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T22285 |
Carboprost
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15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α |
Prostaglandin Receptor
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Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone. |
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T61702 |
SRI-37240
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SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, ... |
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T31932 |
GJ071 oxalate
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GJ 071,GJ-071,GJ071 |
Others
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GJ071 oxalate is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into na... |
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T9117 |
BSJ-4-116
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CDK
,
Ligand for E3 Ligase
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BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). |
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T6446 |
Clevudine
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L-FMAU,Levovir |
HBV
,
DNA/RNA Synthesis
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Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ... |
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T27108 |
Cymipristone
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ZXH951,ZXH 951,ZXH-951 |
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Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy. |
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T33380 |
MI-389
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MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1). |
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T34426 |
RTC14
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Read-through compound-14,RTC 14,RTC-14,Read-through compound 14 |
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RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. |
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T34425 |
RTC13
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Read-through compound 13,RTC 13,RTC-13 |
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RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. |
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T61306 |
SRI-41315
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SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop... |
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T31933 |
GJ072
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GJ-072,GJ 072 |
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GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent p... |
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T11352 |
Galidesivir triphosphate
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BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870 |
Others
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Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol... |
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T41110 |
EFdA-TP
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EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to a... |
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FL0097 |
Beta-L-D4A
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2'3'-didehydro-2'3'-dideoxyadenosine |
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beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. The biological activity of beta-L-D4A is connected with the termination of the DNA chain synthesis in the 5'-3' direction. |
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T83836 |
3'-O-Methylguanosine-5'-O-triphosphate sodium
|
3'-O-methyl GTP |
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3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates. |
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T15378 |
Gemcitabine elaidate
|
Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
Autophagy
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Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel... |
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T36829 |
9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 |
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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the ... |
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T35802 |
ML-345
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Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin a... |
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T60401 |
Tezacitabine
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Tezacitabine is a cytostatic and cytotoxic antimetabolite. Tezacitabine is a nucleoside analogue characterized by a dual mechanism of action. Tezacitabine irreversibly inhibits ribonucleotide reductase and can be incorpo... |
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T38297 |
Ribavirin-13C5
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Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to a... |
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T37821 |
AP 14145 hydrochloride
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KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rat... |
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T36999 |
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
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Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog ... |
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T37585 |
Ensartinib
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Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or ... |
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T36881 |
NHC-diphosphate triammonium
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NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral poly... |
