|
T10900 |
CUDA
|
|
PPAR
,
Epoxide Hydrolase
|
|
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... |
|
T28360 |
PF-00489791
|
PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817 |
PDE
|
|
PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy. |
|
T21957 |
Guanabenz hydrochloride
|
NE56490 |
Adrenergic Receptor
|
|
Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects. |
|
T26923 |
Bunazosin Hydrochloride
|
E 1015,E643,E-1015,E-643,E 643 |
Adrenergic Receptor
|
|
Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug. |
|
T24932 |
Vatanidipine
|
AE-0047,AE 0047,AE0047 |
Calcium Channel
|
|
Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi... |
|
T0028 |
Gamibetal
|
3-Hydroxy-GABA,4-Amino-3-hydroxybutyric Acid |
HIV Protease
|
|
Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Ac... |
|
TP1918L |
Lys-[Des-Arg9]Bradykinin,TFA
|
Lys-[Des-Arg9]Bradykinin,TFA 71800-36-7(fb-tfa) |
Bradykinin Receptor
|
|
Lys-[Des-Arg9]Bradykinin,TFA is Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripher... |
|
TP1917L1 |
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
|
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) |
Bradykinin Receptor
|
|
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cl... |
|
T22398 |
Phenidone
|
1-phenyl-3-pyrazolidinone |
Lipoxygenase
,
COX
|
|
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg... |
|
T1012 |
Acebutolol hydrochloride
|
Acebutolol HCl |
Adrenergic Receptor
|
|
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydro... |
|
TP1918L1 |
Lys-[Des-Arg9]Bradykinin acetate
|
Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base) |
Bradykinin Receptor
|
|
Lys-[Des-Arg9]Bradykinin acetate is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces p... |
|
T1050 |
Prazosin hydrochloride
|
Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress |
Potassium Channel
,
MRP
,
Adrenergic Receptor
,
ABC
,
Autophagy
|
|
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ... |
|
T0782 |
Benzthiazide
|
Aquatag,Lemazide,Dihydrex |
Carbonic Anhydrase
|
|
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ... |
|
T68095 |
Losulazine
|
|
Dopamine Receptor
,
Norepinephrine
|
|
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-b... |
|
T34414 |
RS 61565
|
RS-61565,RS61565 |
|
|
RS 61565 is a hypotensive agent. |
|
T34294 |
Reserpiline
|
Elliptamine |
|
|
Reserpiline is a hypotensive extract of Rauwolfia vomitoria. |
|
T26586 |
AL-37350A
|
|
|
|
AL-37350A is a 5-HT2 receptor-selective agonist with ocular hypotensive activity. |
|
T26426 |
A 62198
|
A62198,A-62198 |
|
|
A 62198 is a potent and selective renin inhibitor with potential as a hypotensive agent. |
|
T32458 |
L 653328
|
L 653,328,L653328,L653,328,L-653,328,L-653328 |
|
|
L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity. |
|
T30452 |
Bimatoprost isopropyl ester
|
17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester |
|
|
Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug. |
|
T27754 |
KUL-7211
|
KUL7211,KUL 7211 |
|
|
KUL-7211 is an β2 and β3 adrenergic receptor agonist. KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect. |
|
T21274 |
Amiquinsin
|
|
|
|
Amiquinsin is a drug with hypotensive effect. |
|
T68774 |
Deterenol Free Base
|
|
|
|
Deterenol Free Base is a beta-adrenoceptor agonist. It is an effective nonmydriatic and nonmiotic hypotensive agent, which can be used in antiglaucoma treatment. |
|
T39246 |
Brain Natriuretic Peptide-45, mouse
|
Brain Natriuretic Peptide-45, mouse,BNP-45, mouse |
|
|
Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties. |
|
TP1257 |
Adrenomedullin (AM) (22-52), human
|
22-52-Adrenomedullin (human) |
|
|
Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin. |
|
T62476 |
Trimazosin
|
|
|
|
Trimazosin is an orally active quinazoline derivative, structurally related to prazosin. trimazosin has hypotensive activity by selectively blocking alpha1-adrenoceptors. |
