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T2026 |
CYM5442
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S1P Receptor
,
LPL Receptor
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CYM5442 is an S1P agonist, targeting to Sphingosine. |
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T7748 |
Dermorphin TFA
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Others
,
Opioid Receptor
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Dermorphin TFA is a new class of opioids-like peptides |
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T22733 |
DL-AP5
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NMDAR
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DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects. |
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T7404 |
Dermorphin
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Opioid Receptor
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Dermorphin is agonist of μ-opioid receptor (MOR) agonist. |
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T5913 |
Sulbutiamine
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Bisibuthiamine |
Antioxidant
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Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death. |
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TP1283L |
VIP(6-28)(human, rat, porcine, bovine) acetate
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Others
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T72662 |
NMDAR/TRPM4-IN-2
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ERK
,
TRP/TRPV Channel
,
NMDAR
,
iGluR
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NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot... |
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T28431 |
PNU109291
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PNU-109291,PNU 109291 |
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PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation. |
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T3289L |
Amifostine Hydrate
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Amifostine Hydrate is a radiation protective agent that induces splenic vasodilation and blocks autonomic ganglion. |
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TP2393 |
Neurotensin-related hexapeptide
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Lant-6 |
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Neurotensin-related hexapeptide exists in retinal ganglion cells and in their central projections in pigeons and may be utilized as a neuroactive substance by the central terminals of numerous retinal ganglion cells in b... |
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TP1934 |
L-R4W2
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Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo. |
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T28987 |
TN-871 HCl
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TN-871 dihydrochloride,TN871,TN 871,TN-871 |
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TN-871 is a potassium and calcium channel antagonist. TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh. |
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T16135 |
MRS 1523
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Others
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MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 recept... |
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T68811 |
Trimetaphan camsilate
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Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathe... |
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T80443 |
ω-Conotoxin MVIID
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SNX-238 |
Calcium Channel
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ω-Conotoxin MVIID (SNX-238) is a peptide from the Conus genus that inhibits the ω-Conotoxin-GVIA-sensitive, high-threshold calcium (Ca 2+) current in fish retinal ganglion cells [1]. |
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T25110 |
AS1069562
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AS-1069562,AS 1069562 |
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AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake which acts by notably restoring reduced insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and s... |
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TP2070 |
BDS I
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Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal ro... |
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T37296 |
GI-530159
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|
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TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane pot... |
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T35889 |
PB2
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PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficac... |
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T37086 |
PDDHV
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PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It i... |
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T79246 |
6-Iodoamiloride
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Sodium Channel
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6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM. It also effectively inhibits ASIC3-mediated currents in rat dorsal root ganglion neurons, with an IC50 of 23... |
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T80428 |
Jingzhaotoxin-34
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Sodium Channel
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Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neurons with an IC50 of approximately 85 nM and exerts negligible inf... |
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T80455 |
ω-Conotoxin CVIB
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Sodium Channel
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ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs). It inhibits depolarization-activated whole-cell VGCC currents in dorsal root ganglion (DRG) neurons, exhibiting a... |
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T37201 |
CAY10787
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CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing α1β1γ2or α4β3γ2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 μM, respectiv... |
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T35888 |
PB1
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PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable st... |
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T80495 |
MHuwentoxin-IV
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Sodium Channel
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mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in dorsal root ganglion neurons with an IC50 value of 54.16 nM. Notably, the i... |
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T80421 |
CSD-CH2(1,8)-NH2
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Opioid Receptor
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CSD-CH2(1,8)-NH2 is a selective and competitive kappa-opioid receptor (KOR) antagonist with a K i of 6.8 nM. It inhibits calcium mobilization in dorsal root ganglion (DRG) neurons and antagonizes the antinociceptive effe... |
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T80186 |
Hainantoxin-III
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Sodium Channel
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Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting both tetrodotoxin-resistant and tetrodotoxin-sensitive sodium curren... |
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T80066 |
ShK toxin
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Potassium Channel
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ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel). It competes with dendrotoxin I and α-dendrotoxin in binding to ra... |
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T80425 |
Jingzhaotoxin-V
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Sodium Channel
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Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons, with IC50 val... |
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T83739 |
Myr-Tat-CBD3 TFA
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Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3 |
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Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound ... |
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T83728 |
Tat-AKAP79 (326-336) TFA
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Tat-A-kinase Anchor Protein 79 (326-336) |
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Tat-AKAP79 (326-336) is a peptide that links the HIV-1 Tat protein transduction domain with an 11-amino acid sequence from A-kinase anchor protein 79 (AKAP79). This compound effectively inhibits the activation-induced se... |
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T83731 |
Tat-CBD3 TFA
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Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
