|
T8134 |
Cefathiamidine
|
|
Antibacterial
,
Antibiotic
|
|
Cefathiamidine exhibits a wide spectrum of antimicrobial activity against bacteria. Cefathiamidine is used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis |
|
T8345 |
Carbutamide
|
|
Others
|
|
Carbutamide is a sulfonylurea antidiabetic agent with hypoglycemic activity. |
|
T6451 |
Clodronic acid disodium salt
|
Loron,Clodronate Disodium,Lodronate |
Others
|
|
Clodronic acid disodium salt (Lodronate), a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T0141 |
Cephalonium
|
Cefalonium |
Others
|
|
Cephalonium (Cefalonium) is a first-generation cephalosporin antibiotic. |
|
T0141L |
Cefalonium Dihydrate(5575-21-3 free base)
|
Cefalonium Dihydrate |
Others
|
|
Cefalonium Dihydrate(5575-21-3 free base) is a first-generation cephalosporin antibiotic. |
|
T0371 |
Gliquidone
|
AR-DF 26,Glurenorm |
Potassium Channel
|
|
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared... |
|
T9225 |
Vebicorvir
|
ABI-H0731 |
HBV
|
|
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. |
|
T8457 |
NPS2390
|
|
GluR
|
|
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively) |
|
T0092 |
Antazoline hydrochloride
|
Phenazocine HCl,Phenazoline hydrochloride,Antazoline HCl |
Histamine Receptor
|
|
Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine. |
|
T61042 |
TBT1
|
|
|
|
TBT1 is a MsbA ATPase stimulator and an LPS transport inhibitor in Acinetobacter strains. The EC50 value of TBT1 stimulated ATPase activity is 13 μM. TBT1 is a first-generation inhibitor of the MsbA transporter [1]. |
|
T7941 |
Imipramine hydrochloride
|
Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine |
Serotonin Transporter
|
|
Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd... |
|
T21419 |
Diphenhydramine
|
Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255 |
Histamine Receptor
|
|
Diphenhydramine (Syntedril), a first-generation antihistamine possessing antiemetic, antitussive, anticholinergic, and sedative properties, is mainly used in the treatment of allergies. Diphenhydramine is also used in th... |
|
T0445L |
Promethazine hydrochloride
|
Promethazine HCl,Phenergan |
Adrenergic Receptor
,
Histamine Receptor
|
|
Promethazine hydrochloride (Promethazine HCl) , the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-HT2A, 5-HT2C, D2 and α... |
|
T0199 |
Cephradine
|
Anspor,Cephradin,Velosef,SQ-11436,Sefril |
TOPK
,
Antibacterial
,
Antibiotic
|
|
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. |
|
T2551 |
Etravirine
|
TMC125,R165335 |
HIV Protease
,
Reverse Transcriptase
|
|
Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribe... |
|
T16472 |
Pericyazine
|
Propericiazine,RP 8909 |
Dopamine Receptor
|
|
Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych... |
|
T0059 |
Diphenylpyraline hydrochloride
|
4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor
|
|
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine re... |
|
T21390 |
Fexofenadine
|
Carboxyterfenadine,Telfast,MDL 16.455,Allegra |
Histamine Receptor
|
|
Fexofenadine (Carboxyterfenadine), an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is... |
|
T0816 |
Acetohexamide
|
Acetohexamid,Dymelor,Gamadiabet |
Potassium Channel
,
NADPH
|
|
Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) wi... |
|
T0953 |
Cefazolin sodium
|
Ancef,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin |
Others
,
Antibacterial
,
Antibiotic
|
|
Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta... |
|
T1122 |
Cephalothin sodium
|
Cefalotin sodium,Cephalothin,Cefalotin |
Antibacterial
,
Antibiotic
|
|
Cephalothin sodium (Cefalotin) binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cephalothin sodium (Cefalotin) is the sodium salt form of cephalothin, a... |
|
T20616 |
Coumachlor
|
G-23133,Ratilan,G23133,Tomorin,G 23133 |
|
|
Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage. |
|
T68967 |
AFG206
|
|
|
|
AFG206 is the novel first-generation type II" FLT3 inhibitor." |
|
T33319 |
Methdilazine Hydrochloride
|
Bristaline,Dilosyn,Methdilazine Hcl,Tacaryl hydrochloride,Disyncran |
|
|
