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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T12516	Polyinosinic-polycytidylic acid sodium	Poly(I:C) sodium	Apoptosis , Others , TLR
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...		Apoptosis , Others , TLR
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T23171	Polyinosinic-polycytidylic acid	Poly(I:C)	TLR
	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.		TLR
T38709	PFM39
	PFM39, a Mirin analog, is a potent and selective inhibitor of MRE11 exonuclease activity, specifically targeting the inhibition of phosphate rotation necessary for double-stranded DNA (dsDNA) exonuclease function. Import...
T19836	2-Aminopurine		DNA/RNA Synthesis , PKA
	2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.		DNA/RNA Synthesis , PKA
T8637	DMNB	6-Nitroveratraldehyde	DNA-PK
	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...		DNA-PK
T4434	Tirapazamine	Tirazone,Win59075,SR4233,SR259075	Others
	Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to oth...		Others
T67931	[Tyr3]Octreotate		Others
	[Tyr3]Octreotate is a long peptide compound containing 8 amino acids and is a functional DOTA chelating agent with covalent bonds. [Tyr3]Octreotate binds to transmembrane receptors of SSR2-active NETs and is actively tra...		Others
T19003	HOE-S 785026 trihydrochloride	meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)
	HOE-S 785026 trihydrochloride is a live cell labeling dye that binds nucleic acids by binding to the minor groove in DNA double strands. HOE-S 785026 trihydrochloride tends to bind to A/T-rich DNA strands (fluorescence i...
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak f...
T16283	Neocarzinostatin		5-HT Receptor
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...		5-HT Receptor
T76109	Nuclease S1
	Nuclease S1, a specific endonuclease, degrades single-stranded DNA (ssDNA) and RNA, and can remove protruding single-strand ends from double-stranded DNA [1] [2].
TD0003	CelGreen nucleic acid gel stain 10,000× concentrate in water		Others
	CelGreen nucleic acid gel stain 10,000× concentrate in water is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak ...		Others
T36298	Tyrocidine Complex
	Tyrocidine complex is a mixture of cyclic decapeptides originally isolated from B. brevis. It is active against Gram-positive and Gram-negative bacteria. It forms a complex with single- and double-stranded DNA to inhibit...
T39122	Inclisiran	ALN-PCSsc
	Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (...
T69283	Amikhellin HCl
	Amikhellin HCl, an antimitotic drug, is a synthetic water-soluble derivative of khellin, an alkaloid extracted from seeds of Ammi Visnaga. Amikhellin has been used so far mostly as a vasodiator. Amikhellin binds to doubl...
T38804	Patisiran sodium
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthes...
T76160	Nuclease P1
	Nuclease P1, renowned for its specificity to single-stranded regions within double-stranded nucleic acids, acts as an endonuclease by hydrolyzing nucleic acids into 5'-mononucleotides. Its distinct ability to cleave sing...
T68895	CBP-93872
	CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-speci...
T69024	Homidium Cl
	Homidium Chloride is the chloride salt of ethidium (a fluorochrome), Ethidium Chloride intercalates within double-stranded nucleic acids, particularly DNA. In molecular biology, the bromide salt of ethidium is used to de...
T74248	AS-Inclisiran
	Inclisiran (ALN-PCSsc), a double-stranded small interfering RNA (siRNA) compound, serves as the antisense of itself and targets PCSK-9 transcription inhibition. It is employed in the study of hyperlipidemia and cardiovas...
T79925	T4 UvsX Recombinase		DNA/RNA Synthesis
	T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand. It significantly enhances the snap-back (hairpin-primed) DNA synthesis catalyzed b...		DNA/RNA Synthesis
T69669	Camsirubicin HCl
	Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 inte...
T74876	GalNAc unconjugated/naked Inclisiran
	Inclisiran (unconjugated/naked) is a double-stranded small interfering RNA (siRNA) that lacks GalNAc conjugation. This compound selectively inhibits the transcription of PCSK-9, making it applicable in the research of hy...
T38620	Prexasertib dimesylate	LY2606368 dimesylate
	Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel...
T79923	T7 RNA polymerase		DNA/RNA Synthesis
	T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects on...		DNA/RNA Synthesis
T74249	AS(3n-2)-Inclisiran
	Inclisiran AS(3n-2), an antisense variant of Inclisiran, features a 2 bp spacer followed by 3 random N sites. Inclisiran itself is a double-stranded small interfering RNA (siRNA) molecule designed to suppress PCSK-9 tran...
T83217	Abetimus	LJP 394 free base
	Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering res...
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT is a double-stranded ribonucleoside that is modified with the fluorescent molecule 5'6-FAM, a combination of 5-FAM and 6-FAM. The excitation/emission wavelengths of 5-F...
T82995	Antiviral agent 33
	Antiviral agent 33 (compound 1c), a double-stranded DNA (dsDNA) virus inhibitor, exhibits potent inhibitory activity with IC50 values of 0.0790 µM for VACV and 0.1572 µM for AdV5, and is a candidate for oral administrati...
T4310L2	Prexasertib mesylate	LY-2606368,LY2606368,LY 2606368
	Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a...
T11338	Furamidine	DB75,NSC 305831	Others
	Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...		Others
T35270	YO-Pro 1	YO-Pro1,YO-Pro-1
	YO-Pro 1, a cyanine dye consisting of benzoxazole and quinoline rings connected by a linker, is almost nonfluorescent in water, but its fluorescence is greatly enhanced after intercalation in double-stranded DNA, forming...
T79539	Topoisomerase II inhibitor 16		Topoisomerase
	Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D...		Topoisomerase
T73674	Poly (I:C):Kanamycin (1:1)
	Poly(I:C):Kanamycin (1:1) is a compound comprising an equal mixture of synthetic double-stranded RNA (dsRNA), specifically Poly(I:C), a Toll-like receptor 3 (TLR3) agonist, and kanamycin, a positively charged (poly-NH3) ...
T63152	Prexasertib Mesylate Hydrate
	Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second generation cell cycle detection site kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM). Prexasertib Mesylate Hydrate inhi...
T74052	Polyinosinic-polycytidylic acid potassium
	Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium), a synthetic double-stranded RNA analog, serves as an agonist for toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RIG...
T74067	Poly (I:C):Kanamycin (1:1) (sodium)
	Poly(I:C):Kanamycin (1:1) sodium is a symmetric complex combining Poly(I:C) sodium, a synthetic double-stranded RNA analog acting as a TLR3 and RIG-I/MDA5 agonist, with Kanamycin, an antibacterial agent effective against...

