Urantide
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Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acet... |
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T4996 |
Atosiban
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RWJ22164,RW22164 |
Oxytocin Receptor
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Vasopressin Receptor
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Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated rel... |
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T76430 |
GR 87389
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GR 87389, a potent NK2 receptor antagonist, competitively inhibits GA 64349-induced contractions in smooth muscle strips of the human detrusor, prostate, and prostatic urethra [1] [2]. |
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T37794 |
Rec 15/2615 (hydrochloride)
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Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respective... |
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T78563 |
[Leu13]-Motilin
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KW-5139 |
Motilin Receptor
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[Leu13]-Motilin (KW-5139) is an analogue of the gastrointestinal hormone motilin that induces concentration-dependent contractions in rabbit gastrointestinal tissues, including the gastric antrum, duodenum, jejunum, ileu... |
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T69133 |
Etozolin HCl
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Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vasc... |
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T37919 |
Prostaglandin F1α
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PGF1α,Prostaglandin F1α |
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Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with... |
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T71155 |
NP-1815-PX
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P2X Receptor
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NP-1815-PX is a selective P2X4R antagonist with demonstrated anti-inflammatory effects and the capability to alleviate pain in chronic pain models. Additionally, it impedes contractions of guinea pig tracheal and bronchi... |
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T73083 |
Nipradolol
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KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351 |
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Nipradolol (KT-210; K-351), an alpha-1-adrenergic receptor antagonist, effectively inhibits the elevation of intraocular pressure (IOP) induced by Phenylephrine in an albino rabbit model and suppresses noradrenaline (NA)... |
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T76211 |
[Asp5]-Oxytocin acetate
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[Asp5]-Oxytocin acetate is a neurohypophyseal hormone analogue positioned at the 5-position, noted for its significant biological activity. It stimulates uterine contractions in vitro, an effect that is amplified by the ... |
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T37319 |
5β-Dihydroprogesterone
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5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u... |
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TP1747 |
Bradykinin (1-6)
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Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).Bradykinin (1-6) is a fragment of bradykinin. Bradykinin activates pai... |
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T21787 |
B-HT 933 dihydrochloride
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Azepexole dihydrochloride (B-HT 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for α2A-, α2B-, and α2C-adrenoceptor subtypes with pKis of 8.3, 7.6, and 7.5, respectively [1]. It elicits a co... |
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T70153 |
Pipoxolan hydrochloride
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Pipoxolan (HCl) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhib... |
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T69661 |
Pipoxolan (free base)
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Pipoxolan (free base) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and... |
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T73930 |
(-)-Eseroline fumarate
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(-)-Eseroline fumarate, a metabolite of the acetylcholinesterase inhibitor Physostigmine, promotes lactic acid dehydrogenase (LDH) leakage from cancer cells and triggers adenine nucleotides and 5-hydroxytryptamine (5-HT)... |
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T37620 |
Leukotriene C4 methyl ester
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Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met... |
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T80172 |
Stromatoxin 1
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Potassium Channel
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Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3. It selectively targets K(V)2.1 and K(V)2.2 channel subunits, wh... |
