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T8995 |
NCGC00262650
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|
Others
,
Src
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NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity. |
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T26889 |
Borofalan(10B)
|
L-4-Boronophenylalanine |
Others
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|
Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer. |
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T0091 |
Alfuzosin hydrochloride
|
SL 77499-10,Alfuzosin HCl |
Adrenergic Receptor
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Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH). |
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T17035 |
Temoporfin
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Others
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Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. |
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T76696 |
Onvatilimab
|
JNJ-61610588 |
Others
|
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Onvatilimab (JNJ-61610588) is a human IgG1 κ-anti-Vista (T-cell-activated V-domain Ig inhibitor) monoclonal antibody. Onvatilimab has antitumor activity and can be used to treat advanced head and neck cancers. |
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T2618 |
LGK974
|
LGK 974,LGK-974,NVP-LGK974,WNT974 |
Porcupine
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|
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel... |
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T9175 |
Casein Kinase inhibitor A51
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|
Apoptosis
,
Casein Kinase
|
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Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, b... |
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T77423 |
Lirilumab
|
ONO-4483,IPH2102 |
Virus Protease
|
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Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-depende... |
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T76890 |
Petosemtamab
|
MCLA 158 |
EGFR
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|
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab... |
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T76691 |
Monalizumab
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|
IFNAR
,
Chk
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|
Monalizumab is a novel immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized monoclonal antibody against NKG2A that induces IFN-γ production, thereby activating natur... |
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T0210L |
Tamsulosin
|
LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744 |
Adrenergic Receptor
|
|
Tamsulosin ((R)-(-)-YM12617 free base) is an alpha1A adrenergic receptor antagonist for the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin is used to treat difficulty urinating, a common symptom ... |
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T71912 |
PD 173955-Analog1
|
|
|
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PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma. |
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T29965 |
Amethopterin
|
DL-Amethopterin |
|
|
Amethopterin is a chemotherapy drug and immune system inhibitor used to treat cancers of the blood, bone, lung, breast, head, and neck. In addition, it can treat rheumatoid arthritis and psoriasis. |
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T21119 |
Cevimeline
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AF-102B,FKS 508,SNI 2011,HSDB 7286 |
|
|
Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase saliv... |
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T79506 |
Topoisomerase II inhibitor 15
|
|
Topoisomerase
|
|
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1]. |
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T74741 |
TRPV1 activator-1
|
|
|
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TRPV1 Activator-1 (Compound 8), a capsaicin analog featuring a modified neck structure, specifically interacts with the T551 residue [1]. |
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T76918 |
Barecetamab
|
|
|
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Barecetamab (ISU-104), a fully human anti-ErbB3 monoclonal antibody, is utilized in researching recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) [1]. |
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T21964 |
KP372-1
|
|
|
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KP372-1 is an Akt inhibitor which block signalling through the PI3K pathway. KP372-1 inhibit cell proliferation while inducing apoptosis and anoikis in squamous cell carcinoma of the head and neck. |
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T82188 |
HN-1
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|
|
|
HN-1, a 12-mer peptide with specificity for head and neck squamous cell carcinoma (HNSCC), penetrates tumor tissue and facilitates the translocation of agents across cell membranes [1]. |
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T63050 |
JH-XVII-10
|
|
|
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JH-XVII-10 is a selective, orally active and potent inhibitor of DYRK1A (IC50: 3 nM) and DYRK1B (IC50: 5 nM).JH-XVII-10 exhibits antitumor effects in squamous cell carcinoma of the neck (HNSCC) cell lines. |
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T62790 |
JH-XIV-68-3
|
|
|
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JH-XIV-68-3 is a selective inhibitor of the DYRK1A/B macrocycle.JH-XIV-68-3 selectively acts on DYRK1A and its close relative DYRK1B in biochemical and cellular assays.JH-XIV-68-3 has antitumor effects in head and neck s... |
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T73804 |
Botulinum toxin type B
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|
|
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Botulinum toxin type B, an antigen-specific exotoxin produced by the anaerobic bacterium Clostridium botulinum, is utilized in the study of neck dystonia. It inhibits the release of Acetylcholine from the neuromuscular j... |
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T68661 |
Edatrexate
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CGP 30694 |
|
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Edatrexate (CGP 30694), also known as 10-Ethyl-10-deazaaminopterin, is an analog of Methotrexate that demonstrates antitumor activity against Methotrexate-resistant tumors. This antifolate antimetabolite is utilized in r... |
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T35810 |
C24 dihydro Ceramide (d18:0/24:0)
|
Cer(d18:0/24:0) |
|
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C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c... |
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T78096 |
BQ-3020 ammonium
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|
Endothelin Receptor
|
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BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 nM and induces vasoconstriction in rabbit pulmonary arterie... |
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T72776 |
NR2F1 agonist 1
|
|
|
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NR2F1 agonist 1, a specific nuclear receptor NR2F1 activator, initiates dormancy programs in cancer cells by upregulating NR2F1 and its target genes controlling dormancy. This compound promotes neural crest-like features... |
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T63556 |
EGFR-IN-59
|
|
|
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EGFR-IN-59 is an EGFR inhibitor with an IC50 value of 190 nM and an all-time apoptosis inducer. EGFR-IN-59 exhibited cytotoxicity against a non-small lung cancer cell line (A549) and normal lung fibroblasts (WI38) with I... |
