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T16156 |
MT 63-78
|
|
Apoptosis
,
AMPK
,
mTOR
|
|
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel... |
|
T1801 |
SR9243
|
|
Liver X Receptor
|
|
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. |
|
T11661 |
INT-767
|
|
FXR
,
GPCR19
|
|
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis. |
|
T8760 |
NNMTi
|
5-Amino-1-methylquinolinium |
Others
|
|
NNMTi (5-Amino-1-methylquinolinium) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adip... |
|
T82240 |
Haloxyfop-P-methyl
|
|
|
|
Haloxyfop-P-methyl, an aryloxyphenoxypropionate herbicide, is absorbed through both foliage and roots, where it inhibits lipogenesis and induces oxidative stress in susceptible plant species [1]. |
|
T74147 |
Larsucosterol (trimethylamine)
|
|
|
|
Larsucosterol (DUR-928) trimethylamine, a metabolite of cholesterol, functions as a powerful liver X receptor (LXR) antagonist, effectively reducing lipogenesis and inhibiting cholesterol biosynthesis. It achieves this b... |
|
T78873 |
CTL-12
|
|
|
|
CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apo... |
|
T78872 |
CTL-06
|
|
|
|
CTL-06, a Fatty Acid Synthase (FASN) inhibitor with an IC50 of 3 μM, induces apoptosis, while CTL-12 impedes cell cycle progression in the Sub-G1/S phase and modulates apoptotic and anti-apoptotic markers by upregulating... |
|
T37522 |
Teneligliptin
|
|
|
|
Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
Teneli... |