Methdilazine Hydrochloride is a first-generation phenothiazine class antihistamine with anticholinergic properties. |
|
T32233 |
Isothipendyl
|
Udantol,Isothipendylum,Odantol,Andanton,Nilergex |
|
|
Isothipendyl is the first generation of H1 antagonists (antihistamines) and anticholinergics and has an effect on itching. |
|
T70308 |
PLX7683
|
|
|
|
PLX7683 is a paradox breaker. Paradox breakers overcame several known mechanisms of resistance to first-generation RAF inhibitors. Dissociating MAPK pathway inhibition from paradoxical activation might yield both impro... |
|
T0445L1 |
Promethazine hibenzate
|
D-08768,D08768,D 08768 |
|
|
Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. |
|
T0059L |
Diphenylpyraline
|
Difenilpiralina,AN 1041,AN1041,Dayfen,AN-1041 |
|
|
Diphenylpyridine is the first generation antihistamine, which has the anticholinergic effect of diphenylpiperidine. |
|
T71117 |
AZD5248
|
|
|
|
AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1). |
|
T14929 |
Cephradine monohydrate
|
Cefradine monohydrate |
Antibacterial
|
|
Cephradine monohydrate, a first-generation cephalosporin, is active against a wide range of Gram-positive and Gram-negative bacteria. |
|
T69702 |
AFG210
|
|
|
|
AFG210 is a novel first-generation “type II” FLT3 inhibitor. |
|
T38972 |
Cefalonium hydrate
|
|
|
|
Cefalonium hydrate is a first-generation β-lactam cephalosporin antibiotic commonly employed in the study of bovine mastitis induced by Gram-positive bacteria, particularly staphylococci. It demonstrates significant effe... |
|
T38918 |
Revusiran
|
ALN-TTRSC |
|
|
Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research. |
|
T40591 |
Verapamil EP Impurity C hydrochloride
|
NSC-609249 hydrochloride |
|
|
NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor. |
|
T14040 |
4-Hydroxytolbutamide
|
Hydroxytolbutamide |
Potassium Channel
|
|
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2]. |
|
T32700 |
Levocabastine
|
Livostin,Bilina |
|
|
Levocarbastine is a second-generation H1 receptor antagonist for allergic conjunctivitis. It also acts as a potent selective antagonist for the neurotensin receptor NTS2 and is the first drug to be used to characterize d... |
|
T19979 |
Saccharin sodium hydrate
|
O-benzoic sulfimide sodium salt,Saccharin, sodium salt hydrate |
|
|
Saccharin, sodium salt hydrate is used in the food industry and for sweetening diabetes diet. It is also used as a synthetic sweet ignorance agent. Saccharin, sodium salt hydrate is the first generation′ synthetic sugar ... |
|
T19678 |
Cefaloridine
|
Cephaloridine,Sch 11527 |
|
|
Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has... |
|
T36212 |
16(S)-Iloprost
|
|
|
|
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to ... |
|
TP2288 |
Rapalink-1
|
|
Others
|
|
RapaLink-1 is the third-generation mTOR inhibitor exploiting the unique juxtaposition of two drugs (first- and second-generation mTOR kinase inhibitors) -binding pockets to create a bivalent interaction that allows inhib... |
|
T36211 |
16(R)-Iloprost
|
|
|
|
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to ... |
|
T71577 |
KOS-1584
|
|
|
|
KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which m... |
|
T0366L |
Cefadroxil (hydrate)
|
|
|
|
Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate... |
|
T35619 |
Dapagliflozin-3-O-β-D-Glucuronide
|
|
|
|
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metab... |
|
T75300 |
Cefazolin sodium pentahydrate
|
|
|
|
Cefazolin sodium pentahydrate, a first-generation cephalosporin antibiotic, is employed in diverse bacterial infection research [1] and exhibits an anti-inflammatory effect capable of attenuating post-operative cognitive... |
|
T69925 |
NVR3-778 hydrate
|
|
|
|
NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus part... |
|
T71110 |
Nanatinostat TFA
|
|
|
|
Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inh... |
|
T70287 |
BMS-186511
|
|
|
|
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from m... |
|
T36175 |
AAPH
|
|
|
|
AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.[1],[2],[3],[4] Decomposition of AAPH produces... |
