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T21195 |
AICAR monophosphate
|
Aica ribonucleotide,AICA riboside,Acadesine 5'-monophosphate,Z-nucleotide |
Others
|
|
AICAR monophosphate (Aica ribonucleotide) is a purine precursor with antineoplastic activity and can be used in studies about type 2 diabetes. |
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T9210 |
CD73-IN-4
|
|
CD73
|
|
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor |
|
T0297 |
Clofarabine
|
Clofarex,Evoltra,Clolar |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
,
Autophagy
|
|
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
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T14864 |
Caracemide
|
NSC-253272 |
Others
,
DNA/RNA Synthesis
,
Antibacterial
|
|
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies. |
|
T3157 |
COH29
|
RNR Inhibitor COH29 |
DNA/RNA Synthesis
|
|
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i... |
|
T8855 |
Polydeoxyribonucleotide(Sodium salt)
|
Polydeoxyribonucleotide from salmon |
Others
|
|
Polydeoxyribonucleotide can improve secretion of various growth factors, promote collagen synthesis, and restore tensile strength of the Achilles tendon in a rat model with Achilles tendon injury. |
|
T0353 |
Osalmid
|
Oxaphenamide,4'-Hydroxysalicylanilide |
HBV
,
DNA/RNA Synthesis
|
|
Osalmid (Oxaphenamide) is a choleretic drug, inhibits ribonucleotide reductase activity by targeting ribonucleotide reductase small subunit M2 (RRM2). |
|
T31163 |
Cytidine 5'-diphosphate disodium
|
CDP sodium salt,Cytidine 5'-diphosphate disodium salt,Cytidine diphosphate sodium salt |
Others
|
|
Cytidine 5'-diphosphate disodium (CDP sodium salt) produces CTP to support DNA and RNA biosynthesis and ribonucleotide reductase to produce dCMP. |
|
T1982 |
3-AP
|
NSC663249,Triapine,PAN-811,OCX191 |
DNA/RNA Synthesis
|
|
3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR). |
|
T7525 |
Didox
|
NSC-324360 |
DNA/RNA Synthesis
|
|
Didox (NSC-324360) is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia. |
|
T8800 |
NSAH
|
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
DNA/RNA Synthesis
|
|
NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively... |
|
T15826 |
Lometrexol
|
LY 264618,DDATHF |
DHFR
|
|
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit ... |
|
T6501 |
Fludarabine Phosphate
|
NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidl... |
|
T29197 |
YZ51
|
|
|
|
YZ51, a novel potent inhibitor of ribonucleotide reductase (RR), inhibits hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. |
|
T14147 |
Pelitrexol
|
AG 2037 |
DHFR
|
|
Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor. |
|
T11921 |
LY 222306
|
|
DHFR
|
|
LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM. |
|
T40862 |
Fludarabine triphosphate
|
F-ara-ATP |
|
|
Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate , inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis. |
|
T68230 |
Amidox
|
|
|
|
Amidox is a ribonucleotide reductase inhibitor. |
|
T24980 |
5-DACTHF
|
543U76,5-Deazacyclotetrahydrofolate |
|
|
5-DACTHF is an inhibitor of glycinamide ribonucleotide transformylase and aminoimidazole ribonucleotide transformylase used as an anti-purine drug. |
|
T10068 |
2'-Azido-2'-deoxyuridine
|
N3dUrd |
Others
|
|
2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity. |
|
T26572 |
AG2034
|
AG-2034,AG 2034 |
|
|
AG2034 is an inhibitor of the glycinamide ribonucleotide formyltransferase (GARFT). |
|
T15813 |
LY309887
|
|
LTR
|
|
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity. |
|
TNU0230 |
2’-Azido-2’-deoxycytidine
|
|
|
|
Nucleoside Derivatives - Azido-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; antiviral agent, DNA synthesis inhibitor; Ribonucleotide reductase inhibitor |
|
TNU0133 |
3’-Azido-3’-deoxycytidine
|
|
|
|
Nucleoside Derivatives –Azido-nucleosides, 3’-Modified nucleosides; Drugs and Inhibitors; Ribonucleotide reductase inhibitor |
|
T11884 |
LSN 3213128
|
|
Others
|
|
LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), wi... |
|
T82950 |
ATIC-IN-1
|
|
|
|
ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This di... |
|
T36300 |
Uridine-5’-monophosphate (sodium salt hydrate)
|
|
|
|
Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during n... |
|
T78814 |
COH1
|
|
DNA/RNA Synthesis
|
|
COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1]. |
|
T15378 |
Gemcitabine elaidate
|
Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
Autophagy
|
|
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel... |
|
T76517 |
Herpes virus inhibitor 2
|
|
|
|
Herpes Virus Inhibitor 2, a compound known for its effectiveness in disrupting the quaternary structure of herpes virus ribonucleotide reductase, functions as a potent inhibitor of viral replication, thereby halting the ... |
|
T76515 |
Herpes virus inhibitor 1
|
|
|
|
Herpes Virus Inhibitor 1 is a compound that inhibits the replication of the herpes virus by disrupting the quaternary structure of its ribonucleotide reductase. This action effectively hinders the virus's ability to repl... |
|
T74088 |
Fludarabine triphosphate trisodium
|
|
|
|
Fludarabine triphosphate (F-ara-ATP) trisodium, the principal metabolite of Fludarabine, acts as a potent, noncompetitive, and specific inhibitor of DNA primase, exhibiting an IC50 value of 2.3 μM and a Ki of 6.1 μM. It ... |
|
T37106 |
2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)
|
|
|
|
2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibi... |
|
T63240 |
Lometrexol disodium
|
|
|
|
Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causin... |
|
T41297 |
Lometrexol hydrate
|
|
|
|
Lometrexol hydrate (DDATHF hydrate) is an antipurine antifolate compound that inhibits glycinamide ribonucleotide formyltransferase (GARFT) activity without inducing detectable DNA strand breaks. It further disrupts de n... |
|
T60401 |
Tezacitabine
|
|
|
|
Tezacitabine is a cytostatic and cytotoxic antimetabolite. Tezacitabine is a nucleoside analogue characterized by a dual mechanism of action. Tezacitabine irreversibly inhibits ribonucleotide reductase and can be incorpo... |
