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T38910 |
mGluR2 antagonist 1
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mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ... |
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T62202 |
mGluR2 modulator 1
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mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p... |
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T60882 |
mGluR2 modulator 2
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mGluR2 modulator 2 (compound 2) can be used in antipsychotic research. mGluR2 modulator 2 is a potent, selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC 50 value of 0.13 μM [1]. |
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T61277 |
mGluR2 modulator 4
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mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1]. |
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T15090 |
Decoglurant
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RO4995819 |
GluR
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Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant. |
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T10432L |
AZD-8529 mesylate
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GluR
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AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ... |
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T3479 |
(RS)-MCPG
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alpha-MCPG,(±)-MCPG |
GluR
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(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist. |
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T27932 |
LY-2300559
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LY2300559 |
GluR
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LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine. |
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T15812 |
LY2979165
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mGlu2 agonist |
GluR
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LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant. |
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T3464 |
PHCCC
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(-) PHCCC |
GluR
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PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8. |
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T3484 |
Trans-ACPD
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Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD |
GluR
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trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/1... |
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T41301 |
L-Cysteinesulfinic acid monohydrate
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GluR
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L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectiv... |
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T6022 |
LY404039
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pomaglumetad |
Glucocorticoid Receptor
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GluR
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LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). |
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T27942 |
LY307452
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LY 307452,LY-307452 |
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LY307452 is a selective antagonist of mGluR2/3. |
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T10432 |
AZD-8529
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Others
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AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. |
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T23294 |
(S)-4C3HPG
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Others
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group I mGlu1a/1a receptor antagonist and mGluR2 agonist |
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T9353 |
OXOMEMAZINE
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AChR
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Histamine Receptor
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Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... |
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T27449 |
GSK1331268
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GSK 1331268,GSK-1331268 |
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GSK1331268 is a selective, orally bioavailable positive modulators of mGluR2. |
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T27448 |
GSK1331258
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GSK 1331258,GSK-1331258 |
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GSK1331258 is a selective, orally bioavailable positive modulators of mGluR2. |
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T14615 |
Biphenylindanone A
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BINA |
GluR
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Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders. |
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T79302 |
MK-8768
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MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by excellent brain permeability. |
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T28600 |
Ro4491533
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Ro 4491533,Ro-4491533 |
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Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3). |
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T60611 |
Talaglumetad hydrochloride
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Talaglumetad hydrochloride is a prodrug of Eglumegad which is the potent and selective agonist of the type II metabotropic glutamate receptor (mGluR2/3) to treat with psychiatric disorders. |
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T28034 |
MGS-0039
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BCI 632,BCI-632,MGS0039,BCI632 |
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MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor... |
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T62756 |
LY487379
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LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). lY487379 enhances glutamate-stimulated [35 S] GTPγS binding to mGlu2 receptors (EC50: 1.7 μM) and mGlu3 receptors (EC50>10 μM). lY487379 induces c... |
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T15816 |
LY341495
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GluR
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LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders. |
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T3486 |
3-MATIDA
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GluR
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NMDAR
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3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3... |
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T23515 |
VU-29
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VU 29 |
GluR
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VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM). |
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T15618 |
JNJ-46281222
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GluR
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JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71). |
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T11165 |
EGLU
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(2S)-α-EGLU,(2S)-α-Ethylglutamic acid |
Others
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EGLU, also known as (2S)-α-Ethylglutamic acid or (2S)-α-EGLU, is a potent and competitive antagonist of the mGluR-2 receptor, demonstrating a Kd value of 66 μM when interacting with the (lS,3S)-ACPD-sensitive site. This ... |
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T15807 |
LY2794193
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SGLT
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LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM). |
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T11906 |
LY 541850
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GluR
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LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expres... |
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T15809 |
LY2812223
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LIM Kinase
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LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). |
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T11911 |
LY3020371 hydrochloride
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GluR
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T38791 |
LY3020371
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LY3020371 is a highly potent and selective antagonist targeting the glutamate (mGlu) 2/3 receptor, showcasing excellent inhibition at Ki values of 5.26 nM and 2.50 nM for hmGluR2 and hmGluR3, respectively. With its remar... |