Compounds

Polyinosinic-polycytidylic acid sodium

T12516

Synonym: Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Prexasertib dihydrochloride

T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

Prexasertib

T4310

Synonym: LY2606368

Target: Apoptosis, Chk

Polyinosinic-polycytidylic acid

Target: DNA/RNA Synthesis, PKA

DMNB

T8637

Synonym: 6-Nitroveratraldehyde

Target: DNA-PK

Tirapazamine

T4434

Synonym: Tirazone,Win59075,SR4233,SR259075

HOE-S 785026 trihydrochloride

T19003

Synonym: meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)

Target:

CelGreen nucleic acid gel stain *10,000× concentrate in DMSO*

Target: 5-HT Receptor

CelGreen nucleic acid gel stain *10,000× concentrate in water*

Target: DNA/RNA Synthesis

GalNAc unconjugated/naked Inclisiran

T74876

Synonym:

Target:

Prexasertib dimesylate

T38620

Synonym: LY2606368 dimesylate

Target: DNA/RNA Synthesis

Synonym: LJP 394 free base

Target:

5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT

Synonym: LY-2606368,LY2606368,LY 2606368

Target:

Furamidine

T11338

Synonym: DB75,NSC 305831

Target: Others

YO-Pro 1

T35270

Synonym: YO-Pro1,YO-Pro-1

Target:

Topoisomerase II inhibitor 16

T79539

Synonym:

Target: Topoisomerase

Poly (I:C):Kanamycin (1:1)

T73674

Synonym:

Target:

Prexasertib Mesylate Hydrate

T63152

Synonym:

Target:

Polyinosinic-polycytidylic acid potassium

T74052

Synonym:

Target:

Poly (I:C):Kanamycin (1:1) (sodium)

T74067

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T20041	2'-Deoxyadenosine	NSC-141848,NSC141848,NSC 141848	Endogenous Metabolite
	2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.		Endogenous Metabolite
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
T13592	Calf thymus DNA	DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) is a high-quality double-stranded template DNA extracted from the bovine thymus gland, which can be widely used in the study of DNA binding anticancer agents and ...		DNA/RNA Synthesis
T4809	Pyrimidine	Metadiazine	Others , Endogenous Metabolite
	Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ...		Others , Endogenous Metabolite

