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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T9407	Rasarfin		Others , Ras
	Rasarfin inhibits Ras and ARF6.		Others , Ras
T2026	CYM5442		S1P Receptor , LPL Receptor
	CYM5442 is an S1P agonist, targeting to Sphingosine.		S1P Receptor , LPL Receptor
TP1923L1	ELA-14(human) acetate	ELA-14(human) acetate (1886973-05-2 free base)	Apelin receptor , Arrestin
	ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.		Apelin receptor , Arrestin
TP1944L1	Pep2-SVKI acetate	pep2-SVKI acetate(328944-75-8 free base)	GluR
	Pep2-SVKI acetate(pep2-SVKI acetate (328944-75-8 free base)) is a synthetic peptide salt that prevents internalization of AMPA-type glutamate receptor.		GluR
T7026L	Kukoamine B mesylate		Antioxidant
	Kukoamine B mesylate is a novel cationic alkaloid derived from dermatophytes with antioxidant activity, inhibits LPS internalization in Kupffer and RAW 264.7 cells, and can be used to study acute inflammation and diabete...		Antioxidant
T12269	NUCC-390		CXCR
	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodeg...		CXCR
T77149	Cobolimab	TSR-022,GSK4069889	Others
	Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic mela...		Others
T10242	ACT-389949		Others
	ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of...		Others
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T4031	S1p receptor agonist 1	S1p-receptor-agonist-1	S1P Receptor , LPL Receptor
	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.		S1P Receptor , LPL Receptor
T9169	MPP+ iodide		Mitochondrial Metabolism , Autophagy
	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...		Mitochondrial Metabolism , Autophagy
TP1907	DynaMin inhibitory peptide, myristoylated
	Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
TP1840	Antennapedia Peptide
	Antennapedia Peptide is a 16 amino acid peptide corresponding to the region within the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization.
T73665	Bufrolin
	Bufrolin, an analog of Cromoglycate (histamine release inhibitor) and a potent agonist of GPR35, enhances the interaction between β-arrestin-2 and both human GPR35a and rat GPR35. It stabilizes mast cells, exhibiting ant...
T82596	Deac-SS-Biotin
	Deac-SS-Biotin is a potent antitumor compound that enters cells via biotin-mediated internalization. When combined with DTT (Glutathione mimetic), it effectively inhibits microtubule assembly and exhibits enhanced antitu...
T81449	PKC-ε translocation inhibitor peptide		PKC
	PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαR trafficking [1].		PKC
T36634	ZQ 16
	Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK...
T76375	Targefrin
	Targefrin is a potent antagonist targeting EphA2, exhibiting a dissociation constant of 21 nM and an IC50 value of 10.8 nM for the EphA2-LBD. It promotes receptor internalization and degradation across multiple pancreati...
T74940	Anticancer agent 81		Apoptosis
	Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the antibody-agent conjugate (ADC) T-PBA. T-PBA retains the targeti...		Apoptosis
T78462	C6 NBD Glucosylceramide
	C6 NBD Glucosylceramide, a fluorescent derivative of glucosylceramide (Ex=466 nm, Em=535 nm), is utilized to investigate glucosylceramide metabolism and internalization, as well as to assess glucosylceramide synthase act...
T76072L	CCZ01048 TFA
	CCZ01048 TFA, an α-MSH analogue, demonstrates a strong binding affinity for the melanocortin 1 receptor (MC1R), displaying a K i value of 0.31 nM. It exhibits rapid internalization into B16F10 melanoma cells and maintain...
T76854	Loncastuximab tesirine
	Loncastuximab tesirine, a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC), binds to CD19 on the cell membrane, facilitating rapid internalization and inducing cell apoptosis. This mechan...
T82239	HAP-1
	HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form...
T63004	NUCC-390 dihydrochloride
	NUCC-390 dihydrochloride, a novel and selective CXCR4 receptor agonist, effectively induces the internalization of CXCR4 receptors and acts antagonistically to AMD3100 [1]. This small-molecule compound has demonstrated t...
T63661	HF51116
	HF51116 is a potent antagonist of XCR4. HF51116 significantly antagonizes SDF-1α-induced cell migration, calcium mobilization and CXCR4 internalization, and inhibits HIV-1 infection using CXCR4. HF51116 has shown investi...
T78279	Cixutumumab	NSC742460,IMC-A12
	Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding downstream signaling. Additionally, it facilitates the internali...
T38339	R-8507
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, resp...
T76044	Elabela(19-32) TFA
	Elabela(19-32) TFA, an effective fragment of ELABELA (ELA), selectively engages with the apelin receptor (APJ). This compound initiates G αi1 and β-arrestin-2 signaling, demonstrating EC50 values of 8.6 nM and 166 nM, re...
T81773	Modotuximab	Sym 004,DS 1024
	Modotuximab (Anti-Human EGFR Recombinant Antibody), an IgG1κ-type chimeric antibody, selectively binds to human EGFR protein. Incorporating elements from Futuximab, it targets two distinct, non-overlapping epitopes on EG...
T68232	Epofolate
	Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated th...
T72721	PD-1/PD-L1-IN-29
	PD-1/PD-L1-IN-29 (S4-1) is a potent inhibitor of the PD-1/PD-L1 interaction, with an IC50 value of 6.1 nM. It effectively binds to PD-L1, inhibiting the PD-1/PD-L1 interaction, promotes PD-L1 dimerization and its interna...
T83926	S-Geranylgeranyl-L-glutathione	GGG
	S-Geranylgeranyl-L-glutathione acts as a ligand for the orphan G protein-coupled receptor (GPCR) P2RY8, displaying selective affinity by inducing internalization of P2RY8 in preference to the sphingosine-1-phosphate rece...
T83964	Tri-GalNAc-PEG3-Azide
	Tri-GalNAc-PEG3-Azide is a specialized compound designed for lysosomal targeting chimera (LYTAC) research, featuring three asialoglycoprotein receptor (ASGPR) ligands linked by a PEG3 spacer and an azide group for easy c...
T75134	MC-GGFG-AM-(10Me-11F-Camptothecin)
	MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits...
T83763	EPI-X4 TFA	Endogenous Peptide Inhibitor of CXCR4
	EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor in...
T83906	Tirzepatide sodium	LY3298176
	Tirzepatide acts as an agonist for both the glucagon-like peptide 1 receptor (GLP-1R) and G protein-coupled receptor 119 (GPR119), effectively inducing cAMP production in HEK293 cells that express either human GLP-1R or ...

