Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 98,000 | |||
50 mg | 在庫あり | ¥ 149,000 | |||
100 mg | 在庫あり | ¥ 212,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 39,000 |
説明 | FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively). |
ターゲット&IC50 | Prostaglandin synthetase:3.1 μM , 5-LOX (RBL-1 cytosolic):3.5 μM |
In vivo | FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation. |
動物実験 | Animal Model:Female LACA mice (20-30 g) injected with immune complex. Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg. Administration:Intraperitoneal injection. |
分子量 | 265.31 |
分子式 | C16H15N3O |
CAS No. | 103141-09-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (942.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FPL 62064 103141-09-9 Immunology/Inflammation Metabolism Neuroscience COX Lipoxygenase Cyclooxygenase LOX 5-lipoxygenase inhibit Prostaglandin 5-LOX FPL62064 Inhibitor synthetase anti-inflammatory COX-2 FPL-62064 inhibitor