|
T5033 |
Olprinone
|
Loprinone |
PDE
|
|
Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ... |
|
T1265 |
Amrinone
|
Inamrinone,Inocor,Wincoram |
TNF
,
PDE
|
|
Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity. |
|
T15050 |
Danicamtiv
|
MYK-491,SAR 440181 |
Myosin
|
|
Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. |
|
T1320 |
Disopyramide
|
Triombrin,Hypaque sodium,amidotrizoate sodium |
Potassium Channel
,
Sodium Channel
,
AChR
|
|
Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h... |
|
T3465 |
Vesnarinone
|
OPC-8212,Arkin,Piteranometozine |
HIV Protease
,
PDE
|
|
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel... |
|
T33806 |
Opc 18750
|
Opc18750,Opc-18750 |
Others
|
|
Opc 18750 is a compound with selective and positive inotropic effects. |
|
T33589 |
Nanterinone
|
UK-61260,UK61260,UK 61260 |
PDE
|
|
Nanterinone (UK 61260), an orally available partial phosphodiesterase inhibitor, is a novel positive inotropic and balanced vasodilator compound.Nanterinone, when administered orally, results in significant improvements ... |
|
T21457 |
Carbazeran
|
UK-31557,UK31,557,UK-31,557,UK31557,UK 31557,UK 31,557 |
PDE
|
|
Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM). |
|
T83974 |
OPC18750 HCl
|
|
PDE
|
|
OPC18750 HCl is a potential phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders. |
|
T71744 |
Imazodan
|
|
PDE
|
|
Imazodan, a small molecule compound with positive inotropic activity, is a selective type III phosphodiesterase inhibitor and can be used to study heart failure. |
|
T14507 |
Bay 60-7550
|
BAY 607550 |
PDE
|
|
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem... |
|
TP2044L |
α-CGRP (human) acetate
|
α-CGRP (human) acetate (90954-53-3 free base) |
Others
|
|
α-CGRP (human) acetate is a regulatory neuropeptide of 37 amino acids. It is the most potent vasodilator known to date and has inotropic and chronotropic effects. |
|
T25984 |
(±)-Prenalterol
|
H80/62,H-80/62,H 80/62 |
Adrenergic Receptor
|
|
(±)-Prenalterol (H 80/62) is a new cardioselective positive inotropic compound that is an agonist of beta-2- and beta-1-adrenergic receptors and can be used to study chronic congestive heart failure. |
|
T27205 |
DPI 201-106
|
DPI-201-106 |
Sodium Channel
|
|
DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents. |
|
T3465L |
Vesnarinone HCl
|
Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base) |
Potassium Channel
,
Calcium Channel
,
PDE
|
|
Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new... |
|
T0871 |
Noradrenaline bitartrate
|
|
Adrenergic Receptor
|
|
Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... |
|
T32829 |
Lnd 623
|
Lnd-623,Lnd623 |
|
|
Lnd 623 is an inotropic aminosteroid. |
|
T30286 |
BA 41899
|
BA41899,BA-41899 |
|
|
BA 41899 is a positive inotropic Ca(2+)-sensitizing agent. |
|
T33807 |
Opc 8490
|
Opc-8490,Opc8490 |
|
|
Opc 8490 is a positive inotropic agent. |
|
T27833 |
Liguzinediol
|
|
|
|
Liguzinediol, a potent positive inotropic agent, inhibits myocardial cell apoptosis. |
|
T32997 |
LY 249933
|
LY249933,LY-249933 |
|
|
LY 249933 is a cardioselective 1, 4-dihydropyridine with positive inotropic activity. |
|
T15714 |
LAS-31180
|
|
Others
|
|
LAS-31180 is a phosphodiesterase 3 inhibitor. It also has positive inotropic and vasodilator properties. |
|
T33805 |
OPC 18692
|
OPC-18692,OPC18692 |
|
|
OPC 18692 is a metabolite of Vesnarinone, a positive inotropic drug developed for congestive heart failure. |
|
T30197 |
ATI-22-107
|
ATI22-107 |
|
|
ATI-22-107 is a positive cardiac inotropic agent which may affect myocyte calcium cycling and contractility. |
