p110δ | TargetMol

カタログ番号	製品名	別名	ターゲット
T16422	P110δ-IN-1	PWT-143	PI3K
	P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).		PI3K
T28416	PIK-108	PIK 108,PIK108	PI3K
	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).		PI3K
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T2297	PIK-294	PIK294	PI3K
	PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).		PI3K
T2083	PI-3065	PI3065	DNA-PK , PI3K , mTOR
	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.		DNA-PK , PI3K , mTOR
T1894	Idelalisib	GS-1101,CAL-101	PI3K , Autophagy
	Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.		PI3K , Autophagy
T8651	CAL-101	(S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib	PI3K
	CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than...		PI3K
T15592	IPI-3063		PI3K
	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).		PI3K
T6938	PF-4989216	PF 4989216	Apoptosis , PI3K
	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.		Apoptosis , PI3K
T1827	Buparlisib	BKM120,NVP-BKM120	Apoptosis , PI3K
	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).		Apoptosis , PI3K
T24873	TGX-115	TGX 115	PI3K
	TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3...		PI3K
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T3348	PIK-293	PIK293	PI3K
	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.		PI3K
T2073	GSK2636771	GSK 2636771,GSK-2636771	PI3K
	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.		PI3K
T1988	Duvelisib	INK1197,IPI-145	PI3K
	Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic a...		PI3K
T7014	Voxtalisib	XL765,SAR245409	DNA-PK , PI3K , mTOR
	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.		DNA-PK , PI3K , mTOR
T16908	Sonolisib	PX-866	PI3K
	Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).		PI3K
T2682	Acalisib	GS-9820,CAL-120	PI3K
	Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.		PI3K
T16365	Buparlisib Hydrochloride	NVP-BKM120 Hydrochloride,BKM120 Hydrochloride	Others
	Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).		Others
T69912	AS2541019
	AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.
T78568	PI3Kδ-IN-15		PI3K
	PI3Kδ-IN-15 (compound 6b) is a potent and selective inhibitor of PI3Kδ, exhibiting an IC50 of 0.5 nM for p110δ and demonstrating over 30-fold selectivity compared to PI3K isoforms γ, β, and α [1].		PI3K
T2661	TGX-221	TGX221	PI3K
	TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.		PI3K
T11610	Idelalisib D5	CAL-101 D5,GS-1101 D5	PI3K
	Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.		PI3K
T81791	MIPS-21335		PI4K
	MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with IC50 values of 0.043, 0.140, 0.386, and 0.742 μM, respective...		PI4K
T1916	Apitolisib	RG 7422,GNE 390,GDC-0980	Apoptosis , PI3K , mTOR
	Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...		Apoptosis , PI3K , mTOR
T3153	Serabelisib	TAK-117,INK1117,MLN1117	PI3K , mTOR
	Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).		PI3K , mTOR
T14191	Alpelisib hydrochloride	BYL-719 hydrochloride	Others
	Alpelisib hydrochloride (BYL-719 hydrochloride) exhibits anticancer properties[1][2]. As a potent, selective PI3Kα inhibitor with high oral bioavailability, it demonstrates IC50 values of 5 nM for p110α, 250 nM for p110γ...		Others
T6143L	PI-103 Hydrochloride
	PI-103 Hydrochloride is a potent dual inhibitor of PI3K and mTOR, demonstrating inhibitory IC50 values of 8 nM for p110α, 88 nM for p110β, 48 nM for p110δ, 150 nM for p110γ, 20 nM for mTORC1, and 83 nM for mTORC2, respec...
T1994	Pictilisib	RG7321,GDC-0941	Apoptosis , PI3K , Autophagy
	Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).		Apoptosis , PI3K , Autophagy
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T2414	Torkinib	PP 242	Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).		Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
T1861	Omipalisib	GSK458,GSK2126458	PI3K , mTOR , Autophagy
	Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.		PI3K , mTOR , Autophagy
T14552	Dactolisib Tosylate	BEZ235 Tosylate,NVP-BEZ 235 Tosylate	PI3K , mTOR
	Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. dactolisib Tosylate inhibi...		PI3K , mTOR
T14944	CGS 15943		PI3K , Adenosine Receptor
	CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.		PI3K , Adenosine Receptor
T11381	Pictilisib dimethanesulfonate	GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
TQ0229	ETP-46321		PI3K
	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).		PI3K
T28439	PP30	PP 30,PP-30
	PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
T10660	CAL-130		PI3K
			PI3K
T10660L	CAL-130 Hydrochloride		PI3K
	CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).		PI3K