|
T9303 |
MRTX1133
|
|
Ras
|
|
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors. |
|
T20702 |
Ormetoprim
|
Ro5-9754,Ro 5-9754,Ro-5-9754 |
Antibiotic
|
|
Ormetoprim (Ro 5-9754), an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture. |
|
T0338 |
Minaprine
|
Cantor,Minaprine dihydrochloride,Minaprina,Minaprinum |
MAO
,
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
AChE
,
Monoamine Oxidase
|
|
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states. |
|
T0411 |
Gluconate Calcium
|
Calcium D-gluconate,Gluconic acid hemicalcium salt,Calcium gluconate |
Others
|
|
Gluconate Calcium (Gluconic acid hemicalcium salt) is the calcium salt of gluconic acid, used as a calcium replenisher in hypocalcemic states. |
|
T0285 |
Isoxicam
|
Isoxicamum,Isoxicamo,Maxicam |
COX
|
|
Isoxicam (Isoxicamum) is a non-steroidal anti-inflammatory drug that is not marketed in the United States. |
|
T1175 |
Bromopride
|
Bromoprida,Valopride,Artomey |
Dopamine Receptor
|
|
Bromopride (Valopride) is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in the United States or the United Kingdom. |
|
T3285 |
Eslicarbazepine Acetate
|
Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa |
Beta-Secretase
,
Sodium Channel
|
|
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve... |
|
T10674 |
Potassium Channel Activator 1
|
ZINC34634569 |
Potassium Channel
|
|
Potassium Channel Activator 1 can be used in studies about the treatment of disorders or conditions wherein the dopaminergic system is disrupted such as mood disorders ADHD, schizophrenia, and other psychotic states. |
|
T2585 |
Bedaquiline
|
R207910,TMC207 |
Antibacterial
,
Antibiotic
|
|
Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
|
T16472 |
Pericyazine
|
Propericiazine,RP 8909 |
Dopamine Receptor
|
|
Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych... |
|
T1519L |
Rimonabant
|
SR141716 |
Cannabinoid Receptor
,
Antibacterial
,
Acyltransferase
|
|
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue of effect is a reduction in appetite. Rimonabant... |
|
T0811 |
Amisulpride
|
DAN 2163 |
Dopamine Receptor
,
5-HT Receptor
|
|
Amisulpride (DAN 2163) (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses ... |
|
T1551 |
Tegaserod maleate
|
HTF-919,SDZ-HTF-919 |
5-HT Receptor
|
|
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
|
T1442 |
Pizotifen
|
Pizotyline,BC-105 |
5-HT Receptor
|
|
Pizotifen (Pizotyline) is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties. Pizotifen hydroch... |
|
T0454 |
Florfenicol
|
Nuflor,Aquafen |
Others
|
|
Florfenicol (Aquafen) is a fluorinated synthetic analog of thiamphenicol. In the United States, florfenicol is currently used to treat bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica... |
|
T0454L |
Florfenicol
|
SCH-25298,(-)-Florfenicol |
Antibacterial
,
Antibiotic
|
|
Florfenicol (SCH-25298), a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Haemophilus somnu... |
|
T0910 |
Terpin hydrate
|
Terpin Monohydrate,cis-Terpin hydrate |
Others
|
|
Terpin hydrate, a cis-form hydrate, is derived from sources such as oil of turpentine, oregano, thyme, and eucalyptus. It is used as an insect repellent and expectorant. Terpin hydrate(cis-Terpin hydrate) is commonly use... |
|
T13263 |
COX/5-LO-IN-1
|
Atreleuton analog |
COX
|
|
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. |
|
T27521 |
GX-936
|
GX 936,PF 05196233,PF05196233,GX936,PF-05196233 |
|
|
GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. |
|
T36816 |
S-trityl-L-Cysteine
|
STLC |
Kinesin
|
|
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ... |
|
T34903 |
TO-PRO3 iodide
|
TOPRO3 iodide,TO-PRO3 iodide salt |
|
|
TO-PRO3 iodide is a nucleic acid stain that can stain the nucleus of cells in different states, including living, early apoptotic, and necrotic cells. |
|
T11913 |
LY88074 Methyl ether
|
|
Others
|
|
LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states. |
|
T31819 |
Fluometuron
|
NCI C08695,Ciba 2059,C 2059,NCI-C08695,NCIC08695 |
|
|
Fluometuron is an herbicide. In the United States it was approved for use on cotton and sugarcane crops in 1974, but since 1986 is only approved for use on cotton. |
|
T70854 |
Protokylol hydrochloride
|
|
|
|
Protokylol hydrochloride is the salt form of Protokylol (free base) (Asmetil, Caytine, Palison, Ventaire), a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. It is methylenedioxyphe... |
|
T70613 |
SLP120701 HCl
|
|
|
|
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Interv... |
|
T4497L |
Amifampridine phosphate
|
BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760 |
|
|
Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many c... |
|
T37130 |
MRTX1133 formic
|
|
|
|
MRTX1133 is a highly selective, first-in-class inhibitor of KRAS G12D. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tu... |
|
T70614 |
SLR080811 HCl
|
|
|
|
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h... |
|
T33287 |
Mephentermine Sulfate
|
sulfuric acid,MLS002153976,N,2-dimethyl-1-phenylpropan-2-amine,AC1NWAW7,Mephentermine sodium |
|
|
Mephentermine sulfate is a cardiac stimulant, before as a stimulant in psychiatry, has been used as a treatment for low blood pressure. Mephentermine sulfate is a sympathomimetic agent with specificity for alpha-1 adrene... |
|
T70900 |
VT-ME6
|
|
|
|
VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residu... |
|
T75970 |
Melanin Concentrating Hormone, salmon TFA
|
|
|
|
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide discovered in teleost fish's pituitary gland, involved in controlling food intake, energy balance, sleep states, and cardiovasc... |
|
T69492 |
Ozarelix
|
|
|
|
Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antag... |
|
T22572 |
Angiotensin 1/2 (1-7) amide
|
|
Others
|
|
Angiotensin I/II (1-7) amide is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin I/II amide is an amide derivative of angio... |
|
T70128 |
Olmutinib hydrochloride
|
|
|
|
Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently... |
|
T31194 |
Dalapon
|
Basfapon B,Dowpon M,Dawpon-Rae |
|
|
Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occ... |
|
T35961 |
Prostaglandin Bx
|
|
|
|
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytopr... |
|
T82805 |
Butaprost free acid
|
|
|
|
(R)-Butaprost (free acid) is a prostaglandin E2 (PGE2) analog exhibiting high EP2 receptor subtype selectivity, commonly used to delineate EP receptor expression in human and animal tissues and cells. In 1986, Gardiner i... |
|
T35538 |
HPI-1 (hydrate)
|
HPI-1 hydrate |
|
|
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss o... |
|
T38161 |
STING Agonist C11
|
STING Agonist C11 |
|
|
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory... |
|
T35904 |
O-11
|
|
|
|
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the pr... |
|
T35568 |
BODIPY-aminoacetaldehyde diethyl acetal
|
|
|
|
BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is ... |