|
T10544 |
Bimatoprost D5
|
AGN 192024 D5 |
Others
|
|
Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension. |
|
T26417 |
A 39355
|
A39355,A-39355 |
|
|
A 39355 may specifically overcome multidrug resistance without the serious hypotensive effects associated with calcium antagonists. |
|
T13142 |
Theodrenaline
|
(±)-Theodrenaline |
Others
|
|
Theodrenaline is a cardiac stimulant, also acts as an agent of anti-hypotensive together with cafedrine. |
|
T17113 |
Tolonidine
|
|
Others
|
|
Tolonidine is orally active and has been shown to possess hypotensive. Tolonidine is a derivative of imidazoline. |
|
T37813 |
Fluprostenol methyl ester
|
|
|
|
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY... |
|
T75084 |
Foslevcromakalim
|
|
|
|
Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2]. |
|
T16711 |
Flesinoxan
|
|
5-HT Receptor
|
|
|
|
TP1917 |
Sar-[D-Phe8]-des-Arg9-Bradykinin
|
|
|
|
Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic ac... |
|
T29725 |
AGN-191129
|
AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T |
|
|
AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypote... |
|
T38017 |
Nω-Propyl-L-arginine hydrochloride
|
|
|
|
Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
Kakoki et al (2001) The influence of nitric oxide synthase 1 o... |
|
T61075 |
Piperilate
|
|
|
|
Piperilate, also known as Pipethanate, is a hetrazepine derivative PAF antagonist and anticholinergic mixture, commonly utilized in bronchial asthma research. This compound exhibits hypotensive properties and has been fo... |
|
T9819 |
Bunazosin
|
|
|
|
Bunazosin is a potent and selective α1-adrenoceptor antagonist that can be used for antihypertensive and ocular hypotensive research [1]. |
|
T68707 |
DJ 7141
|
|
|
|
DJ 7141 is a unique alpha-2 agonist which shows high affinity to peripheral alpha-2 adrenoceptors but only a mild hypotensive activity. |
|
T25568 |
Ketanserinol
|
Reduced ketanserin |
|
|
Ketanserinol is the metabolite of ketanserin. Ketanserin is a hypotensive drug with 5-HT2 receptor antagonism, used to reverse pulmonary hypertension caused by protamine. |
|
TP1885 |
[(pF)Phe4]Nociceptin(1-13)NH2
|
|
|
|
Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronocicep... |
|
T82823 |
Brain Natriuretic Peptide-45, rat TFA
|
BNP-45, rat TFA |
|
|
Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is an isoform of rat brain natriuretic peptide extracted from rat heart, exhibiting significant hypotensive and natriuretic effects [1]. |
|
TP1207 |
Brain Natriuretic Peptide-45, rat
|
BNP-45 (rat),Brain natriuretic peptide-45 rat |
|
|
BNP-45 (rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency. |
|
T37627 |
Latanoprost ethyl amide
|
|
|
|
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-e... |
|
TP1206 |
BNP-45 (rat) (TFA) (123337-89-3 free base)
|
BNP-45 (rat) (TFA),Brain natriuretic peptide-45 rat TFA |
|
|
BNP-45 (rat) TFA is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency. |
|
T62744 |
LpxC-IN-9
|
|
|
|
LpxC-IN-9 (compound 19) is a potent inhibitor of LpxC and exhibits antibacterial and hypotensive activity. |
|
T37213 |
5-trans Latanoprost
|
|
|
|
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been chan... |
|
T33287 |
Mephentermine Sulfate
|
sulfuric acid,MLS002153976,N,2-dimethyl-1-phenylpropan-2-amine,AC1NWAW7,Mephentermine sodium |
|
|
Mephentermine sulfate is a cardiac stimulant, before as a stimulant in psychiatry, has been used as a treatment for low blood pressure. Mephentermine sulfate is a sympathomimetic agent with specificity for alpha-1 adrene... |
|
TP1901 |
Hemopressin(rat)
|
Hemopressin (rat) |
|
|
Hemopressin(rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. |
|
TP1918 |
Lys-[Des-Arg9]Bradykinin
|
|
|
|
Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. ... |