天然物製品

2'-Deoxyadenosine

T20041

Synonym: NSC-141848,NSC141848,NSC 141848

Target: Endogenous Metabolite

Irinotecan

T6228

Synonym: CPT-11,Topotecin,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Calf thymus DNA

T13592

Synonym: DNA from calf thymus, Thymonucleic acid

Target: DNA/RNA Synthesis

Pyrimidine

T4809

Synonym: Metadiazine

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPH-01249	ADAR Protein, Human, Recombinant (GST)	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPH-00525	DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc)	Enterobacteria phage T4	E. coli
	May play a role in transcription of several T4 genes. Binds double-stranded DNA and interacts preferentially with T4 late promoter regions.
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His)	Human	Yeast
	IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to v...
TMPJ-01396	PIN4 Protein, Human, Recombinant (His)	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4(PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PA...
TMPK-01253	A35R Protein, Monkeypox virus, Recombinant (His)	Monkeypox virus	HEK293
	Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPJ-00668	HMGB3 Protein, Human, Recombinant (His)	Human	Human Cells
	High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferen...
TMPH-00039	Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)	Agrobacterium fabrum	E. coli
	Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence compos...
TMPK-01123	A29 Protein, Monkeypox virus, Recombinant (His)	Monkeypox virus	E. coli
	Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPK-01250	M1R Protein, Monkeypox virus, Recombinant (His)	Monkeypox virus	HEK293
	Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPH-03184	P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)	Pseudomonas phage phi6	E. coli
	Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them.
TMPH-00848	OASL Protein, Human, Recombinant (His)	Human	E. coli
	Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RN...
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
TMPH-03712	Clp1 Protein, Xenopus laevis, Recombinant (His)	Xenopus laevis	E. coli
	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated mo...
TMPH-01010	BLM Protein, Human, Recombinant (His)	Human	E. coli
	ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwin...
TMPH-02550	BLM Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwin...
TMPH-00577	AlkB Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing...
TMPK-01116	A30 Protein, Monkeypox virus, Recombinant (His)	Monkeypox virus	HEK293
	Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. A30L is an envelope protein required for the fusion of virus and host cell to form s...
TMPH-03193	Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)	Pyrococcus furiosus	E. coli
	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DN...
TMPH-00531	SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)	Enterobacteria phage T7	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-00359	AlkB Protein, Caulobacter vibrioides, Recombinant (His & Myc)	Caulobacter vibrioides	E. coli
	Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing...
TMPH-00532	SSB Protein, Enterobacteria phage T7, Recombinant	Enterobacteria phage T7	Yeast
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPJ-01450	SARS-CoV-2 Helicase Protein (His & MBP)	SARS-CoV-2	E. coli
	The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 ...
TMPH-03470	GyrB Protein, Salmonella typhi, Recombinant (His & Myc)	Salmonella typhi	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favor...
TMPH-00280	PRKRA Protein, Bovine, Recombinant (His & Myc)	Bovine	E. coli
	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and f...
TMPH-00637	RuvA Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a he...
TMPH-02930	TREX1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPJ-00918	HMGB2 Protein, Human, Recombinant (His)	Human	Human Cells
	High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell...
TMPH-02815	Nucleophosmin Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome ...
TMPH-02201	TREX1 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPH-00847	2-5A-dependent Rnase Protein, Human, Recombinant (Myc)	Human	E. coli
	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stran...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-01213	DNASE1L3 Protein, Human, Recombinant (His)	Human	Baculovirus
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01214	DNASE1L3 Protein, Human, Recombinant	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01212	DNASE1L3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01695	MLKL Protein, Human, Recombinant (His)	Human	Yeast
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPH-01344	Flap endonuclease 1/FEN-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displa...
TMPY-04400	TLK2 Protein, Human, Recombinant (aa 397-772, His & GST)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousl...
TMPY-01396	TLR3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental r...
TMPY-04401	TLK2 Protein, Human, Recombinant (aa 397-772)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousl...
TMPY-06410	TLR3 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental r...
TMPH-01239	XPC Protein, Human, Recombinant (His)	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPH-00610	GyrA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa...
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)	ZEBOV	HEK293
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-02877	RIPK3 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggere...
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