|
T33589L |
Nanterinone mesylate
|
UK61260,UK-61260,UK 61260 |
|
|
Nanterinone Mesylate is the mesylate form of Nanterinone that is a novel positive inotropic and balanced vasodilator. |
|
T30956 |
CK 3197
|
CK3197,CK-3197 |
|
|
CK 3197 is a selective positive inotropic agent for the treatment of congestive heart failure. It has hemodynamic and myocardial energetic effects. |
|
T68782 |
Ono 11006
|
|
|
|
Ono 11006 is a thromboxane agonist that dose dependently reduced the positive inotropic effect induced by field stimulation. |
|
T71122 |
Carsatrin (free base)
|
|
|
|
Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle... |
|
T68742 |
Inamrinone lactate
|
|
|
|
Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. |
|
T11609 |
ICI 153110
|
|
Others
|
|
|
|
T21424 |
Disopyramide phosphate
|
SC13957,SC 13957,SC-13957 |
|
|
Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting ... |
|
T16769 |
Ro 363
|
|
Adrenergic Receptor
|
|
RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-ad... |
|
T70975 |
Carsatrin succinate
|
|
|
|
Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action ... |
|
T80461 |
Anthopleurin-C
|
|
Sodium Channel
|
|
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide exhibiting a potent positive inotropic effect [1]. |
|
T69239 |
Nylidrin
|
|
|
|
Nylidrin is a beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and... |
|
T14967 |
Cimlanod
|
BMS-986231,CXL-1427 |
Others
|
|
Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the... |
|
T69107 |
Doxaminol
|
|
|
|
Doxaminol is a synthetic partial beta-adrenergic agonist with sympathomimetic activity. Doxaminol may bind to and stimulate beta-1-adrenergic receptors located in the myocardium. As a result, it leads to a positive inotr... |
|
T69000 |
Prenalterol hydrochloride
|
|
|
|
Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output ... |
|
T68600 |
Enoximone sulfoxide
|
|
|
|
Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation... |
|
T69085 |
Mabuterol, (S)-
|
|
|
|
Mabuterol, (S)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. M... |
|
T69084 |
Mabuterol, (R)-
|
|
|
|
Mabuterol, (R)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. M... |
|
T68242 |
D-Mabuterol hydrochloride
|
|
|
|
D-Mabuterol hydrochloride is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guin... |
|
TP2000 |
MM 07
|
|
|
|
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in... |
|
T27970 |
Mabuterol free base
|
Mabuterol,PB 868Cl |
Others
|
|
Mabuterol is a selective agonist of β2 adrenoreceptor with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6)... |
|
T61918 |
Ro 363 hydrochloride
|
|
|
|
Ro 363 hydrochloride is an effective, highly selective agonist of β 1-adrenoceptor. Ro 363 hydrochloride is an effective inotropic stimulant. Ro 363 hydrochloride is a cardiovascular regulator, which can reduce diastolic... |
|
T28618 |
RS-93522
|
RS 93522 |
|
|
RS-93522 is an antagonist of calcium channel. RS-93522 had the additional property of inhibiting phosphodiesterase activity in myocardial homogenates (IC50 = 1.6 x 10(-5)M), the potency and efficacy of phosphodiesterase ... |
|
TP1885 |
[(pF)Phe4]Nociceptin(1-13)NH2
|
|
|
|
Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronocicep... |
|
T69119 |
Disopyramide HCl
|
|
|
|
Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agen... |
|
T69975 |
Istaroxime oxalate
|
|
|
|
Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular... |
|
T36547 |
Quazinone
|
|
|
|
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Qua... |
