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Search Results for " dsRNA "

ターゲット

8

阻害剤

1

天然化合物

14

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T16698 Pyronin Y C.I. 45005,Pyronine G Others
Pyronin Y (Pyronine G) is an intercalating cationic dye that shows specificity towards RNA.
T22698 TLR3-IN-1 CU CPT 4a TLR
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...
T12516 Polyinosinic-polycytidylic acid sodium Poly(I:C) sodium Apoptosis , Others , TLR
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...
T23171 Polyinosinic-polycytidylic acid Poly(I:C) TLR
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.
T73994 Nedosiran sodium
Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.
T39802 Nedosiran DCR-PHXC
Nedosiran (DCR-PHXC) is a GalNAc-dsRNA conjugate designed for RNA interference (RNAi) targeting lactate dehydrogenase (LDH). It serves as a potential therapeutic option for patients with primary hyperoxaluria (PH) and en...
T73674 Poly (I:C):Kanamycin (1:1)
Poly(I:C):Kanamycin (1:1) is a compound comprising an equal mixture of synthetic double-stranded RNA (dsRNA), specifically Poly(I:C), a Toll-like receptor 3 (TLR3) agonist, and kanamycin, a positively charged (poly-NH3) ...
T38234 HCoV-229E-IN-1
HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, demonstrating efficacy with an EC50 value of 0.65 μM in MTS cells and 0.6 μM in CPE cells[1].
カタログ番号 製品名 別名 ターゲット
T9113 Myristicin Myristicine IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-02219 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) H1N1 E. coli
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N...
TMPH-02977 ZNF346 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins. ZNF346 Protein, Mouse, Recombinant (His & SUMO) is expressed in E...
TMPH-01902 DDX60 Protein, Human, Recombinant (His) Human E. coli
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-...
TMPH-03712 Clp1 Protein, Xenopus laevis, Recombinant (His) Xenopus laevis E. coli
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated mo...
TMPH-03404 Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) Reo-3 E. coli
Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase...
TMPH-01247 POLR3K Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs....
TMPY-00323 Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) HCV E. coli
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B...
TMPJ-01429 SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) SARS-CoV-2 E. coli
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and ds...
TMPH-03732 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc) ZEBOV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-03733 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc) ZEBOV HEK293 Cells
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPJ-01427 SARS-CoV-2 NSP7 Protein (His) SARS-CoV-2 E. coli
The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps). The four proteins nsp7 to nsp10, which are...
TMPH-01246 POLR3A Protein, Human, Recombinant (His) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-02133 DDX39B Protein, Human, Recombinant (GST) Human E. coli
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR...
TMPH-01248 ADAR Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
TMPY-02219
Species: H1N1
Expression System: E. coli
ZNF346 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02977
Species: Mouse
Expression System: E. coli
DDX60 Protein, Human, Recombinant (His)
TMPH-01902
Species: Human
Expression System: E. coli
Clp1 Protein, Xenopus laevis, Recombinant (His)
TMPH-03712
Species: Xenopus laevis
Expression System: E. coli
Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)
TMPH-03404
Species: Reo-3
Expression System: E. coli
POLR3K Protein, Human, Recombinant (His)
TMPH-01247
Species: Human
Expression System: Baculovirus Insect Cells
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
TMPY-00323
Species: HCV
Expression System: E. coli
SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)
TMPJ-01429
Species: SARS-CoV-2
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
TMPH-03732
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
TMPH-03733
Species: ZEBOV
Expression System: HEK293 Cells
SARS-CoV-2 NSP7 Protein (His)
TMPJ-01427
Species: SARS-CoV-2
Expression System: E. coli
POLR3A Protein, Human, Recombinant (His)
TMPH-01246
Species: Human
Expression System: E. coli
DDX39B Protein, Human, Recombinant (GST)
TMPH-02133
Species: Human
Expression System: E. coli
ADAR Protein, Human, Recombinant (His & SUMO)
TMPH-01248
Species: Human
Expression System: E. coli