Compounds

Target: S1P Receptor, LPL Receptor

ELA-14(human) acetate

TP1923L1

Synonym: ELA-14(human) acetate (1886973-05-2 free base)

Target: Apelin receptor, Arrestin

pep2-SVKI acetate

TP1944L1

Synonym: pep2-SVKI acetate(328944-75-8 free base)

Synonym: TSR-022,GSK4069889

Target: S1P Receptor, LPL Receptor

S1p receptor agonist 1

T4031

Synonym: S1p-receptor-agonist-1

Target: S1P Receptor, LPL Receptor

MPP+ iodide

T9169

Synonym:

Target: Mitochondrial Metabolism, Autophagy

DynaMin inhibitory peptide, myristoylated

PKC-ε translocation inhibitor peptide

C6 NBD Glucosylceramide

Loncastuximab tesirine

NUCC-390 dihydrochloride

Synonym: NSC742460,IMC-A12

Synonym: Sym 004,DS 1024

S-Geranylgeranyl-L-glutathione

T83926

Synonym: GGG

Target:

tri-GalNAc-PEG3-Azide

T83964

Synonym:

Target:

MC-GGFG-AM-(10Me-11F-Camptothecin)

T75134

Synonym:

Target:

RWJ-56110 dihydrochloride

Synonym: Endogenous Peptide Inhibitor of CXCR4

カタログ番号	製品名	別名	ターゲット
T13126	Tephrosin	Deguelinol I,Hydroxydeguelin	Others
	Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.		Others
TN5580	Rediocide A
	Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediate...

天然物製品

Tephrosin

T13126

Synonym: Deguelinol I,Hydroxydeguelin

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01447	Apolipoprotein B-100/APOB Protein, Human, Recombinant (His)	Human	E. coli
	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles ...
TMPH-00963	Ataxin-2 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Ataxin-2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. ...
TMPH-02437	5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	HEK293 Cells
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK2...
TMPH-02267	AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decr...
TMPH-03392	5T4/TPBG Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli ex...
TMPH-02436	5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)	Cynomolgus	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expresse...
TMPK-00418	MERTK/Mer Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-00632	MD2/LY96 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocy...
TMPH-02253	TPM2 Protein, Human, Recombinant (His)	Human	E. coli
	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra...
TMPK-01022	MERTK/Mer Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-00694	CD1A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD1 proteins are a family of major histocompatibility complex (MHC) class I-like antigen-presenting molecules that present lipids to T cells. The cytoplasmic tails (CTs) of all human CD1 isoforms, with the exception of C...
TMPH-03561	LsdB Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays i...
TMPK-00879	CCR2b Protein-VLP, Human, Recombinant	Human	HEK293 Cells
	The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammator...
TMPK-01242	MD2/LY96 Protein, Human, Recombinant (His)	Human	E. coli
	MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocy...
TMPK-00115	CD79B Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal tran...
TMPH-03385	Thyroglobulin Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by ...
TMPJ-00805	Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and ca...
TMPK-00417	MERTK/Mer Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPJ-00678	STX6 Protein, Human, Recombinant	Human	E. coli
	Syntaxin-6 (STX6) is a single-pass type IV membrane protein, which belongs to the Syntaxin family. STX6 is mainly localized in the plasma membrane. STX6 contains one t-SNARE coiled-coil homology domain and involved in in...
TMPH-03036	Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc)	Naja atra	E. coli
	Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a modera...
TMPJ-00394	LDLR Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repe...
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c...
TMPH-01223	DKK2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in...
TMPJ-00156	DKK1 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 inter...
TMPH-02345	Influenza A H1N1 (train A/Hickox/1940) Hemagglutinin/HA Protein (His & SUMO)	H1N1	E. coli
	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis...
TMPJ-00526	Langerin/CD207 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the e...
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un...
TMPJ-00831	CCL3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, ...
TMPY-01692	NETO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...
TMPY-00990	Lefty-A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamil...
TMPJ-00952	CXCL12 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, an...